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Menopause

Understanding the barriers to, and facilitators of, ovarian toxicity assessment in breast cancer clinical trials.

May 23, 2022

Detailed toxicity data are routinely collected in breast cancer (BC) clinical trials. However, ovarian toxicity is infrequently assessed, despite the adverse impacts on fertility and long-term health ...

Sex Differences in the Immune System in Relation to Hypertension and Vascular Disease.

May 23, 2022

Hypertension is the leading risk factor for cardiovascular disease and mortality worldwide. Despite intensive research into the mechanisms underlying the development of hypertension, it remains diffic...

Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality.

May 16, 2022

Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such rela...

Menopause: a cardiometabolic transition.

May 09, 2022

Menopause is often a turning point for women's health worldwide. Increasing knowledge from experimental data and clinical studies indicates that cardiometabolic changes can manifest at the menopausal ...

Male mating choices: The drive behind menopause?

May 09, 2022

When we examine the life history of humans against our closest primate relatives, the other great apes, there is notably a greater longevity in humans which includes a distinctive postmenopausal life ...

Is early menopause a potential criterion for cardiovascular risk screening to detect high risk in a multi-ethnic population? The Helius study.

May 02, 2022

Women at risk of cardiovascular disease (CVD) may be missed with current eligibility criteria for CVD risk screening, particularly those from ethnic minority groups, among whom high risk is prevalent ...

Are serum estrogen concentrations associated with menopausal symptom bother among postmenopausal women? Baseline results from two MsFLASH clinical trials.

May 02, 2022

To evaluate whether single measurements of serum estradiol (E), estrone (E) and sex hormone-binding globulin (SHBG) concentration distinguishes between women with and without menopausal symptom bother...

Challenges to Longitudinal Characterization of Lower Urinary Tract Dysfunction in Multiple Sclerosis.

Apr 25, 2022

Neurogenic lower urinary tract dysfunction (LUTD) results in lower urinary tract symptoms (LUTS) that impact quality of life in people with multiple sclerosis (PwMS). The risk factors and the contribu...

Female Pelvic Conditions: Genitourinary Syndrome of Menopause.

Apr 18, 2022

(GSM) is a term that describes the genital, urinary, and sexual changes that occur in women because of a lack of estrogen. This most commonly is because of menopause, but can be because of a hypoestr...

The Impact of Local Estrogen on the Urogenital Microbiome in Genitourinary Syndrome of Menopause: A Randomized-Controlled Trial.

Apr 18, 2022

The postmenopausal urinary bladder microbiome is not well defined.The aims of this study were to characterize the effect of vaginal estrogen on the vaginal and urinary bladder microbiome in postmenopa...

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization.

Apr 11, 2022

Studies suggest that adiposity in childhood may reduce the risk of breast cancer in later life. The biological mechanism underlying this effect is unclear but is likely to be independent of body size ...

A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial.

Apr 11, 2022

Most women develop MS before menopause. Menopausal hot flashes can worsen MS symptoms, and could be relieved with hormone therapy. Our objective was to evaluate feasibility, tolerability and symptom r...

Hepatic Adropin is Regulated by Estrogen and Contributes to Adverse Metabolic Phenotypes in Ovariectomized Mice.

Apr 04, 2022

Menopause is associated with visceral adiposity, hepatic steatosis and increased risk for cardiovascular disease. As estrogen replacement therapy is not suitable for all postmenopausal women, a need f...

Treat more than heat-New therapeutic implications of Cimicifuga racemosa through AMPK-dependent metabolic effects.

Mar 28, 2022

Cimicifuga racemosa extracts (CRE) have obtained a "well-established use status" in the treatment of postmenopausal (i.e., climacteric) complaints, which predominantly include vasomotor symptoms such ...

Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox.

Mar 21, 2022

Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular ca...

Delivering specialised care to people ageing with HIV in the UK: experience and evolution of services from 2009 to 2019.

Mar 21, 2022

The introduction of antiretrovirals has resulted in a demographic shift with an increasing proportion of people living with HIV older than 50 years and a change in the spectrum of diseases affecting t...

Genetic Diagnostics in Routine Osteological Assessment of Adult Low Bone Mass Disorders.

Mar 14, 2022

Many different inherited and acquired conditions can result in premature bone fragility / low bone mass disorders (LBMD).We aimed at elucidating the impact of genetic testing on differential diagnosis...

Acupuncture in the real world: evaluating a 15-year NADA auricular acupuncture service for breast cancer survivors experiencing hot flushes and night sweats as a consequence of adjuvant hormonal therapies.

Mar 07, 2022

While clinical trials provide valuable data about efficacy of interventions, findings often do not translate into clinical settings. We report real world clinical outcomes of a 15-year service offerin...

Low bone mass and vitamin D in Brazilian people living with HIV under antiretroviral therapy.

Mar 07, 2022

We performed a cross-sectional study in 212 PLHIV under antiretroviral therapy. Bone mass was compromised in 36.5% of relatively young sample and associated with hypogonadism, older age, higher PTH le...

The mediating effect of pleasure and menopausal symptoms on sexual activity among young breast cancer survivors.

Feb 28, 2022

Young breast cancer survivors often go through a rapid change in menopause status due to cancer treatment and suffer from abrupt symptoms. This transition compels them to deal with unique medical and ...