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Flu

Genetic variability of influenza A virus in pigs at weaning in Midwestern United States swine farms.

Mar 19, 2020

Suckling piglets play an important role at maintaining influenza A virus (IAV) infections in breeding herds and disseminating them to other farms at weaning. However, the role they play at weaning to ...

Digestive Symptoms Reported for About Half of COVID-19 Patients

Mar 19, 2020

THURSDAY, March 19, 2020 (HealthDay News) -- Patients with coronavirus 2019 (COVID-19) frequently have digestive symptoms, and those with digestive symptoms have a worse clinical outcome, according to...

Association of specific viral infections with childhood asthma exacerbations.

Mar 10, 2020

Asthma exacerbations may occur due to a variety of triggers including respiratory viruses. The aim of this study was to determine the role of particular viral infections in asthma exacerbations in chi...

The incidence of lower respiratory tract infections and pneumococcal vaccination status in adults in flemish primary care.

Mar 10, 2020

Pneumococcal vaccination coverage of adults at risk for pneumococcal disease is below recommended levels. There is no observational data on pneumococcal vaccination and the incidence of lower respirat...

Transmission of respiratory tract infections at mass gathering events.

Mar 10, 2020

Mass gathering events bring people from across all continents increasing the risk of spread of aerosol transmissible respiratory tract infections. Respiratory tract infections for instance in pilgrims...

Magnetic Particle Spectroscopy (MPS) for Detection of Influenza A Virus Subtype H1N1.

Mar 10, 2020

Magnetic nanoparticles (MNPs) with proper surface functionalization have been extensively applied as labels for magnetic immunoassays, carriers for controlled drug/gene delivery, tracers and contrasts...

Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults: A Randomized Clinical Trial.

Mar 10, 2020

FLU-v is a broad-spectrum influenza vaccine that induces antibodies and cell-mediated immunity.To compare the safety, immunogenicity, and exploratory efficacy of different formulations and dosing regi...

Preparation, characterization and evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization.

Feb 28, 2020

For efficient mucosal vaccine delivery, nanoparticulate antigens are better taken by microfold cells in the nasal associated lymphoid tissue and also dendritic cells. Nanoparticles based on polymers s...

Understanding influenza vaccination among Portuguese elderly: the social ecological framework.

Feb 28, 2020

This study intended to identify and quantify the social ecological model (SEM) levels associated to seasonal IV uptake in the Portuguese elderly population. Data from the 2014 National Health Survey w...

Prophylactic antiviral activity of sulfated glycomimetic oligomers and polymers.

Feb 28, 2020

In this work, we investigate the potential of highly sulfated synthetic glycomimetics to act as inhibitors of viral binding/infection. Our results indicate that both, long chain glycopolymers and shor...

From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptor and RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus.

Feb 28, 2020

Males and females respond to pathogens differently and exhibit significantly different frequencies of autoimmune disease. For example, vaccinated adult females control influenza virus better than male...

Evolutionary dynamics of influenza B strains detected from paediatric acute respiratory infections in central Vietnam.

Feb 28, 2020

Influenza virus B belongs to the family Orthomyxoviridae with segmented negative-sense RNA genomes. Since 1970s, influenza B has diverged intoVictoria and Yamagata, which differs in antigenic and evol...

Role of Live-Duck Movement Networks in Transmission of Avian Influenza, France, 2016-2017.

Feb 25, 2020

The relative roles that movement and proximity networks play in the spread of highly pathogenic avian influenza (HPAI) viruses are often unknown during an epidemic, preventing effective control. We us...

Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury.

Feb 25, 2020

Pulmonary endothelial cells (ECs) are an essential component of the gas exchange machinery of the lung alveolus. Despite this, the extent and function of lung EC heterogeneity remains incompletely und...

Comparative Severity of Influenza A and B Infections in Hospitalized Children.

Feb 25, 2020

Influenza A viruses are conventionally thought to cause more severe illnesses than B viruses, but few studies with long observation periods have compared the clinical severity of A and B infections in...

Influenza virus NS1- C/EBPβ gene regulatory complex inhibits RIG-I transcription.

Feb 25, 2020

Influenza virus non-structural protein 1 (NS1) counteracts host antiviral innate immune responses by inhibiting Retinoic acid inducible gene-I (RIG-I) activation. However, whether NS1 also specificall...

Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors.

Feb 25, 2020

From our research group, it was noticed that oseltamivir derivatives targeting 150-cavity of neuraminidase enzyme (NA) could significantly increase antiviral activity. Thus, we further enriched the C5...

Eosinophils, Basophils, and Type 2 Immune Microenvironments in COPD-Affected Lung Tissue.

Feb 17, 2020

Although elevated blood or sputum eosinophils are present in many patients with chronic obstructive pulmonary disease (COPD), uncertainties remain regarding the anatomical distribution pattern of lung...

Repurposing the Psoriasis Drug Oxarol to an ointment adjuvant for the influenza vaccine.

Feb 17, 2020

Aluminum precipitates have long been used as adjuvants for human vaccines, but there is a clear need for safer and more effective adjuvants. Here we report in a mouse model that the Psoriasis drug Oxa...

The Dutch influenza vaccination policy and medication use, outpatient visits, hospitalization and mortality at age 65.

Feb 17, 2020

Our objective was to obtain estimates of the impact of the Dutch vaccination programme on medication use, outpatient visits, hospitalization and mortality at age 65.We linked population-wide mortality...