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Critical Care General

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

Jun 11, 2020

Effective therapeutics to treat COVID-19 are urgently needed. While many investigational, approved, and repurposed drugs have been suggested, preclinical data from animal models can guide the search f...

A Novel Response to Emergency Treatment & Transport

Jun 09, 2020

Currently, Medicare fee-for-service (FFS) pays for ambulance services only when patients are transported to covered destinations, mainly the ED. This incentive of traditional ambulance transportation ...

Gastrointestinal Complications After Cardiac Surgery: Highly Morbid but Improving Over Time.

Jun 08, 2020

Gastrointestinal complications after cardiac surgery are associated with high morbidity and mortality. We sought to determine the granular impact of individual gastrointestinal complications after car...

The influence of pre-treatment on biomat development in soil treatment units.

Jun 08, 2020

Soil treatment units (STUs) receiving effluent from on-site wastewater treatment systems (OWTSs) rely on the gradual development of a microbial biomat/biozone at the infiltrative surface for optimal e...

Outcomes of stand-alone Anterior Lumbar Interbody Fusion of L5-S1 using a novel implant with anterior plate fixation.

Jun 08, 2020

Compared to other approaches, anterior lumbar interbody fusion (ALIF) is believed to be more effective at restoring segmental lordosis and reducing risks of adjacent-segment disease. It remains contro...

Nitrate contamination and source apportionment in surface and groundwater in Ghana using dual isotopes (N and O-NO) and a Bayesian isotope mixing model.

Jun 08, 2020

The rising food production to meet the growing human population has led to increased anthropogenic inputs of nutrients such as NO in groundwater and aquatic environments. Nitrate concentrations, hydro...

Apigenin, flavonoid component isolated from Gentiana veitchiorum flower suppresses the oxidative stress through LDLR-LCAT signaling pathway.

Jun 08, 2020

Flower of Gentiana veitchiorum has traditionally been used as an herbal medicine in Tibet for treatment of variola, respiratory infection, and pneumonia. However, the effective components contained in...

Alltest rapid lateral flow immunoassays is reliable in diagnosing SARS-CoV-2 infection from 14 days after symptom onset: A prospective single-center study.

Jun 08, 2020

SARS-CoV-2 infection diagnosis is challenging in patients from 2 to 3 weeks after the onset of symptoms, due to the low positivity rate of the PCR. Serologic tests could be complementary to PCR in the...

Long-term and Temporal Outcomes of Transcatheter Versus Surgical Aortic-valve Replacement in Severe Aortic Stenosis: A Meta-analysis.

Jun 08, 2020

To determine the 5-year and temporal performance of TAVR versus SAVR.TAVR has become a valuable treatment for severe aortic stenosis but the long-term safety and efficacy remain unclear.Databases were...

Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial.

Jun 08, 2020

Angiotensin-converting enzyme-2 (ACE2) expression may increase due to upregulation in patients using angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs). Because r...

Infections of Deep Hand and Wrist Compartments.

Jun 08, 2020

The human hand is the most exposed part of the body to highest risk for injuries, loss of the skin integrity, and to the inoculation of bacteria, most commonly Staphylococcus aureus, Streptococcus β-...

Delta neutrophil index as a predictive and prognostic factor for Candidemia patients: a matched case-control study.

Jun 08, 2020

Delayed antifungal therapy for candidemia leads to increased mortality. Differentiating bacterial infection from candidemia in systemic inflammatory response syndrome (SIRS) patients is complex and di...

Biomarkers of sepsis: time for a reappraisal.

Jun 08, 2020

Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In ...

Traumatic brain injury and hippocampal neurogenesis: Functional implications.

Jun 08, 2020

In the adult brain, self-renewing radial-glia like (RGL) progenitor cells have been shown to reside in the subventricular zone and the subgranular zone of the hippocampus. A large body of evidence sho...

A case series of post-transplant cyclophosphamide in unrelated donor hematopoietic transplantation for aplastic anemia.

Jun 08, 2020

Patients with severe aplastic anemia who fail immunosuppressive therapy have a dismal prognosis. Hematopoietic stem cell transplantation (HSCT) from an unrelated donor (URD) is one of the most effecti...

Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.

Jun 08, 2020

Numerous studies have examined the potential use of therapeutic gases for the treatment of various neurological disorders. Hydrogen gas, a promising neuroprotective agent, has been a focus of study du...

Sudden Cardiac Arrest with Shockable Rhythm in Patients with Heart Failure.

Jun 08, 2020

Patients with shockable sudden cardiac arrest (SCA, ventricular fibrillation/tachycardia), have significantly better resuscitation outcomes than those with non-shockable rhythms (pulseless electrical ...

What would Sérgio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?

Jun 08, 2020

Coronavirus disease 2019 (COVID-19) is an infectious disease with fast spreading all over the world caused by the SARS-CoV-2 virus which can culminate in a severe acute respiratory syndrome by the inj...

Assessment of acute treatment of hypertension in ischemic stroke patients.

Jun 08, 2020

Stroke, the most common neurologic disorder and the major cause of disability and death after heart disease causing 11.8% of the total deaths worldwide, is defined as a rapidly developing clinical sig...

Pneumonia risk and its associated factors in Parkinson's disease: A National Database Study.

Jun 08, 2020

Despite pneumonia being an emerging burden on Parkinson's disease patients, there is essentially nothing known on whether they are at an increased risk of pneumonia occurrence and their associated fac...

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