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OB/GYN General

Primary Ovarian Insufficiency in women with Addison's disease.

Mar 11, 2021

Primary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison's disease (AAD) than in the general population, but the...

The Effect of Leptin Receptor Gene Polymorphisms (R223Q and P1019P) in Susceptibility to Polycystic Ovarian Syndrome in Kurdish Women.

Mar 11, 2021

Polycystic ovary syndrome (PCOS) is the known endocrinopathy disorder in the reproductive phase of women's life. More than half of the women with PCOS suffer from obesity which impacts the ovarian fun...

A highly sensitive electrochemical microRNA-21 biosensor based on intercalating methylene blue signal amplification and a highly dispersed gold nanoparticles/graphene/polypyrrole composite.

Mar 11, 2021

Numerous clinical studies suggest that microRNAs (miRNAs) are indicative biomolecules for the early diagnosis of cancer. This work aims to develop a cost-effective and label-free electrochemical biose...

Role of dietary fat on obesity-related postmenopausal breast cancer: insights from mouse models and methodological considerations.

Mar 11, 2021

The increasing incidence rate of breast cancer in the last few decades is known to be linked to the upward trend of obesity prevalence worldwide. The consumption of high-fat diet in particular has bee...

A Newly Characterized Potentially Probiotic Strain, Lactobacillus brevis MK05, and the Toxicity Effects of its Secretory Proteins Against MCF-7 Breast Cancer Cells.

Mar 11, 2021

Among seven strains of lactic acid bacteria (LAB) isolated from traditional dairy products, a Lactobacillus strain was identified through 16S rRNA gene sequencing and tentatively designated as Lactob...

Placebo Response in Patients with Oral Therapy for Overactive Bladder: A Systematic Review and Meta-analysis.

Mar 08, 2021

The role of a placebo response in the management of overactive bladder (OAB) remains unclear.The aim of this review is to methodically study the placebo response extracted from the control arms of ran...

Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β-adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity.

Mar 08, 2021

Transient receptor potential melastatin 8 (TRPM8) channels may contribute to the pathophysiological bladder afferent hyperactivity, thus a TRPM8 antagonist would be a promising therapeutic target for ...

Biodegradable materials for surgical management of stress urinary incontinence: A narrative review.

Mar 08, 2021

Stress urinary incontinence (SUI) was managed with techniques such as colposuspension, autologous fascia sling and urethral bulking agents. The introduction of the mid-urethral polypropylene (PP) slin...

Hemoperitoneum during removal of the placenta in advanced abdominal pregnancy with live fetus delivered at 37 weeks of gestation. A case report in a low-resource setting and literature review.

Mar 08, 2021

Advanced abdominal pregnancy (> 20 weeks gestation) is a rare condition life-threatening for mother and fetus.A 31-years-old African woman presented from a rural district to Mutoyi Hospital for fir...

Predicting the change in perinatal disordered eating symptoms: An examination of psychosocial factors.

Mar 08, 2021

Disordered eating symptoms remain a largely unidentified and unsupported area in perinatal healthcare, particularly as they pertain to women without diagnosed eating disorders. In an Australian prospe...

The impact of porcine reproductive and respiratory syndrome virus (PRRSV) genotypes, established on the basis of ORF-5 nucleotide sequences, on three production parameters in Ontario sow farms.

Mar 08, 2021

The porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped RNA virus, with high mutation rates and genetic variability; which is evident by the large number of discrete strains th...

Biological significance of KRAS mutant allele expression in ovarian endometriosis.

Mar 08, 2021

KRAS is the most frequently mutated in ovarian endometriosis. However, it is unclear whether the KRAS mutant allele's mRNA is expressed and plays a biological role in ovarian endometriosis. Here, we p...

Identification of immune microenvironment subtypes that predicted the prognosis of patients with ovarian cancer.

Mar 08, 2021

Ovarian cancer (OC) is associated with high mortality rate. However, the correlation between immune microenvironment and prognosis of OC remains unclear. This study aimed to explore prognostic signifi...

Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer.

Mar 08, 2021

Ovarian cancer is the seventh most common cancer in women worldwide and the eighth most common cause of cancer death. Due to the lack of effective early detection strategies and the unspecific onset o...

Urogenital atrophy: The 'unknown factors' challenging current practice.

Mar 08, 2021

Urogenital atrophy occurs as a result of the effect of estrogen deficiency on the tissue quality in the vulva, vagina, urethra and bladder. It is a common consequence of the menopause, with possibly u...

Widespread Pain Hypersensitivity and Lumbopelvic Impairments in Women Diagnosed with Endometriosis.

Mar 08, 2021

To explore hypersensitivity to pain and musculoskeletal impairments in the lumbopelvic area in women with and without endometriosis.This cross-sectional study included 66 women (41 women with endometr...

S100A7 promotes the development of human endometriosis by activating NF-κB signaling pathway in endometrial stromal cells.

Mar 08, 2021

Endometriosis (EM) is a chronic inflammatory disease affecting women between ages of 23-42 years with a prevalence of 6% to 10%. S100A7, a member of the S100 protein family, has been implicated in p...

"The use of bisphosphonates to treat skeletal complications in solid tumours".

Mar 08, 2021

The skeleton is the most common site of secondary disease in breast cancer and prostate cancer, with up to 80% of patients with advanced disease developing bone metastases (BM). The proportion is also...

Identification of U83836E as a γ-glutamylcyclotransferase inhibitor that suppresses MCF7 breast cancer xenograft growth.

Mar 08, 2021

γ-Glutamylcyclotransferase (GGCT) is involved in glutathione homeostasis, in which it catalyzes the reaction that generates 5-oxoproline and free amino acids from γ-glutamyl peptides. Increasing evi...

Plasmodium infection inhibits triple negative 4T1 breast cancer potentially through induction of CD8 T cell-mediated antitumor responses in mice.

Mar 08, 2021

We previously reported that Plasmodium infection promotes antitumor immunity in a murine Lewis lung cancer. In this study, we investigated the effects of Plasmodium infection on the tumor inhibition a...

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