The following is a summary of the “More gain, less pain: How resistance training affects immune system functioning in multiple sclerosis patients: A review,” published in the January 2023 issue of Multiple Sclerosis and Related Disorders by Amin, et al.

Similarly to the baffling and variable therapy responses seen in MS patients, the origin of MS is a mystery. While there is justifiable excitement about the potential of epigenetics research to shed light on the mystery of abnormal reactions to treatment, there is no denying that, in the meanwhile, non-pharmaceutical approaches to improving management tactics are necessary. 

They focus on resistance training (RT) because of its promise as a disease-modifying tool and because it is an exercise-based interventional method that does not rely on pharmaceuticals. Multiple sclerosis (MS) patients have reported improvements in their QoL and functional capacity after receiving RT, and one possible explanation for these improvements is a change in their immune system. Multiple sclerosis (MS) pathologies are related to several important immune system players, and RT has been shown to influence these players. 

This brief review’s overarching goal is to suggest that using RT as an interventional exercise modality may be an effective strategy for managing such a complex and debilitating disease by establishing a possible but crucial link between RT, changes in the expression profile of the immune system, and eventual improvements in the well-being and QoL of MS patients.