Advertisement

Critical Care General

Long-term efficacy, safety, and cumulative retention rate of antitumor necrosis factor-alpha treatment for patients with Behcet's uveitis: A systematic review and meta-analysis.

Feb 26, 2024

This study aims to evaluate the long-term efficacy, safety, and cumulative retention rate of antitumor necrosis factor-alpha (anti-TNF-α) therapy for patients with Behcet's uveitis (BU) using meta-an...

Aetiology and use of antibiotics in pregnancy-related infections: results of the WHO Global Maternal Sepsis Study (GLOSS), 1-week inception cohort.

Feb 26, 2024

Pregnancy-related infections are important contributors to maternal sepsis and mortality. We aimed to describe clinical, microbiological characteristics and use of antibiotics by source of infection a...

Non-pharmacological interventions for sleep disruptions and fatigue after traumatic brain injury: a scoping review.

Feb 26, 2024

The aim of this study was to conduct a scoping review to determine the nature, variety, and volume of empirical evidence on nonpharmacological interventions for sleep disturbances with potential impli...

Detecting feigned cognitive impairment using pupillometry on the Warrington Recognition Memory Test for Words.

Feb 26, 2024

Pupillometry provides information about physiological and psychological processes related to cognitive load, familiarity, and deception, and it is outside of conscious control. This study examined pup...

An association between heart rate variability and incident heart failure in an elderly cohort.

Feb 26, 2024

Early identification of individuals at risk of developing heart failure (HF) may improve poor prognosis. A dominant sympathetic activity is common in HF and associated with worse outcomes; however, le...

CLINICIAN AND PATIENT IDENTIFIED SOLUTIONS TO REDUCE THE FRAGMENTATION OF POST-ICU CARE IN AUSTRALIA.

Feb 26, 2024

Critical care survivors experience multiple care transitions, with no formal follow-up care pathway.What are the potential solutions to improve the communication between treating teams and integration...

Barriers and Facilitators of Surrogates Providing Consent for Critically Ill Patients in Clinical Trials. A Qualitative Study.

Feb 26, 2024

Enrollment into critical care clinical trials is often hampered by the need to rely on surrogate decision-makers. To identify potential interventions facilitating enrollment into critical care clinica...

Prolonged versus intermittent β-lactam infusion in sepsis: a systematic review and meta-analysis of randomized controlled trials.

Feb 19, 2024

The two latest studies on prolonged versus intermittent use of β-lactam antibiotics in patients with sepsis did not reach consistent conclusions, further contributing to the controversy surrounding t...

Tetrahydrocurcumin Protects Against GSK3β/PTEN/PI3K/Akt-Mediated Neuroinflammatory Responses and Microglial Polarization Following Traumatic Brain Injury.

Feb 19, 2024

Tetrahydrocurcumin (THC) and microglial polarization play crucial roles in neuroprotection during traumatic brain injury (TBI). However, whether THC regulates microglial polarization in TBI is unknown...

Deficits in the pupillary response associated with abnormal visuospatial attention allocation in mild traumatic brain injury.

Feb 19, 2024

The ability to allocate visual attention is known to be impaired in patients with mild traumatic brain injury (mTBI). In the present study, we investigated a possible neural correlate of this cognitiv...

Lower left atrial function in young individuals with type 1 diabetes mellitus compared to healthy controls: an echocardiographic study.

Feb 19, 2024

In adulthood, individuals with type 1 diabetes mellitus may develop a condition of heart failure with preserved ejection fraction. However, subclinical changes to the heart in diabetes are likely to o...

The Association between Malnutrition and High Protein Treatment on Outcomes in Critically Ill Patients: A Post Hoc Analysis of the EFFORT Protein Randomized Trial.

Feb 19, 2024

Pre-existing malnutrition in critically ill patients is associated with adverse clinical outcomes. Malnutrition can be diagnosed with the Global Leadership Initiative on Malnutrition using parameters ...

Achieving Goals of Care Decisions in Chronic Critical Illness: A Multi-Institutional Qualitative Study.

Feb 19, 2024

Clinicians, patients, and families alike perceive a need to improve how goals of care (GOC) decisions occur in chronic critical illness (CCI) but little is currently known about this decision making p...

Integrated multi-omic analysis identifies fatty acid binding protein 4 as a biomarker and therapeutic target of ischemia-reperfusion injury in steatotic liver transplantation.

Feb 12, 2024

Due to a lack of donor grafts, steatotic livers are used more often for liver transplantation (LT). However, steatotic donor livers are more sensitive to ischemia-reperfusion (IR) injury and have a wo...

Genetic, Immunological, and Clinical Features of 830 Patients with Mendelian Susceptibility to Mycobacterial Diseases (MSMD): A Systematic Review.

Feb 12, 2024

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare clinical syndrome characterized by vulnerability to weakly virulent mycobacterial species, including Bacillus Calmette-Guérin (BCG)...

Use of pus metagenomic next-generation sequencing for efficient identification of pathogens in patients with sepsis.

Feb 12, 2024

The positive detection rate of blood metagenomic next-generation sequencing (mNGS) was still too low to meet clinical needs, while pus from the site of primary infection may be advantageous for identi...

Incidence of tuberculosis (TB) disease in individuals diagnosed with TB infection following screening: a population-based cohort study in South Korea.

Feb 12, 2024

Limited evidence exists regarding the impact of adherence to diverse tuberculosis preventive therapy (TPT) regimens on TB risk in individuals with tuberculosis infections (TBI). This study aimed to ex...

Histological and functional assessment of a Takotsubo cardiomyopathy model established by immobilization stress.

Feb 12, 2024

Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy, resembles acute heart failure syndrome but lacks disease-specific diagnosis and treatment strategies. TTC accounts for appr...

Artificial intelligence predictive analytics in heart failure: results of the pilot phase of a pragmatic randomized clinical trial.

Feb 12, 2024

We conducted an implementation planning process during the pilot phase of a pragmatic trial, which tests an intervention guided by artificial intelligence (AI) analytics sourced from noninvasive monit...

Plasma concentrations of histidine-rich glycoprotein in primary graft dysfunction after lung transplantation.

Feb 05, 2024

Histidine-rich glycoprotein has been reported as an anti-inflammatory glycoprotein that inhibits acute lung injury in mice with sepsis and as a prognostic biomarker in patients with sepsis. We investi...

SUBSPECIALTIES

Advertisement