The following is a summary of “Association of Neutrophil Mediators With Dengue Disease Severity and Cardiac Impairment in Adults,” published in the December 2022 issue of Infectious Diseases by Chia, et al.


Hypotension in severe dengue (SD) is exacerbated by cardiac dysfunction. There wasn’t enough research, though, that looked at the pathogenic variables that contributed to the cardiac dysfunction linked to dengue. For a study, researchers sought to determine the impact of neutrophil mediators on cardiac dysfunction in clinical dengue.

Adult dengue patients and controls were enrolled prospectively. A bioimpedance device was used to assess cardiac parameters. Myeloperoxidase (MPO) and citrullinated histone H3 were detected as neutrophil mediators.

Thirty control subjects and 107 dengue cases were recruited. Dengue patients were categorized in accordance with 2009 World Health Organization recommendations (44 with dengue fever [DF], 51 with DF with warning signs, and 12 with SD). Stroke index (P< .001), cardiac index (P =.03), and Granov-Goor index (P< .001) were all considerably lower in dengue patients throughout the critical period than in controls. In the crucial period, MPO was substantially higher in dengue patients than in controls (P< .001) and in patients with SD than in patients with DF. Additionally, during the crucial period and longitudinally, MPO had an adverse relationship with the Granov-Goor, cardiac, and stroke indices.

When compared to patients with DF and controls, SD patients’ cardiac function declined and their MPO levels rose throughout the crucial phase. The cardiac damage linked to dengue may be mediated by MPO.

Reference: academic.oup.com/jid/article-abstract/226/11/1974/6706606?redirectedFrom=fulltext