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Comparison of Enzian and rASRM classifications in predicting symptoms of sexual dysfunction in endometriosis.

May 12, 2025

Endometriosis is known to negatively impact sexual function; however, limited research has explored whether classification systems can help pinpoint specific anatomical locations associated with sexual dysfunction. This study...

Survival outcomes after pathologic complete response with neoadjuvant endocrine therapy vs. neoadjuvant chemotherapy: a retrospective national database study.

May 12, 2025

Neoadjuvant therapies can result in pathologic complete response (pCR) in patients with breast cancer, which can be predictive of long-term outcomes. Patients with estrogen receptor positive (ER +) tumors may receive either...

Changes of Aortic Elastic Properties in Normal Fetuses During the Second Half of Pregnancy.

May 5, 2025

The purpose of the study was to observe the elastic properties of the aorta in normal fetuses by M-mode echocardiography.This was a prospective cross-sectional study performed in 402 normal fetuses during 20-37 weeks of...

Exosomal miR-122-5p for regulation of secretory functions of fibroblasts and promotion of breast cancer metastasis by targeting MKP-2: an experimental study.

May 5, 2025

Tumor metastasis is a major obstacle for the effective treatment of breast cancer. Some studies showed that exosomes could promote tumor distant metastasis by establishing pre-metastasis niches (PMN). MicroRNAs (miRNAs) in...

Intratumoral and peritumoral radiomics signature based on DCE-MRI can distinguish between luminal and non-luminal breast cancer molecular subtypes.

Apr 28, 2025

Distinguishing the luminal subtypes of breast cancer (BC) remaining challenging. Thus, the aim of this study was to investigate the feasibility of radiomic signature using intratumoral and peritumoral features obtained from...

GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway.

Apr 28, 2025

Brain metastasis is emerging as the most serious concern for breast cancer patients. HER2-positive breast cancer is more prone to undergo brain metastasis than other subtypes; notably, there has been little improvement in the...

Foundation model-driven multimodal prognostic prediction in patients undergoing primary surgery for high-grade serous ovarian cancer.

Apr 21, 2025

High-grade serous ovarian cancer (HGSOC) presents challenges in prognostic prediction. This study aimed to develop a universal foundation model-driven multimodal model (FoMu model) to assess the prognosis of HGSOC patients. We...

Green Synthesis of Pyrazole Linked Thiazole Derivatives with Enhanced Anti-Breast Cancer Activity: WEB-Mediated Protocol, Anticancer Screening, EGFR Inhibition, In Silico ADME and DFT Calculations.

Apr 21, 2025

The current research investigates the green and efficient water extract of banana peel (WEB) mediated synthesis of thiazole derivatives and their anticancer activity against the MCF-7 breast cancer cell line. A total ten novel...

A Bayesian quantile regression approach for determining risk factors of low birth weight of under five children in Cambodia.

Apr 14, 2025

Birth weight (BW) is a key indicator of a newborn’s health, survival, and development. It is associated with the risk of childhood mortality and is also related to health, physical growth, emotional well-being, and...

Cost-utility analysis of olaparib assisted targeted therapy for BRCA mutation HER2-negative early breast cancer in China and in the United States.

Apr 14, 2025

Olaparib, an inhibitor of poly (ADP-ribose) polymerase (PARP), has demonstrated promising outcomes in treating HER2-negative early-stage breast cancer with BRCA mutations. However, a comprehensive evaluation of its...

ATF6α inhibits ΔNp63α expression to promote breast cancer metastasis by the GRP78-AKT1-FOXO3a signaling.

Apr 14, 2025

Endoplasmic reticulum (ER) stress is increasingly recognized as a driver of cancer progression; however, the precise molecular mechanisms by which ER stress facilitates tumor metastasis remain incompletely understood. In this...

Development of radiomics-based models on mammograms with mass lesions to predict prognostically relevant characteristics of invasive breast cancer in a screening cohort.

Apr 7, 2025

Optimizing breast-screening performance involves minimizing overdiagnosis of prognostically favorable invasive breast cancer (IBC) that does not need immediate recall and underdiagnosis of prognostically unfavorable IBC that is...

Screening Positive for Rare Autosomal Aneuploidies Increases Frequency of Adverse Pregnancy Outcomes and Alters Clinical Management.

Mar 24, 2025

Outcomes in pregnancies with rare autosomal aneuploidies (RAAs) are poorly characterized, with most studies having small sample sizes. Here, we describe outcomes and management in a large cohort of pregnancies that screened...

The Translation of Policy to Person: A Qualitative Analysis of Elite Athletes’ Perceptions of Pregnancy in the United Kingdom.

Mar 17, 2025

An increasing number of female athletes are navigating an athletic career alongside pregnancy. Limited qualitative research has investigated the experiences of elite athletes in the United Kingdom (UK). This study aimed to...

Potential Adverse Events of Fluoxetine: A Real-world Study Based on FAERS Database.

Mar 17, 2025

This study aimed to mine and analyze adverse event signals of fluoxetine using the FAERS database.This study focused on suspected drug adverse reaction reports from the first quarter of 2004 to the second quarter of 2023, with...

ESM1 suppresses LncRNA GAS5/miR-23a-3p/PTEN axis to promote the cisplatin-chemotherapy resistance of ovarian cancer cells via activating the PI3K/AKT pathway.

Mar 17, 2025

Cisplatin chemotherapy is an important treatment for advanced ovarian cancer (OC). However, the development of cisplatin resistance greatly limits the survival time of OC patients. Endothelial cell-specific molecule 1 (ESM1) has...

Next-generation sequencing based deep learning model for prediction of HER2 status and response to HER2-targeted neoadjuvant chemotherapy.

Feb 10, 2025

For patients with breast cancer, the amplification of Human Epidermal Growth Factor 2 (HER2) is closely related to their prognosis and treatment decisions. This study aimed to further improve the accuracy and efficiency of HER2...

Exposure of pregnant and lactating parental mice to aflatoxin B promotes hepatotoxicity in offspring mice.

Feb 3, 2025

Aflatoxin B1 (AFB) taints feeds stuffs, endangering livestock’s health and resulting in the liver and breast damage. At the same time, while breastfeeding, AFB crosses the mammary glands and enters the milk, harming the...

SHP2 regulates the HIF-1 signaling pathway in the decidual human endometrial stromal cells.

Feb 3, 2025

The decidual endometrial stromal cells play a critical role in the establishment of uterine receptivity and pregnancy in human. Our previous studies demonstrate that protein tyrosine phosphatase 2 SHP2 is highly expressed in...

The impact of breast surgery and systemic therapy on the survival of patients with de novo stage IV breast cancer.

Feb 3, 2025

Systemic therapy (ST) is essential for de novo stage IV breast cancer (BC). Stage IV BCs are highly heterogeneous, and it seems inappropriate to treat all de novo stage IV BCs equally. The survival benefit of surgery for primary...

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