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Dementia

Lifestyle affects amyloid burden and cognition differently in men and women.

May 23, 2022

Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed interrelationships of factors and sex effects. While con...

Artesunate restores mitochondrial fusion-fission dynamics and alleviates neuronal injury in Alzheimer's disease models.

May 23, 2022

Alzheimer's disease (AD) remains a leading cause of dementia and no therapy that reverses underlying neurodegeneration is available. Recent studies suggest the protective role of artemisinin, an antim...

#VisualAbstract: Increased Physical Activity Is a Long-Term Protective Factor for Dementia

May 20, 2022

1. Physical activity was significantly associated with a decreased incidence of all-cause dementia and Alzheimer’s disease, irrespective of follow-up length, baseline age and study quality. 2...

High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner.

May 16, 2022

Approximately 70% of Alzheimer's disease (AD) patients have co-morbid vascular contributions to cognitive impairment and dementia (VCID); this highly prevalent overlap of dementia subtypes is known as...

Design and Synthesis of Five-membered Heterocyclic Derivatives of Istradefylline with Comparable Pharmacological Activity.

May 16, 2022

Parkinson's disease (PD) is a common degenerative disease of the central nervous system among the elderly. Istradefylline, an FDA-approved adenosine A receptor antagonist (anti-PD drug), has good effi...

SUN11602, a bFGF mimetic, modulated neuroinflammation, apoptosis and calcium-binding proteins in an in vivo model of MPTP-induced nigrostriatal degeneration.

May 09, 2022

Parkinson's disease (PD) is the second most frequent neurodegenerative disease. PD etiopathogenesis is multifactorial and not yet fully known, however, the scientific world advised the establishment o...

PIASA, a novel peptide, prevents SH-SY5Y neuroblastoma cells against rotenone-induced toxicity.

May 02, 2022

This investigation explored the neuroprotective effect of PIASA a newly designed peptide - VCSVY in in-silico and in opposition to rotenone stimulated oxidative stress, mitochondrial dysfunction, and ...

Current trends in blood biomarker detection and imaging for Alzheimer's disease.

Apr 25, 2022

Alzheimer's disease (AD) is a neurodegenerative disease that causes cognitive impairments in areas such as memory, language, and reasoning. Currently, a definitive diagnosis of AD is based on histolog...

Static and dynamic disorder in Aβ40 fibrils.

Apr 25, 2022

Deposition of Aβ aggregates in the form of amyloid fibrils is a pathological hallmark of Alzheimer's disease. Understanding the structure and dynamics of Aβ fibrils is important for delineating the ...

Sensor-based gait analysis in the premotor stage of LRRK2 G2019S-associated Parkinson's disease.

Apr 18, 2022

There is a need for biomarkers to monitor the earliest phases of Parkinson's disease (PD), especially in premotor stages. Here, we studied whether there are early gait alterations in carriers of the G...

Breaking the flow of thought: Increase of empty pauses in the connected speech of people with mild and moderate Alzheimer's disease.

Apr 11, 2022

The profile of spontaneous speech in Alzheimer's disease (AD) includes increased pausing as a window into cognitive decline. We here aimed to further characterize the pausing profile of AD by linking ...

Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.

Apr 11, 2022

The incorporation of the fluorine motif is a strategy widely applied in drug design for modulating the activity, physicochemical parameters, and metabolic stability of chemical compounds. In this stud...

Safety and pharmacokinetics of multiple dosing with inhalable apomorphine (AZ-009), and its efficacy in a randomized crossover study in Parkinson's disease patients.

Apr 04, 2022

Apomorphine is used to treat OFF periods in Parkinson's disease (PD) patients. AZ-009 is a novel apomorphine formulation that delivers a thermally-generated aerosol to the deep lung via inhalation wit...

Ethnic differences in the frequency of β-amyloid deposition in cognitively normal individuals.

Apr 04, 2022

We investigated which factors might explain the differences between the frequencies of brain β-amyloid (Aβ) deposition in Korean and European cognitively normal individuals (CNs). We recruited 434 K...

The pathogenesis and treatment mechanism of Parkinson's disease from the perspective of traditional Chinese medicine.

Mar 28, 2022

Parkinson's disease (PD) is the second most common neurodegenerative disease with no treatment currently available to modify its progression. Traditional Chinese medicine (TCM) has gained attention fo...

HDAC1/MAO-B dual inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids.

Mar 21, 2022

A series of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids inhibitors combining the typical pharmacophores of hydroxamic acid/o-aminobenzamide and propargylamine were designed and synthesiz...

Parameters from site classification to harmonize MRI clinical studies: Application to a multi-site Parkinson's disease dataset.

Mar 21, 2022

Multi-site MRI datasets are crucial for big data research. However, neuroimaging studies must face the batch effect. Here, we propose an approach that uses the predictive probabilities provided by Gau...

Effect of comorbid Parkinson's disease and Parkinson's disease dementia on the course of idiopathic normal pressure hydrocephalus.

Mar 14, 2022

The objective of this study was to analyze the effect of concomitant Parkinson's disease (PD) and PD dementia (PD/PDD) on the course of idiopathic normal pressure hydrocephalus (iNPH), especially as r...

Spatial covariance analysis of FDG-PET and HMPAO-SPECT for the differential diagnosis of dementia with Lewy bodies and Alzheimer's disease.

Mar 07, 2022

We investigated diagnostic characteristics of spatial covariance analysis (SCA) of FDG-PET and HMPAO-SPECT scans in the differential diagnosis of dementia with Lewy bodies (DLB) and Alzheimer's diseas...

Mitochondrial ribosomal protein genes connected with Alzheimer's and tellurite toxicity.

Feb 28, 2022

Mitochondrial diseases are a group of genetic disorders characterized by dysfunctional mitochondria. Within eukaryotic cells, mitochondria contain their own ribosomes, which synthesize small amounts o...