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Neurology

Prenatal Valproate Exposure Tied to Psychiatric Disorders in Late Childhood

May 24, 2023

WEDNESDAY, May 24, 2023 (HealthDay News) -- Prenatal exposure to the antiepileptic medication valproate is associated with an increased risk for later psychiatric disorders among children of mothers w...

Catching Extra Sleep on Weekends Tied to Lower Risk for Hyperuricemia

May 24, 2023

WEDNESDAY, May 24, 2023 (HealthDay News) -- Weekend catch-up sleep among postmenopausal women is associated with a decreased prevalence of hyperuricemia, according to a study published online May 16 i...

U.S. Surgeon General Warns That Social Media Can Harm Teens' Mental Health

May 24, 2023

TUESDAY, May 23, 2023 (HealthDay News) -- Social media presents a "profound risk" to young brains, U.S. Surgeon General Vivek Murthy, M.D., warned on Tuesday.In the new report -- Surgeon General's Adv...

Economic Burden of Health Inequities Very High in the United States

May 24, 2023

TUESDAY, May 23, 2023 (HealthDay News) -- The economic burden of health disparities in the United States is very high, according to a study published in the May 16 issue of the Journal of the American...

Association Between PTE and Long-Term Functional Outcomes in Severe TBI Individuals

May 22, 2023

The following is a summary of "Association of Posttraumatic Epilepsy With Long-term Functional Outcomes in Individuals With Severe Traumatic Brain Injury," published in the May 2023 issue of Neurology...

Treatment of obstructive sleep apnea with a simple CPAP device.

May 22, 2023

CPAP is the "gold standard" treatment for obstructive sleep apnea (OSA). Current CPAP models have developed additional functions including automatic CPAP and pressure relief. However, CPAP adherence h...

A new neurodevelopmental disorder linked to heterozygous variants in UNC79.

May 22, 2023

The "NALCN channelosome", is an ion channel complex consisting of multiple proteins including NALCN, UNC79, UNC80, and FAM155A. NALCN and UNC80 variants are described in a small number of individuals ...

Differential effects of dopamine receptor agonists ropinirole and quinpirole on locomotor and anxiolytic behaviors in larval zebrafish (Danio rerio): A role for the GABAergic and glutamate system?

May 22, 2023

Zebrafish are frequently used as a vertebrate model to elucidate toxicological and pharmacological mechanisms of action in the central nervous system. Pharmacological studies demonstrate that dopamine...

JMJD8 regulates neuropathic pain by affecting spinal cord astrocyte differentiation.

May 22, 2023

The demethylase JmjC structural domain-containing protein 8 (JMJD8) has been demonstrated to be involved in cellular inflammatory responses. Neuropathic pain (NP) is a chronic pain, and it is unclear ...

Spatial access to buprenorphine-waivered prescribers in the HEALing communities study: Enhanced 2-step floating catchment area analyses in Massachusetts, Ohio, and Kentucky.

May 22, 2023

The opioid overdose epidemic continues to impact a large swath of the population in the US. Medications for opioid use disorders (MOUD) are an effective resource to combat the epidemic; however, there...

Pharmacognostic profiles, evaluation of analgesic, anti-inflammatory and anticonvulsant activities of Newbouldia laevis (P. Beauv.) Seem. ex Bureau leaf and root extracts in Wistar rats.

May 22, 2023

Newbouldia laevis is a popular medicinal plant whose leaves and roots are used in Nigeria as ethnomedicinal prescriptions for pain, inflammation, convulsion, and epilepsy. These claims have not been s...

Natalizumab extended-interval dosing in a real-life setting.

May 22, 2023

Natalizumab is a high-efficacy therapy for recurrent multiple sclerosis (RMS) with a four-week administration interval. Controlled trials have shown that extending this interval to six weeks led to be...

The importance of the patient's perspective in decision-making in multiple sclerosis: Results of the OwnMS patient perspectives study.

May 22, 2023

Research is needed to identify the unmet disease education and communication needs of people with multiple sclerosis (PwMS) to support informed decision-making, enable self-management and maintain ind...

Sleep of migraine patients is ameliorated by ketogenic diet, independently of pain control.

May 22, 2023

Migraine patients are frequently affected by sleep complaints. The ketogenic diet (KD) is an option for the treatment of migraine. Our aim was: 1) to assess the effects of KD on sleep complaints in pa...

Safety and efficacy of rimegepant orally disintegrating tablet for the acute treatment of migraine in China and South Korea: a phase 3, double-blind, randomised, placebo-controlled trial.

May 22, 2023

No acute treatments targeting calcitonin gene-related peptide (CGRP) have been approved for use in China or South Korea. We aimed to compare the efficacy and safety of rimegepant-an orally administere...

Brain morphometric changes in fibromyalgia and the impact of psychometric and clinical factors: a volumetric and diffusion-tensor imaging study.

May 22, 2023

Previous studies have repeatedly found distinct brain morphometric changes in patients with fibromyalgia (FM), mainly affecting gray and white matter abnormalities in areas related to sensory and affe...

Moment-to-moment relationships between pain, fatigue, and distress as a function of GI symptoms in fibromyalgia.

May 22, 2023

There is emerging evidence that people with both fibromyalgia and functional gastrointestinal (GI) disorders report more severe psychological symptoms than people with only fibromyalgia or a functiona...

Long-term safety of medical cannabis in Parkinson's disease: A retrospective case-control study.

May 22, 2023

Whole-plant medical cannabis (MC) products are widely used for controlling symptoms associated with Parkinson's disease (PD). Despite its widespread use, few studies have investigated the long-term im...

Impact of therapeutic and low volume plasma exchange on clinical laboratory parameters in patients treated for Alzheimer's disease from the AMBAR study.

May 22, 2023

Little is known about the impact of plasma exchange (PE) on clinical laboratory parameters in Alzheimer's disease (AD) patients.AD patients in the AMBAR trial (N = 322) received weekly therapeutic...

Identifying the most important research, policy and practice questions for substance use, problematic alcohol use and behavioural addictions in autism (SABA-A): A priority setting partnership.

May 22, 2023

Autistic people are more likely to report problematic alcohol and other substance use when compared to the general population. Evidence suggests that up to one in three autistic adults may have an alc...