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Critical Care General

Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge.

Oct 15, 2020

Microglia, the resident macrophages of the brain parenchyma, are key players in central nervous system (CNS) development, homeostasis, and disorders. Distinct brain pathologies seem associated with di...

Validation of the qSOFA score compared to the CRB-65 score for risk prediction in community-acquired pneumonia.

Oct 15, 2020

The qSOFA score shows similarities to the CRB-65 pneumonia score, but its prognostic accuracy in patients with community-acquired pneumonia (CAP) has not been extensively evaluated. The aim was to val...

Are thromboelastometric and thromboelastographic parameters associated with mortality in septic patients? A systematic review and meta-analysis.

Oct 15, 2020

Thromboelastometry/elastography (ROTEM/TEG) showed promising results for diagnosis of sepsis-induced coagulopathy, but their association with the outcome is unclear. Our aim was to assess any differen...

Pharmaconutrition revisited for critically ill patients with coronavirus disease 2019 (COVID-19): Does selenium have a place?

Oct 15, 2020

Coronavirus disease 2019 (COVID-19) is a global pandemic causing one of the biggest challenges for critical care medicine. Mortality from COVID-19 is much greater in elderly men, many of whom succumb ...

Pentoxifylline, a drug with antiviral, anti-inflammatory and bronchodilatory effects may be a possible drug candidate for SARS-CoV-2.

Oct 15, 2020

In December 2019, a new coronavirus, named SARS-CoV-2, has emerged from China causing pneumonia outbreaks first in the Wuhan region and have now spread worldwide but there are still no "specific drug"...

Increased Rates of Septic Shock, Cardiac Arrest, and Mortality Associated With Chronic Steroid Use Following Anterior Cervical Discectomy and Fusion for Cervical Stenosis.

Oct 15, 2020

Anterior cervical discectomy and fusion (ACDF) is an established treatment modality for cervical spondylosis. Many patients are on immunosuppressant therapy in the management of various inflammatory s...

Epidemiology and outcome of septic arthritis in childhood: a 16-year experience and a review of literature.

Oct 15, 2020

Septic arthritis (SA) is a devastating infection with a high rate of sequelae. The aim of this retrospective study was to determine the epidemiology, clinically significant sequelae and risk factors f...

Augmenting emergency granulopoiesis with CpG conditioned mesenchymal stromal cells in murine neutropenic sepsis.

Oct 15, 2020

Patients with immune deficiencies from cancers and associated treatments represent a growing population within the intensive care unit with increased risk of morbidity and mortality from sepsis. Mesen...

Contribution of the neuropsychological assessment in concussion.

Oct 15, 2020

The neuropsychological assessment is a cornerstone in the care management of concussion or mild traumatic injury.To present the different stages of an exhaustive neuropsychological assessment explorin...

Management of unfavorable outcome after mild Traumatic Brain Injury: review of physical and cognitive rehabilitation and of psychological care in post-concussive syndrome.

Oct 15, 2020

Mild Traumatic Brain Injury (mTBI) is a public health issue with approximately 42 million people worldwide affected yearly. Most patients have a favorable short-term recovery but 10-20% are likely to ...

Hospitalized traumatic brain injury victims in France: An analysis of the French hospital discharge database for 2011-2016.

Oct 15, 2020

Traumatic brain injury (TBI) is a major public health problem because of its severity and frequency. No recent national epidemiological study on TBI victims is currently available in France.This study...

Physical activity modification in youth with congenital heart disease: a comprehensive narrative review.

Oct 15, 2020

Congenital heart disease (CHD) affects nearly 1% of births. As survival rates have dramatically improved, the majority of individuals with CHD now live into adulthood. As these patients age, they beco...

Use of critical care resources during the first 2 weeks (February 24-March 8, 2020) of the Covid-19 outbreak in Italy.

Oct 15, 2020

A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear of an imminent saturation of available ICU beds generated the notion that rationing of in...

Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice.

Oct 15, 2020

Aging is an independent risk factor for cardiovascular diseases, such as myocardial infarction due to ischemia-reperfusion injury (I/R) of the heart. Cytosolic thioredoxin (Trx) is a multifunctional r...

Lamiaceae in the treatment of cardiovascular diseases.

Oct 15, 2020

Lamiaceae (Labiatae) are an important group of medicinal plants, which have been used for treating heart disease in traditional medicine for centuries. These mainly aromatic plants are used as essenti...

Intraday effects of outdoor air pollution on acute upper and lower respiratory infections in Australian children.

Oct 15, 2020

Children's respiratory health are particularly vulnerable to outdoor air pollution, but evidence is lacking on the very acute effects of air pollution on the risk of acute upper respiratory infections...

[Effekte der Kneipp-Therapie: Ein systematischer Review der aktuellen wissenschaftlichen Erkenntnisse (2000-2019)].

Oct 15, 2020

Einleitung: Ziel dieser systematischen Übersicht war die Bewertung der verfügbaren Evidenz zur Wirkung der Kneipp-Therapie. Methoden: MEDLINE, Embase, Web of Science, Cochrane-Library und CAMbase wu...

The Role Played by Hypertension and Growing Factors.

Oct 13, 2020

This problem of Intra-Abdominal Hypertension is usually present in patients who are very ill. This is an important factor that hints about death, fatality, and mortality. The factors which are in the ...

The tale of the Masks during Covid 19

Oct 13, 2020

The outbreak of the COVID-19 has been able to take a toll on the lives of many people across the world. This is because of the reason that there is no vaccine available to cure this problem. In additi...

Can Hypoxemia be explained by Intracardia or Intrapulmonary Shunt in COVID-19?

Oct 12, 2020

Hypoxemia is the main component of COVID-19 related acute respiratory distress syndrome, however, its mechanisms are disputed, especially in patients with low respiratory system elastance (Ers). About...

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