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Pain Management

Relationship Between Decreased Cortisol and Development of Chronic Pain in Traumatically Injured.

Nov 01, 2021

The relationship between pain and stress is widely accepted, yet the underlying neuroendocrine mechanisms are poorly understood. Cortisol secretion during a stress response, may distract attention fro...

INCB84344-201: Ponatinib and steroids in frontline therapy of unfit patients with Ph+ acute lymphoblastic leukemia.

Oct 18, 2021

Tyrosine kinase inhibitors have improved survival for patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis for old or unfit patients remains poor...

Decision tree outcome prediction of acute acetaminophen exposure in the United States: a study of 30,000 cases from the National Poison Data System.

Oct 18, 2021

Acetaminophen is one of the most commonly used analgesic drugs in the United States. However, the outcomes of acute acetaminophen overdose might be very serious in some cases. Therefore, prediction of...

Autofluorescent imprint of chronic constriction nerve injury identified by deep learning.

Oct 11, 2021

Our understanding of chronic pain and the underlying molecular mechanisms remains limited due to a lack of tools to identify the complex phenomena responsible for exaggerated pain behaviours. Furtherm...

Use of in vitro metabolomics in NRK cells to help predicting nephrotoxicity and differentiating the MoA of nephrotoxicants.

Oct 11, 2021

We describe a strategy using an in vitro metabolomics assay with tubular rat NRK-52E cells to investigate the Modes of Action (MoAs) of nephrotoxic compounds. Chemicals were selected according to thei...

Early-learners' expectations of and experience with IPE: A multi-institutional qualitative study.

Oct 04, 2021

Multi-institutional qualitative studies are scarce within the interprofessional education (IPE) literature; such a report would provide comprehensive evidence for the application of interprofessional ...

Assessment of Central Sensitization in Breast Cancer Survivors: Convergent Validity and Use of the Central Sensitization Inventory (CSI) and Its Short-Form as a Clustering Tool.

Sep 27, 2021

The Central Sensitization Inventory (CSI) measurement properties in patients having nonspecific, noncancer pain are well-established. However, studies examining the reliability and validity of either ...

Screening for Copy Number Variations of the 15q13.3 Hotspot in Gene and Expression in Patients with Migraines.

Sep 27, 2021

a migraine is a neurological disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated. We investigated the effects of the CNV and gene expression at the location ...

Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration.

Sep 20, 2021

Paracetamol promotes early closure of patent ductus arteriosus (PDA), and it may affect inflammation after preterm birth.The aim of this study was to evaluate the association between paracetamol treat...

Complications and prognosis associated with intra-tympanic steroid injection to treat sudden sensorineural hearing impairment.

Sep 20, 2021

The purpose of this study was to measure the incidence of complications in sudden sensorineural hearing loss (SSNHL) patients treated with intra-tympanic steroid injection (ITSI) and compare hearing r...

Wnt signaling: A prospective therapeutic target for chronic pain.

Sep 06, 2021

Despite the rapid advance over the past decades to design effective therapeutic pharmacological interventions, chronic pain remains to be an unresolved healthcare concern. Long term use of opioids, th...

CME/CE: Treating Fibromyalgia Pain With Lidocaine

Aug 30, 2021

This course discusses a study that sought to determine the effect of escalating doses of IV lidocaine with or without magnesium on pain level and duration of relief in patients with fibromyalgia....

Hodgkin Lymphoma Presenting With Spinal Cord Compression: Challenges for Diagnosis and Initial Management.

Aug 26, 2021

Hodgkin lymphoma (HL) can present with extra-nodal disease, but spinal cord compression is exceptionally rare. We describe a 15-year-old presenting with hip/back pain with normal initial examination. ...

Was it something I ate? Understanding the bidirectional interaction of migraine and appetite neural circuits.

Aug 26, 2021

Migraine attacks can involve changes of appetite: while fasting or skipping meals are often reported triggers in susceptible individuals, hunger or food craving are reported in the premonitory phase. ...

The effects of pain and a secondary task on postural sway during standing.

Aug 23, 2021

Pain impairs available cognitive resources and somatosensory information, but its effects on postural control during standing are inconclusive. The aim of this study was to investigate whether postura...

Biomarker responses induced by bisphenol A on spermatogenesis in a Neotropical teleost fish are temperature-dependent.

Aug 23, 2021

Bisphenol A (BPA) is an organic synthetic compound used in the plastic industry with endocrine disrupting activity. Although it is frequently found in surface waters, few studies have investigated its...

Combined nerve, vessel, and tendon injuries of the volar wrist: Multidisciplinary treatment and functional outcomes.

Aug 19, 2021

The superficial location of critical structures, including tendons, nerves and vessels, in the volar surface of the wrist makes them vulnerable to penetrating trauma. Extensive injuries to these struc...

Battle of the appraisals: Pain-related Injustice versus Catastrophizing as Mediators in the Relationship between Pain Intensity and 3-month Outcomes in Adolescents with Chronic Pain.

Aug 19, 2021

Pain appraisals are closely tied to pain and functional outcomes. Pain-related injustice and pain catastrophizing appraisals have both been identified as important cognitive-emotional factors in the p...

Tinnitus & Subjective Hearing Loss More Common in Migraine

Aug 17, 2021

“Tinnitus is a condition that affects approximately 10% of the adult population in the United States and can diminish one’s quality of life,” explains Hamid R. Djalilian, MD. “To date, there a...

A comparative study of Thai massage and muscle energy technique for chronic neck pain: A single-blinded randomized clinical trial.

Aug 16, 2021

Myofascial pain syndrome (MPS) is the most common form of muscle disorders. Traditional Thai massage (TM) and muscle energy (ME) technique have been used to treat patients with MPS for long time but h...