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Critical Care General

The Predictive Role of a Novel Risk Index in Patients Undergoing Carotid Artery Stenting: Systemic Immune-Inflammation Index.

Jul 12, 2021

Inflammatory mechanisms play an important role in both atherosclerosis and stroke. There are several inflammatory peripheral blood count markers associated with carotid artery stenosis degree, symptom...

Lethal hyperammonemia in a CAR-T cell recipient due to pneumonia: a case report of a unique severe complication.

Jul 12, 2021

We report the first incidence of infection causing lethal hyperammonemia in a chimeric receptor antigen T cell (CAR-T) recipient. A 53-year-old woman, after receiving CAR-T therapy, suffered sepsis a...

Impact of Advancing Age on the Status and Risk of Postoperative Infections After Liver Resection.

Jul 12, 2021

Despite the recently increasing number of elderly patients undergoing liver resection, the impact of advancing age on postoperative infections (PIs) incidence and risk remains unclear. This study aime...

Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment.

Jul 12, 2021

Lipocalin 2 (LCN2) is a pleiotropic molecule that is induced in the central nervous system (CNS) in several acute and chronic pathologies. The acute induction of LCN2 evolved as a beneficial process, ...

The inhibition of mammalian target of rapamycin (mTOR) in improving inflammatory response after traumatic brain injury.

Jul 12, 2021

Traumatic brain injury (TBI) provokes primary and secondary damage on endothelium and brain parenchyma, leading neurons die rapidly by necrosis. The mammalian target of rapamycin signalling pathway (m...

Epidemiology of child playground equipment-related injuries in the USA: Emergency department visits, 1995-2019.

Jul 12, 2021

To analyse the most recent trends and characteristics of playground equipment-related injuries in children.We used the National Electronic Injury Surveillance System database to acquire cases of playg...

Development and External Validation of the KIIDS-TBI Tool for Managing Children with Mild Traumatic Brain Injury and Intracranial Injuries.

Jul 12, 2021

Clinical decision support may improve the post-neuroimaging management of children with mild traumatic brain injuries (mTBI) and intracranial injuries. While the CHIIDA score has been proposed for thi...

Dilated cardiomyopathy: a new insight into the rare but common cause of heart failure.

Jul 12, 2021

Heart failure is a global health burden responsible for high morbidity and mortality with a prevalence of greater than 60 million individuals worldwide. One of the major causes of heart failure is dil...

Long non-coding RNA Pvt1 modulates the pathological cardiac hypertrophy via miR-196b-mediated OSMR regulation.

Jul 12, 2021

Cardiac hypertrophy is the uppermost risk factor for the development of heart failure, leading to irreversible cardiac structural remodeling and sudden death. As a major mediator of cardiac remodeling...

Stump appendicitis after laparoscopic appendectomy; laparoscopic management and literature review.

Jul 08, 2021

Appendectomy is one of the most common surgical procedures performed worldwide There are different etiologies for acute appendicitis such as obstruction of the appendiceal lumen by fecalith, lymphoid ...

Use of graft-derived cell-free DNA as a novel biomarker to predict allograft function after kidney transplantation.

Jul 08, 2021

To investigate the association between graft-derived cell-free DNA and pretransplantation clinical variables, and to determine whether the former could be used as a novel biomarker to predict renal fu...

New insights into lipopolysaccharide inactivation mechanisms in sepsis.

Jul 08, 2021

The complex pathophysiology of sepsis makes it a syndrome with limited therapeutic options and a high mortality rate. Gram-negative bacteria containing lipopolysaccharides (LPS) in their outer membran...

Effects of different lipid emulsions on serum adipokines, inflammatory markers and mortality in critically ill patients with sepsis: A prospective observational cohort study.

Jul 08, 2021

Intravenous lipid emulsions in parenteral nutrition may cause different metabolic responses and immune effects in critically ill patients with sepsis. The aim of this study is to investigate the effec...

Home parenteral nutrition patients on mixed oil lipid emulsion have a higher rate of hospitalizations compare to those on soybean oil- a prospective 2-year cohort study.

Jul 08, 2021

Mixed oil intravenous lipid emulsion (MO ILE) that contains 30% soybean oil (SO), 30% medium chain triglycerides, 25% olive oil and 15% fish oil can benefit hospitalized patients receiving parenteral ...

Antimicrobial coating prevents ventilator-associated pneumonia in a 72 hour large animal model.

Jul 08, 2021

The primary goal of this study was to demonstrate that endotracheal tubes coated with antimicrobial lipids plus mucolytic or antimicrobial lipids with antibiotics plus mucolytic would significantly re...

Choquet fuzzy integral-based classifier ensemble technique for COVID-19 detection.

Jul 08, 2021

The COVID-19 outbreak has resulted in a global pandemic and led to more than a million deaths to date. COVID-19 early detection is essential for its mitigation by controlling its spread from infected ...

N-acylhydrazones confer inhibitory efficacy against New Delhi metallo-β-lactamase-1.

Jul 08, 2021

The expression of β-lactamases, especially metallo-β-lactamases (MβLs) in bacteria is one of the main causes of drug resistance. In this work, an effective N-acylhydrazone scaffold as MβL inhibito...

Isolated renal mucormycosis presenting with bilateral renal artery thrombosis: a case report.

Jul 08, 2021

Mucormycosis is a rare infection caused by the fungus belonging to the order . Mucormycosis predominantly affects immunocompromised individuals such as people with acquired immunodeficiency syndrome, ...

Total hip arthroplasty for failed acetabular fracture: a double-center comparative study on failed proximal femur fracture.

Jul 08, 2021

This study aimed to compare the clinical and radiological outcomes of patients who underwent total hip arthroplasty (THA) after failed osteosynthesis of acetabular fractures vs. fractures of the proxi...

Method development and characterisation of the low-molecular-weight peptidome of human wound fluids.

Jul 08, 2021

The normal wound healing process is characterised by proteolytic events, whereas infection results in dysfunctional activations by endogenous and bacterial proteases. Peptides, downstream reporters of...

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