Dopamine (DA) in the striatum is essential to influence motor behavior and may lead to movement impairment in Parkinson’s disease (PD). The present study examined the different functions of the DA D1 receptor (D1R) and DA...
Novel N-Benzylpyrrolidine hybrids were designed, synthesized, and tested against multiple in-vitro and in-vivo parameters. Among all the synthesized molecules, 8f and 12f showed extensive inhibition against beta-secretase-1...
This study aims to reconsider diagnostic approaches to dementia where pharmacological approaches are not available to reverse the pathological changes caused by dementia.A questionnaire survey was conducted with 524 physicians...
To investigate the effect of aerobic exercise (AE) on functional capacity and quality of life in individuals with Parkinson’s disease (PD) in the mild to moderate stages.Medline, Embase, Web of Science, The Cochrane...
Alzheimer’s disease is a progressive neurodegenerative disorder with cognitive and memory impairment. Benincasa hispida is being used in the treatment of various neurological diseases in Ayurveda system of medicine. The...
How people with Parkinson’s disease habituate their postural response to unpredictable translation perturbation is not totally understood. We compared the capacity to change the postural responses after unexpected external...
The electrode-tissue interface surrounding a deep brain stimulation (DBS) lead is known to be highly dynamic following implantation, which may have implications on the interpretation of intraoperatively recorded local field...
Adaptive deep-brain stimulation (aDBS) based on subthalamic nucleus (STN) electrophysiology has recently been proposed to improve clinical outcomes of DBS for Parkinson’s disease (PD) patients. Many current models for aDBS...
Alzheimer’s disease (AD) is the most common form of dementia, particularly in older adults, with clinical manifestations of progressive cognitive decline and functional impairment. The prevalence of AD and related dementia...
Parkinson’s disease (PD) is the most common degenerative cause of movement disorder, and autonomic dysfunction has been recognized in this disorder. PD patients’ lower urinary tract (LUT) function is not established....
Alzheimer’s disease (AD) is a neurodegenerative disorder, associated with the aggregation of amyloid beta (Aβ) peptides and formation of plaques. The impact of airborne particulate matter (PM) and ultrafine particles...
It is unclear whether women have higher brain tau pathology. The objective of this study was to examine whether women have higher tau burden than men, and whether tau differences are independent of amyloid β (Aβ) burden. We...
