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Prostate Cancer

IsoPSA Shows Notable Diagnostic Accuracy in Detecting Prostate Cancer

Jul 20, 2022

The IsoPSA biomarker displays superior diagnostic accuracy in the early detection of prostate cancer, thereby helping to avoid unnecessary prostate biopsies. There is a growing population of pa...

High intratumoral plasma cells content in primary prostate cancer defines a subset of tumors with potential susceptibility to immune-based treatments.

May 16, 2022

Data on advanced prostate cancer (PCa) suggest more prior systemic therapies might reduce tumor immune responsiveness. In treatment-naïve primary PCa, recent work correlated intratumoral plasma cell ...

Diagnostic yield and outcome of transrectal ultrasound-guided prostate biopsy in Sri Lanka.

May 16, 2022

The study was aimed to determine the diagnostic yield and outcome of transrectal ultrasound-guided prostate biopsy (TRUSPB) in a cohort of Sri Lankan men. A prospective study was conducted among 333 (...

Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells.

May 09, 2022

Accumulating evidence supports that prostate cancer stem-like cells (PCSCs) play significant roles in therapy resistance and metastasis of prostate cancer. Many studies also show that nitric oxide (NO...

Machine learning algorithms to estimate 10-Year survival in patients with bone metastases due to prostate cancer: toward a disease-specific survival estimation tool.

May 02, 2022

Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to esti...

Clinical Validation of a Circulating Tumor Cell Assay Using Density Centrifugation and Automated Immunofluorescence Microscopy.

Apr 25, 2022

The US Food and Drug Administration (FDA)-approved CELLSEARCH assay (Menarini Silicon Biosystems) for circulating tumor cells (CTCs) relies on expression of an epithelial cell adhesion molecule to enr...

Binding of pleiotrophin to cell surface nucleolin mediates prostate cancer cell adhesion to osteoblasts.

Apr 25, 2022

Pleiotrophin (PTN) is a growth factor that appears to play an important role in prostate cancer growth and angiogenesis. We have previously shown that decreased PTN expression in human prostate cancer...

The Diagnostic Performance of 18F-PSMA-1007 PET/CT in Prostate Cancer Patients with Early Recurrence after Definitive Therapy with a PSA <10 ng/ml.

Apr 18, 2022

The prostate bed is one of the common sites of early recurrence of prostate cancer. The currently used PSMA ligands (Ga-PSMA-11 and Tc-PSMA) undergo early urinary clearance resulting in interfering ph...

The role of Ga PSMA PET/CT imaging in Lu PSMA treatment planning in metastatic castration-resistant prostate cancer.

Apr 11, 2022

Lutetium-177 (Lu) prostate-specific membrane antigen (Lu PSMA) is a novel targeted treatment for patients with metastatic castration-resistant prostate cancer (CRPC). The purpose of the study was to d...

Click-on fluorescence detectors: using robotic surgical instruments to characterize molecular tissue aspects.

Apr 11, 2022

Fluorescence imaging is increasingly being implemented in surgery. One of the drawbacks of its application is the need to switch back-and-forth between fluorescence- and white-light-imaging settings a...

Efficacy and safety exposure-response relationships of apalutamide in patients with metastatic castration-sensitive prostate cancer: results from the phase 3 TITAN study.

Apr 04, 2022

Apalutamide plus androgen-deprivation therapy (ADT) has been approved for treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC) based on data from phase 3 TITAN study. Thi...

Interaction of TLK1 and AKTIP as a Potential Regulator of AKT Activation in Castration-Resistant Prostate Cancer Progression.

Apr 04, 2022

Prostate cancer (PCa) progression is characterized by the emergence of resistance to androgen deprivation therapy (ADT). AKT/PKB has been directly implicated in PCa progression, often due to the loss ...

Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveals the potential role of ketogenesis to slow tumor growth: a secondary analysis of the CAPS2 diet trial.

Mar 28, 2022

Systemic treatments for prostate cancer (PC) have significant side effects. Thus, newer alternatives with fewer side effects are urgently needed. Animal and human studies suggest the therapeutic poten...

H-ProSeg: Hybrid ultrasound prostate segmentation based on explainability-guided mathematical model.

Mar 28, 2022

Accurate and robust prostate segmentation in transrectal ultrasound (TRUS) images is of great interest for image-guided prostate interventions and prostate cancer diagnosis. However, it remains a chal...

Outcome of primary androgen deprivation therapy in super-elderly men with localized high-risk prostate cancer.

Mar 14, 2022

The purpose of this study is to provide certain data on clinical outcome of primary androgen deprivation therapy in men over 80 years of age with localized high-risk prostate cancer. This study includ...

Prognostic Value of Long Noncoding RNA SNHG11 in Patients with Prostate Cancer.

Mar 14, 2022

The present study was aimed to explore the prognostic value of long noncoding RNA SNHG11 in prostate cancer, study its expression, and assess its effect on tumor progression. One hundred and twenty pr...

Race Differences in Telomere length in benign prostate biopsies and subsequent risk of prostate cancer.

Mar 07, 2022

Telomere shortening is linked to aging and may be associated with increased risk for cancer. Most cancer studies have used telomere length in leukocytes rather than in the target tissue of cancer orig...

Real-world survival outcomes of adding docetaxel or abiraterone in patients with high-volume metastatic castration-sensitive prostate cancer: historically controlled, propensity score matched comparison with androgen deprivation therapy.

Feb 28, 2022

This study investigated the impact of treatment intensification with upfront docetaxel (DOC) or abiraterone (ABI) plus prednisolone on survival outcomes in patients with metastatic castration-sensitiv...

Acquired and congenital spinal cord injury is associated with lower likelihood of PSA screening.

Feb 21, 2022

Studies have demonstrated lower prevalence of prostate cancer among patients with spinal cord injury but more advanced stage at diagnosis. However, there is a lack of literature on prostate cancer scr...

Effect of Radiation Treatment at a High-Volume Center on Outcomes in Intermediate-Risk Prostate Cancer: An Analysis of the National Cancer Database.

Feb 21, 2022

To investigate the effect of radiation treatment at a high-volume center on overall survival in men with intermediate-risk prostate cancer.From 2004-2015, 430,347 patients with intermediate-risk prost...