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Infectious Disease General

Does Postnatal Cytomegalovirus Infection Matter?

Jul 12, 2022

For a study, researchers sought to identify the postnatal cytomegalovirus (pCMV) infection features and consequences in preterm newborns in a neonatal critical care unit (NICU). A review, matched case...

Pediatric Patients Hospitalized with COVID-19: Coagulation Abnormalities and Management

Jul 12, 2022

For a study, researchers sought to provide knowledge regarding the diagnosis, treatment, and long-term effects of coagulation disorders in juvenile COVID-19 hospitalized patients. There was insufficie...

Solithromycin for Community-Acquired Bacterial Pneumonia in Children and Adolescents

Jul 12, 2022

For a study, researchers sought to assess its effectiveness and safety in kids with community-acquired bacterial pneumonia (CABP). This stage 2/3, randomized, open-mark, dynamic control, multicenter c...

Spondylodiscitis in Children: A Retrospective Cohort Study

Jul 12, 2022

For a study, researchers sought to direct 29 kids with spondylodiscitis. Clinical, hematic, and radiologic information was gathered and thought about between 2 age subgroups (beneath and from 4 years ...

A Single-Center Experience with Pediatric Musculoskeletal Coccidioidomycosis in Central California

Jul 11, 2022

For a study, researchers sought to understand that the clinical appearance, diagnosis, medicinal and surgical therapy, and results of pediatric musculoskeletal coccidioidomycosis at a tertiary care ho...

Early Delivery of Tocilizumab in COVID-19 Patients Hospitalized With Increased Inflammatory Markers

Jun 23, 2022

Severe COVID-19 was connected with an immune response imbalance. Researchers expected that interleukin-6 blocking would be beneficial for patients with increased inflammation, as indicated by elevated...

Toxoplasma Gondii: Infection & Aggression in Autistic Children

May 31, 2022

Toxoplasmosis was an infectious disease caused by Toxoplasma gondii, an obligate intracellular parasite. For a study, researchers sought a link between T. gondii infection and aggression in autistic c...

COVID-19 Lockdown & Epidemiology of Neonatal Sepsis

May 31, 2022

In a level 3 neonatal unit, this retrospective cohort research was done. Group LD: 22 March 2020 to 5 September 2020—the reference group, Group pre-LD: 29 September 2019 to 14 March 2020, and Group ...

Distinct Antibiotic Regimens in Pediatric Appendectomies

May 31, 2022

The lack of comprehensive studies on microbiologic data and susceptibility patterns explained the lack of a uniform treatment protocol. A retrospective, monocentric study on antibiotic susceptibility ...

Late-Onset GBS Bacteremia: Pediatric ED & Infection

May 31, 2022

A multicenter prospective registry observational research and subanalysis. The scene: a pediatric emergency room. Infants aged 7 to 89 days with positive blood culture for GBS between 2011 and 2016 at...

Nitroxoline Activity in Antifungal-Resistant Candida Species Isolated from the Urinary Tract in Vitro

May 26, 2022

Drug-resistant fungus infections were becoming more common worldwide, yet only a few new antifungals were being produced. The ancient antibacterial nitroxoline was used to treat bacterial urinary trac...

Impact of Clopidogrel on Clinical Outcomes in Staphylococcus Aureus Bacteremia Patients

May 26, 2022

Antimicrobial action of activated platelets against Staphylococcus aureus was known. Thrombocytopenia and higher patient mortality could be caused by S. aureus-induced platelet clearance. In a large n...

Pharmacokinetics & Dose Optimization Strategies of Para-Aminosalicylic Acid in RR-TB Children

May 26, 2022

Rifampicin-resistant tuberculosis (RR-TB) therapy choices for children were limited, and para-aminosalicylic acid (PAS) remained an important component of treatment regimens. PAS's ability to prevent ...

Heavily Treatment-Experienced Adults Living with Multidrug-Resistant HIV-1: Genotypic & Phenotypic Results

May 26, 2022

In phase 3 BRIGHTE research, fostemsavir plus optimal background therapy (OBT) resulted in sustained rates of virologic suppression for 96 weeks in highly treated persons with multidrug-resistant HIV-...

Enterococcus faecium in Response to a Combination of Daptomycin & Fosfomycin Reveals Adaptive Strategies

May 26, 2022

Vancomycin-resistant Enterococcus faecium (VREfm) infections were a major public health concern. The front-line antibiotic daptomycin (DAP) had become increasingly resistant to VREfm isolates. As a re...

Antiviral Activity of Remdesivir & GS-441524 Against Delta, Omicron, & Other SARS-CoV-2 Variants

May 26, 2022

Multiple variations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had emerged and spread rapidly across the pandemic, with Omicron being the most prevalent version now circulatin...

Common & Rare Genetic Markers of SLIDs Resistance in Mycobacterium Tuberculosis

May 26, 2022

Resistance to the second-line injectable medicines (SLIDs) amikacin (AMK), capreomycin (CAP), and kanamycin (KAN) was known to be conferred by point mutations in the rrs gene and the eis promoter. Whi...

Safety of iABLC as Antifungal Prophylaxis in Lung Transplant Recipients

May 26, 2022

The most extensively used antifungal preventive medicines in lung transplant recipients have inhaled forms of amphotericin B, but there was minimal data on their safety. Researchers conducted a single...

The Effect of Rifampicin on Darunavir, Ritonavir, & DTG Exposure Within PBMCs

May 26, 2022

The induction of metabolizing enzymes and efflux transporters mediated by rifampicin (Rif) affected ritonavir-boosted darunavir (DRV/r) and dolutegravir (DTG). It affected the treatment of tuberculosi...

Unbound Ceftriaxone in Critically Ill Patients: A Multicenter Population Pharmacokinetic Study

May 26, 2022

For a study, researchers sought to determine optimal dosing regimens by describing the total and unbound population pharmacokinetics of ceftriaxone in critically ill adult patients. About 2  pharmaco...