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OB/GYN General

When a Stroke is not Just a Stroke: Meningitis with Ventriculitis and Vasculitis: A Case Report.

Feb 28, 2020

Community-acquired ventriculitis is considered a rare condition. Central nervous system (CNS) infection due to gram-negative bacilli is usually associated with previous neurosurgical interventions. T...

The oxidative fumarase FumC is a key contributor for E. coli fitness under iron-limitation and during UTI.

Feb 28, 2020

The energy required for a bacterium to grow and colonize the host is generated by metabolic and respiratory functions of the cell. Proton motive force, produced by these processes, drives cellular mec...

Case of catatonia misdiagnosed with coma.

Feb 25, 2020

Catatonia is a state of high-degree psychomotor inhibition in which patients often maintain a constant fixed posture, and generally have unconscious obstacles and various reflex preservation. Patients...

Evaluation of Renal Disease in Patients With Cirrhosis.

Feb 25, 2020

Renal dysfunction in cirrhosis is common and is associated with increased mortality. Identifying and treating reversible causes of renal disease can significantly improve outcomes. The etiology, appro...

Evaluation of durability of a single-dose of the bivalent HPV vaccine: the CVT Trial.

Feb 25, 2020

Investigate the durability of vaccine efficacy (VE) against HPV16/18 infections and antibody response among non-randomized women who received a single-dose of the bivalent HPV vaccine compared to wome...

Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: the CVT Trial.

Feb 25, 2020

The Costa Rica HPV Vaccine Trial (CVT) has documented cross-protection of the bivalent HPV vaccine against HPV31/33/45 up to seven years after vaccination, even with one dose of the vaccine. However, ...

Virus-associated anterior uveitis and secondary glaucoma: Diagnostics, clinical characteristics, and surgical options.

Feb 25, 2020

In this retrospective, single-center, observational study, we compared the clinical characteristics, analyzed the glaucoma development, and the glaucoma surgery requirement mediators in patients with ...

Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis.

Feb 25, 2020

We evaluated the efficacy and safety of upadacitinib, an oral selective inhibitor of Janus kinase 1, as induction therapy for ulcerative colitis (UC).We performed a multicenter, double-blind, phase 2b...

The Value of Parental Testing by Next-Generation Sequencing Includes the Detection of Germline Mosaicism.

Feb 25, 2020

When a potential disease-causing variant is detected in a proband, parental testing is used to determine the mode of inheritance. This study demonstrates that next-generation sequencing (NGS) is uniqu...

Application of a human mesoderm tissue elongation system in vitro derived from human induced pluripotent stem cells to risk assessment for teratogenic chemicals.

Feb 25, 2020

Toxic compounds from the mother's diet and medication in addition to genetic factors and infection during pregnancy remain risks for various congenital disorders and misbirth. To ensure the safety of ...

Epidemiology of pre-eclampsia in the Republic of Kazakhstan: Maternal and neonatal outcomes.

Feb 25, 2020

Pre-eclampsia (PE) still significantly contributes to maternal and neonatal morbidity and mortality. This study aimed at evaluation of the prevalence of PE among Kazakhstani women and on elucidation o...

Pregnancy in Advanced Kidney Disease: Clinical Practice Considerations on a Challenging Combination.

Feb 25, 2020

Thanks to the advances in care, pregnancy is now attainable for the majority of young female CKD patients, although it is still a high-risk endeavor. Clinical decision-making in these cases is impacte...

Role of Frozen Section in Surgical Management of Ovarian Neoplasm.

Feb 25, 2020

Cancers of the adnexae, including ovarian and fallopian tube, constitute the eighth most common cancers among women worldwide. Surgery remains the cornerstone in the management of ovarian cancer. Intr...

Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer.

Feb 25, 2020

The data on the phenotypes associated with some rare germline mutations in Chinese breast cancer patients are limited. The difference in somatic mutation profiles in breast cancer patients with germli...

The contribution of germline predisposition gene mutations to clinical subtypes of invasive breast cancer from a clinical genetic testing cohort.

Feb 25, 2020

The germline cancer predisposition genes associated with increased risk of each clinical subtype of breast cancer, defined by estrogen receptor (ER), progesterone receptor (PR), and HER2, are not well...

Improved stability of siRNA-loaded lipid nanoparticles prepared with a PEG-monoacyl fatty acid facilitates ligand-mediated siRNA delivery.

Feb 25, 2020

Peptide modification is a popular strategy for developing an active targeting lipid nanoparticle (LNP). In modifying the surface of an LNP with a peptide, the sequence and structure of the peptide str...

Detection of BRCA1/2 Large Genomic Rearrangement including BRCA1 Promoter-Region Deletions using Next-Generation Sequencing.

Feb 25, 2020

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) have been conventionally analyzed by Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA). Nowadays, next-generation sequencing...

Is midlife metabolic syndrome associated with cognitive function change? The Study of Women's Health Across the Nation.

Feb 25, 2020

Metabolic syndrome (MetS) affects cognitive function in late-life, particularly in women. But longitudinal research is scarce on associations of MetS with cognitive function during midlife.Objective w...

A cumulative index of exposure to endogenous estrogens and breast cancer by molecular subtypes in northern Mexican women.

Feb 25, 2020

To evaluate breast cancer (BC) molecular subtypes association with reproductive characteristics and an index of cumulative exposure to endogenous estrogens (EEI) in Mexican women.We performed a study ...

Ovariectomy-induced depressive-like behavior and brain glucose metabolism changes in female rats are not affected by chronic mild stress.

Feb 25, 2020

The increased incidence of depression in women going through peri-menopause suggests that fluctuations in estrogen levels may increase the risk of developing depression. Nonetheless, this psychiatric ...

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