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Compliance with international guidelines in adults with encephalitis.

Apr 22, 2020

Encephalitis is associated with significant neurological disability and mortality. Many guidelines are published for encephalitis management but compliance with them is unknown.To evaluate the appropr...

Improving immunogenicity and safety of flagellin as vaccine carrier by high-density display on virus-like particle surface.

Apr 22, 2020

Flagellin is a protein-based adjuvant that activates toll-like receptor (TLR) 5. Flagellin has been actively explored as vaccine adjuvants and carriers. Preclinical and clinical studies find flagellin...

Trichomonas vaginalis in Pregnancy: Patterns and Predictors of Testing, Infection, and Treatment.

Apr 14, 2020

To identify factors associated with testing for and diagnosis of trichomoniasis in pregnancy and to describe patterns of treatment and tests of reinfection or persistence.We conducted a retrospective ...

The balancing perspective of hard-to-reach hepatitis C patients who were lost to follow-up: A qualitative study.

Apr 14, 2020

In the foreseeable future, patients with hepatitis C virus (HCV) with good healthcare access will all have been cured and the lost to follow-up (LFU) HCV-population will increasingly exist of hard-to-...

Clinical characteristics and immunosuppressants management of coronavirus disease 2019 in solid organ transplant recipients.

Apr 14, 2020

Over 1,000,000 cases of coronavirus disease 2019 (COVID-19) have been confirmed since the worldwide outbreak began. Not enough data on infected solid organ transplant (SOT) recipients are available, e...

Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity.

Apr 14, 2020

In individuals with mitochondrial disease, respiratory viral infection can result in metabolic decompensation with mitochondrial hepatopathy. Here, we used a mouse model of liver-specific Complex IV d...

The increased virulence of hypervirulent fowl adenovirus 4 is independent of fiber-1 and penton.

Apr 14, 2020

Hepatitis-hydropericardium syndrome (HHS) caused by hypervirulent fowl adenovirus 4 (FAdV-4) have been causing great economic losses to Chinese poultry industry since 2015. Elucidation of the pathogen...

HPV may not play a role in all lacrimal transitional cell papilloma.

Apr 07, 2020

Tumours of the lacrimal duct apparatus (LDA) are rare and heterogenous but knowledge of their aetiology is important for the rhinologist. A link between transitional cell papilloma/carcinoma (TCP/TCC)...

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.

Apr 07, 2020

In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual s...

Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-B pathway.

Apr 07, 2020

Loratadine is an antihistamine drug that shows promise as an anti-inflammatory drug, but supportive studies are lacking. We elucidated the effects and mechanisms by which loratadine inhibits inflammat...

Hepatitis E: an expanding epidemic with a range of complications.

Apr 07, 2020

Hepatitis E virus (HEV) is a common cause of viral hepatitis worldwide. Previously considered a disease of the developing world, it is increasingly recognised that locally acquired HEV infection is co...

The farnesyltransferase inhibitor tipifarnib protects against autoimmune hepatitis induced by Concanavalin A.

Apr 07, 2020

No effective treatment has been established for autoimmune hepatitis (AIH), except for liver transplantation in the fatal stage. Little is known about the roles and mechanisms of farnesyltransferase i...

In situ hybridization revealed wide distribution of Haliotid herpesvirus 1 in infected small abalone, Haliotis diversicolor supertexta.

Mar 23, 2020

Ganglioneuritis was the primary pathologic change in infected abalone associated with Haliotid herpesvirus 1 (HaHV-1) infection, which eventually became known as abalone viral ganglioneuritis (AVG). H...

HEV infection in an Italian cohort of HSCT recipients: seroprevalence and infection.

Mar 23, 2020

Chronic hepatitis E virus (HEV) infection in hematopoietic stem cell transplant (HSCT) recipients is an emerging threat. The aim of this study was to provide data on HEV burden in an Italian cohort of...

High hepatitis B virus screening rate among patients receiving systemic anticancer treatment in Japan.

Mar 23, 2020

Patients with hepatitis B virus (HBV) infection have a risk of reactivation after chemotherapy. All patients undergoing chemotherapy should be screened for HBV infection. No large-scale studies have b...

CME: A Call to Action to Increase HPV Awareness & Vaccination Rates

Mar 20, 2020

This course discusses the findings of questions on human papillomavirus knowledge from a cross-sectional analysis of the Health Information National Trend Survey....

Measuring hepatitis C virus elimination as a public health threat:beyond global targets.

Mar 19, 2020

An increasing number of countries are committing to meet the World Health Organization (WHO) targets to eliminate hepatitis C virus (HCV) as a public health threat by 2030. These include service cover...

Psychological interventions for people with hemophilia.

Mar 19, 2020

Managing hemophilia is challenging both in terms of medical treatment and its broad impact on many aspects of the individual's life, including self-perception. Several psychosocial issues are potentia...

Prevalence, clinical course, and predictive factors of immune checkpoint inhibitor monotherapy-associated hepatitis in Japan.

Mar 19, 2020

Immune checkpoint inhibitors (ICI) have revolutionized anti-malignancy therapy and thus have been increasingly used. Although ICI may cause immune-related adverse events (irAE) in various organs, incl...

Alanine Aminotransferase Influencing Performances of Routine Available Tests Detecting Hepatitis B Related Cirrhosis.

Mar 19, 2020

The performances of routine tests such as FIB-4 and APRI in detecting cirrhosis and significant fibrosis in chronic hepatitis B (CHB) have been shown to be discrepant between studies.Novel testssuch a...