The following is a summary of the “Conradi-Hünerman-Happle Syndrome and Obsessive–Compulsive Disorder: a clinical case report,” published in the February 2023 issue of Psychiatry by Jesus, et al.

Intrusive, uncontrollable, and repetitive thoughts (i.e., obsessions) and/or ritualistic behaviors characterize Obsessive-Compulsive Disorder (OCD), a common and chronic mental condition with high morbidity (i.e., compulsions). Chondrodysplasia punctata is rare bone dysplasia characterized by punctate epiphyseal calcifications of complicated origin and pathophysiology that have yet to be fully elucidated; Conradi-Hünerman-Happle Syndrome (CHHS) is an X-linked dominant variation of this condition.

It turns out that there is a gap in the literature when it comes to the existence of the entities together, with no clinical reports describing their cohabitation. As a result of the severe functional impairment brought on by the increased frequency with which she washed her hands during the Covid-19 outbreak, a 12-year-old girl diagnosed with CHHS seeks psychiatric consultation. 

Antipsychotic and Selective Serotonin Reuptake Inhibitor (SSRI) medications were used to treat obsessive-compulsive disorder, with positive, albeit limited, results. This paper will give a case study of a patient with Conradi-Hünerman-Happle syndrome and obsessive-compulsive disorder. There is a lack of clinical accounts of CHHS and OCD in the literature. By describing this case, the scientists hope to shed light on a very unusual instance and possibly a connection between the etiology and pathophysiology of the 2 diseases.

Source: bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-023-04579-1