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Opioids

Harms Vs Benefits of Opioid Prescription Changes in HIV

Jun 17, 2022

Providers should not continue prescribing opioids to patients with HIV when risks outweigh benefits, but they need to factor the risks of stopping opioids into the equation. “There are specif...

From the Physician Editor-in-Chief - Chronic Pain: We Need to Ask “Why?”

May 31, 2022

According to the CDC, there are approximately 50 million people in the US living in chronic pain. We all know about the opioid crisis, and this knowledge has done nothing to help alleviate pain many a...

Impact of Enhanced Recovery Implementation in Women Undergoing Abdominal Sacrocolpopexy.

May 23, 2022

Assess the effect of Enhanced Recovery After Surgery with and without liposomal bupivacaine (LB) on opioid use, hospital length of stay (LOS), costs, and morbidity of women undergoing sacrocolpopexy.R...

Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit.

May 23, 2022

In perilous and stressful situations, the ability to suppress pain can be critical for survival. The rostral ventromedial medulla (RVM) contains neurons that robustly inhibit nociception at the level ...

Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling.

May 16, 2022

Opioid and beta-adrenergic receptors are recently shown to cross talk via formation of receptor heterodimers to control the growth and proliferation of breast cancer cells. However, the underlying cel...

Developing a novel treatment for patients with chronic pain and Opioid User Disorder.

May 09, 2022

It is critical to develop empirically based, community-treatment friendly, psychotherapy interventions to improve treatment for patients with comorbid chronic pain and Opioid Use Disorder. Understandi...

Becoming our young people's case managers: caregivers' experiences, needs, and ideas for improving opioid use treatments for young people using opioids.

May 09, 2022

Evidence continues to show that young people, ages 15-24, remain at significant risk of harms from non-medical opioid use and opioid use disorder (OUD), with experts calling for widespread implementat...

Risk Factors Associated with Perinatal Relapse to Opioid Use Disorder.

May 02, 2022

The recent opioid epidemic in the United States has led to rising prevalence of maternal opioid use disorder (OUD). First-line treatment for maternal OUD involves the use of opioid agonist pharmacothe...

Young adult opioid misuse indicates a general tendency toward substance use and is strongly predicted by general substance use risk.

Apr 25, 2022

To examine whether young adult opioid misuse reflects a general tendency toward substance use and is influenced by general substance use risk or whether it is a different phenomenon from other drug us...

The introduction of fentanyl on the US-Mexico border: An ethnographic account triangulated with drug checking data from Tijuana.

Apr 18, 2022

Illicitly-manufactured fentanyls (fentanyl) have changed the risk environment of people who use drugs (PWUD). In California and many western US states, the opioid overdose rate spiked from 2016 to 202...

Pain management with popliteal block for fibular graft harvesting in head and neck reconstruction; a randomised double-blind placebo-controlled study.

Apr 18, 2022

Curative treatment for locally advanced head and neck tumours often includes reconstructive surgery using a microvascular free flap. Effective recuperation is essential but may be impeded by postopera...

Opioid administration trends among long-stay community living centers residents with dementia.

Apr 11, 2022

Pain assessment and management of Veterans with Alzheimer's disease and Related Dementia (ADRD) living in Community Living Centers (CLCs) is challenging. Safe and effective use of opioids in the treat...

Understanding the role of urban social and physical environment in opioid overdose events using found geospatial data.

Apr 04, 2022

Opioid use disorder is a serious public health crisis in the United States. Manifestations such as opioid overdose events (OOEs) vary within and across communities and there is growing evidence that t...

Elective choledochal cyst excision is associated with improved postoperative outcomes in children.

Mar 28, 2022

The majority of pediatric patients with choledochal cysts (CDC) are symptomatic prior to undergoing CDC excision. This study investigated the impact of surgical timing of CDC excision on postoperative...

Evaluating Outcomes and Misuse in Opioid-Dependent Chronic Pancreatitis Using a State-Mandated Monitoring System.

Mar 21, 2022

Patients with chronic pancreatitis (CP) often require opioids for pain control. The goal of our study was to characterize opioid use in patients with CP in a real-life practice using a state-mandated ...

Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre.

Mar 21, 2022

Strict adherence to pharmacological dosage regimens is a prerequisite to the success of most treatments, particularly for patients in drug abuse programs. The compliance of tramadol, an atypical non-s...

Impacts of a Medicaid "lock-in" program on opioid use disorder treatment and services and naloxone dispensing.

Mar 14, 2022

"Lock-in" programs are used by health insurers to reduce the risk of adverse outcomes that can result from overutilization of opioids and other controlled substances. We estimated the association betw...

Fos response of the tail of the ventral tegmental area to food restriction entails a prediction error processing.

Mar 07, 2022

The tail of the ventral tegmental area (tVTA) or rostromedial tegmental nucleus (RMTg) receives lateral habenula inputs and projects heavily to midbrain dopamine neurons. Midbrain dopamine and lateral...

Gaps in hepatitis C virus prevention and care for HIV-hepatitis C virus co-infected people who inject drugs in Canada.

Feb 28, 2022

People who inject drugs (PWID) living with HIV are a priority population for eliminating hepatitis C virus (HCV) as a public health threat. Maximizing access to HCV prevention and treatment strategies...

Opioid Use after Nephrectomy for Kidney Cancer in Ontario: A Population-Based Study.

Feb 21, 2022

To compare the odds of early and prolonged post-operative opioid use in patients undergoing minimally invasive surgery (MIS) versus open surgery for nephrectomy.For opioid-naïve patients in Ontario w...