Alzheimer’s disease (AD) is a complex neurodegenerative disease with no availability of disease-modifying therapeutics. The complex etiology and recent failures in clinical trials indicate the need for multitargeted...
Alzheimer’s disease (AD) is the most common neurodegenerative disease. Deposition of amyloid β plaques (Aβ) and neurofibrillary tangles (NFTs) is the key pathological hallmark of AD. Accumulating evidence suggest that...
Alzheimer’s disease (AD) is a destructive neurodegenerative disease that currently has no effective treatment option available. Ginkgolide B (GB) is a terpene lactone derivative of Ginkgo biloba that possesses...
Dysregulation of neuroinflammation is a key pathological factor in the progressive neuronal damage of neurodegenerative diseases. An in-house natural products library of 1407 compounds were screened against neuroinflammation in...
This study aimed to identify potential anti-Alzheimer’s disease (AD) targets and action mechanisms of (GF) through a network pharmacology approach. Eighty-four potential targets of 10 active anti-AD ingredients of GF were...
Known as one of the most sophisticated systems of the human body, the nervous system consists of neural cells and controls all parts of the body. It is closely related to the immune system. The effects of inflammation and immune...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to memory loss and is often accompanied by increased anxiety. Although AD is a heterogeneous disease, dysregulation of inflammatory pathways...
In 2020 the coronavirus disease 19 (COVID-19) pandemic imposed a total and sudden lockdown. We aimed to investigate the consequences of the first COVID-19 lockdown (mid-March – mid-April 2020) on motor and non-motor...
Although beta-amyloid (Aβ) positivity has shown to be associated with higher risk of progression to Alzheimer’s disease (AD) in mild cognitive impairment (MCI), information on the time to conversion to manifest dementia...
Rhythmic Auditory Stimulation (RAS) involves synchronizing footsteps to music or a metronome to improve gait speed and stability in patients with neurological disorders, such as Parkinson’s disease. However, responses to...
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. This study aims to screen specific modules and key genes related to PD.Gene expression profile data GSE6613 and GSE22491 were downloaded from...
Alzheimer’s disease (AD) is the most common neurodegenerative disorder where the accumulation of amyloid plaques and the formation of tau tangles are the prominent pathological hallmarks. Increasing preclinical and...
