The study analyzed cholesterol-lipoprotein pictures of men aged 18-44, 45-59, and over 60 who followed different intensity of motor activity. For the objective, the AU680 analyzer enzymatic method was applied to determine the blood serum concentration levels of total cholesterol (CHC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglycerides (TG) as well as to assess the atherogenicity of the lipid profile using the calculating coefficient. The imbalance in lipid metabolism was observed through all the studied parameters and differed between examined groups immensely: it existed in 14% of young men, 20% of middle-aged subjects and 1% of the elderly of those from the intense activity group vs. 26, 40 and 21% of those from the sedentary lifestyle group. Decreased physical activity results in elevated concentrations of cholesterol and LDL at the age of 45-59, while those who perform exercises develop these symptoms after 60 years of age. The lipid profile of subjects with sedentary lifestyle appears to be more atherogenic, with higher average blood concentrations of cholesterol, LDL and TG, and lower HDL. In general, among 45-59 aged volunteers of the Magadan survey who exhibit various activity levels, there is a significant percentage of individuals with IIa phenotype of dyslipidemia, which is considered atherogenic and aggravating the risk of atherosclerosis. This age should be referred to a risk group. The effectiveness of prevention of lipid metabolism disorders with increasing physical activity appears to be highest in older age.