The following is a summary of “Elevated concentration of beta2-microglobulin among patients with carpal tunnel syndrome in the course of primary Sjogren syndrome – a prospective observational study on 50 patients,” published in the July 2024 issue of Rheumatology by Kościńska-Shukla et al.

Sjogren’s syndrome (SS) involves chronic autoimmune inflammation with lymphocytic infiltration in exocrine glands, potentially correlating with increased occurrence of c (CTS) compared to the general population.

Researchers conducted a prospective study exploring correlations between CTS and laboratory and clinical parameters in patients with SS.

They included 50 patients diagnosed with primary SS (pSS), who underwent clinical assessment by a rheumatologist, and electrophysiological studies. Laboratory test data were gathered. A control group of 50 individuals matched for sex and age with osteoarthritis (OA) was also included.

The result showed 50 patients in the group, only 27 (54%) were diagnosed with CTS. In the control group of 50 individuals, the prevalence of CTS was 8%. Comparing patients with pSS with and without CTS, joint involvement rates were similar [15 vs. 13 (P=0.945)]. However, significant differences were observed in sleep disorders [18 vs. 9 (P=0.012)] and paresthesia [23 vs. 13 (P=0.024)]. Elevated beta2-microglobulin (B2MG) levels were significantly more common in the CTS group [23 vs. 13 (P=0.024)]. Other factors studied, suggested in the literature as significant in pSS-related neuropathy, did not show statistically significant differences between the groups.

Investigators concluded that the higher prevalence of CTS among patients with pSS indicated a need for a new approach to understanding the pathogenesis, suggesting CTS may be linked more to overall disease activity rather than joint involvement alone.

Source: link.springer.com/article/10.1007/s00296-024-05640-2