AEGIS-II: Negative Primary Endpoint but Infusions Might Benefit Subgroups of Patients
Infusions with human apolipoprotein A-1 failed to significantly reduce major adverse cardiovascular events in patients with myocardial infarction.
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Author: Teresa Sellinger
PCSKP Inhibitor Achieves LDL-C Goals for Patients With High Risk for Cardiovascular Disease
Lerodalcibep reduced low-density lipoprotein-cholesterol (LDL-C) of 50–60% at week 52 of the phase 3 LIBerate-HR trial.
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Safety of TAVI Noninferior to SAVR for Patients With Lower Surgical Risk
DEDICATE trial shows transcatheter aortic valve implantation in patients with low-to-intermediate risk is not inferior to surgical aortic valve replacement.
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KARDIA-2: Add-On Zilebesiran Effectively Lowers Blood Pressure
A single subcutaneous dose of zilebesiran was associated with a reduction in mean ambulatory and office systolic blood pressure.
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Protein Drinks and Exercise Intervention Improve Physical Performance in Frail Patients Undergoing TAVR
Combining a protein supplement with exercise improved strength, mobility, and balance after transcatheter aortic valve replacement.
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New Initiatives for Pain Management Discrepancies in COPD Guidelines
Optimizing pain management strategies can help physicians better support patients with COPD in their journey towards improved health and well-being.
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Nonpharmacologic Interventions Help Address Pain Management in Patients With COPD
In Part 2, Dr. Brockway reviews non-pharmacological interventions, such as physical therapy, for pain management in COPD.
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PROMs as Important as Disease Activity Indexes for Assessing PsA
New findings show that PROMs were strongly associated with several PsA activity indexes, and are as important as disease activity indexes for assessing PsA.
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Q&A: The Need for Periodic Assessment of Antiseizure Drug Load in Epilepsy
The impact of overall medication burden on QOL for patients with epilepsy underscores the need to periodically assess antiseizure drug load for these patients.
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Women With Chronic Coronary Disease Less Likely to Achieve Risk-Reduction Goals Than Men
“Our results highlight a need to be extra attentive to risk-factor modification among women,” says Harmony Reynolds, MD.
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Spinal Cord Atrophy and Inflammation Help Predict MS Progression
In MS, progression independent of relapse activity is associated with neurodegenerative processes in the spinal cord and the presence of chronic active lesions.
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Liability Issues in Limited Examinations
Even though physicians who conduct limited examinations may only be brought in for their expertise, they retain liability for malpractice or personal injury.
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Cardiac Involvement in Rosai-Dorfman Disease May Be More Common Than Previously Thought
While cardiac manifestations in Rosai-Dorfman Disease are largely uncommon, they do occur and can further complicate the diagnosis of this rare blood disorder.
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Gathering Data on Healthcare Inequities to Enact Change
Health inequities pervade the healthcare system, making it crucial for physicians to reevaluate what data is being collected and who is collecting the data.
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RELIEVE-HF: Interatrial Shunt May Prove Advantageous for Patients With HFrEF
RELIEVE-HF trial showed an interatrial shunt device implant in patients with LVEF less than or equal to 40% led to a CV event rate of 49% per year.
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Fewer Than 20% of High-Risk Patients Screened for Latent TB
Regularly asking about risk factors for tuberculosis, such as birthplace and travel history, may improve testing of those at high risk for latent infection.
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BE ACTIVE Study Shows Small Incentives Increase Daily Steps
Earning points and small amounts of money encouraged patients with high risk for cardiovascular disease to increase their daily walking by about 10%.
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Q&A: Prompt Diagnosis of Age-Related Macular Degeneration
With a projected increase in cases of age-related macular degeneration, prompt diagnosis and treatment are needed to mitigate vision loss and societal burdens.
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Olezarsen Effectively Lowers Triglycerides
Olezarsen lowered triglycerides by about 50% at month 6 compared with placebo in the BRIDGE-TIMI73a trial and reduced other markers of atherogenic risk.
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“Inclisiran First” Strategy Effectively Reduces LDL Concentrations in Patients With ASCVD
Earlier introduction of inclisiran significantly reduced LDL concentrations without affecting statin compliance in ASCVD in phase 3b VICTORIAN-INITIATE trial.
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