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Critical Care General

Risk factors associated with the progression of COVID-19 in elderly diabetes patients.

Nov 26, 2020

To describe the clinical characteristics and risk factors associated with the progression of COVID-19 in elderly diabetes patients.This was a retrospective cohort study, including elderly COVID-19 pat...

The impact of a stewardship programme on antibiotic administration in community-acquired pneumonia: results from an observational before-after study.

Nov 26, 2020

A majority of patients with community-acquired pneumonia (CAP) receive antibiotics. According to the evidence, 5-7 days of treatment should be sufficient for most patients. Many, however, are treated ...

Emerging challenges in the evaluation of fever in cancer patients at risk of febrile neutropenia in the era of COVID-19: a MASCC position paper.

Nov 26, 2020

Patients with cancer are at higher risk of more severe COVID-19 infection and have more associated complications. The position paper describes the management of cancer patients, especially those recei...

Leukopenia and Neutropenia at Birth and Sepsis in Preterm Neonates of <32 Weeks' Gestation.

Nov 26, 2020

 This study aimed to evaluate associations between leukopenia or neutropenia at birth and risk of sepsis in very preterm neonates. We conducted a retrospective unmatched cohort study of neonates o...

FAM96A knockout promotes alternative macrophage polarisation and protects mice against sepsis.

Nov 26, 2020

Sepsis is an intractable clinical syndrome characterised by organ dysfunction when the body over-responds to an infection. Sepsis has a high fatality rate and lacks effective treatment. Family with se...

ADMINISTRATION OF VALPROIC ACID IN CLINICALLY APPROVED DOSE IMPROVES NEUROLOGIC RECOVERY AND DECREASES BRAIN LESION SIZE IN SWINE SUBJECTED TO HEMORRHAGIC SHOCK AND TRAUMATIC BRAIN INJURY.

Nov 26, 2020

Traumatic brain injury (TBI) and hemorrhage remain the leading causes of death after trauma. We have previously shown that a dose of Valproic Acid (VPA) at (150 mg/kg) can decrease brain lesion size &...

How to assess visual function in acquired brain injury-Asking is not enough.

Nov 26, 2020

Acquired brain injury affects many brain areas and causes a range of dysfunctions including vision-related issues. These issues can have negative impacts on rehabilitation progress and activities of d...

Predictors of participation and quality of life following major traumatic injuries in childhood: a systematic review.

Nov 26, 2020

Review the literature on predictors of participation and quality of life in children and young people who sustained a traumatic brain injury (TBI), spinal cord injury (SCI), and/or multi-trauma in a m...

Insights into heart failure hospitalizations, management, and services during and beyond COVID-19.

Nov 26, 2020

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The clinical presentation of this virus mainly manifests in the respiratory system but may also lead t...

When the At-Risk Do Not Develop Heart Failure: Understanding Positive Deviance Among Postmenopausal African-American and Hispanic Women.

Nov 26, 2020

African-American and Hispanic postmenopausal women have the highest risk for heart failure (HF) compared to other races, but HF prevalence is lower than expected in some national cohorts. It is unknow...

Uric acid aggravates myocardial ischemia-reperfusion injury via ROS/NLRP3 pyroptosis pathway.

Nov 26, 2020

The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome activation-mediated pyroptosis pathway has been linked to myocardial ischemia-reperfusion (MI/R) injury. This study explore...

ACUTE UNLOADING EFFECTS OF SILDENAFIL ENHANCE RIGHT VENTRICULAR-PULMONARY ARTERY COUPLING IN HEART FAILURE.

Nov 26, 2020

Phosphodiesterase-5A inhibitors (PDE5i) are sometimes used in patients with advanced HFrEF prior to heart transplant or LVAD to reduce RV afterload and mitigate the risk of right HF. Conflicting evide...

Increased risk of ischemic heart disease and diabetes in inflammatory bowel disease.

Nov 26, 2020

 Previous studies showed inconsistent results regarding associations between inflammatory bowel disease (IBD) and risk of ischemic heart disease (IHD) and diabetes. The present study aimed to make a...

Therapeutic Potential of Nutraceuticals to Protect Brain after Stroke.

Nov 23, 2020

Stroke leads to significant neuronal death and long-term neurological disability due to synergistic pathogenic mechanisms. Stroke induces a change in eating habits and in many cases, leads to undernut...

Effect of acute and subchronic administration of (R)-WIN55,212-2 induced neuroprotection and anti inflammatory actions in rat retina: CB1 and CB2 receptor involvement.

Nov 23, 2020

Cannabinoids have been shown to protect the retina from ischemic/excitotoxic insults. The aim of the present study was to investigate the neuroprotective and anti-inflammatory properties of the synthe...

Is obesity associated with short-term revision after total knee arthroplasty? An analysis of 121,819 primary procedures from the Dutch Arthroplasty Register.

Nov 23, 2020

The prevalence of obesity is increasing. The association with knee osteoarthritis is well documented, resulting in the population requesting total knee arthroplasty (TKA) for invalidating symptoms to ...

High-performance low field MRI enables visualization of persistent pulmonary damage after COVID-19.

Nov 23, 2020

The outbreak of coronavirus disease 2019 (COVID-19) with the origin of the spread assumed to be located in Wuhan, China, began in December 2019, and is continuing until now. With the COVID-19 pandemic...

Ambient PM and its chemical constituents on lifetime-ever pneumonia in Chinese children: A multi-center study.

Nov 23, 2020

The long-term effects of ambient PM and chemical constituents on childhood pneumonia were still unknown. A cross-sectional study was conducted in 30,315 children in the China Children, Homes, Health (...

Prevalence, incidence, and outcomes across cardiovascular diseases in homeless individuals using national linked electronic health records.

Nov 23, 2020

The risk and burden of cardiovascular disease (CVD) are higher in homeless than in housed individuals but population-based analyses are lacking. The aim of this study was to investigate prevalence, in...

C-reactive protein- and clinical symptoms-guided strategy in term neonates with early-onset sepsis reduced antibiotic use and hospital stay: a quality improvement initiative.

Nov 23, 2020

Early-onset sepsis (EOS) is a potentially life-threatening complication of birth. Clinical symptoms are often unspecific and biomarkers have low predictive values for EOS. Therefore, clinical suspicio...

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