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Oncology / Hematology

Development of Combination Therapies for Biliary Tract Cancers: A Rational Approach

Nov 21, 2022

A rare group of gastrointestinal malignancies with a significant morbidity and death rate are biliary tract tumors. Most patients arrive with a locally progressed or metastatic illness that is incurab...

Reverse Inflammaging: The long-term Impact of HCV Treatment on Biological Aging

Nov 21, 2022

Direct-acting antivirals (DAAs) are effective in treating chronic hepatitis C virus (HCV) infections. However, not all chronic hepatitis C complications seem to be fully curable following a sustained ...

Variants Effect in LGP2 on MDA5-mediated Activation on Hepatitis D Virus Replication

Nov 21, 2022

Retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated protein 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2) are RIG-I-like receptors (RLRs), which detect viral RNA...

Analysis of Dynamic Phospho-profiling in Human Early Erythropoiesis

Nov 21, 2022

The careful control of protein expression and phosphorylation modification is essential for normal early erythropoiesis. Erythroid diseases are influenced by dysregulation of protein synthesis or modi...

Analysis of Human Leukocyte Antigen Mismatch on Unrelated Bone Marrow Transplantation in Pediatric Patients

Nov 21, 2022

It had not been well investigated how unrelated bone marrow transplantation affected pediatric patients with hematological malignancies when there is human leukocyte antigen (HLA) mismatching at the H...

Diagnosing Nodular Lymphocyte-predominant Hodgkin Lymphoma in Tumor Cell

Nov 21, 2022

While analyses were still lacking for nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), several research had defined the microenvironment and its predictive influence in classic Hodgkin lymphom...

FDA: Patients Should Be Cautious When Using Online Pharmacies to Buy Meds

Nov 19, 2022

FRIDAY, Nov. 18, 2022 (HealthDay News) -- The U.S. Food and Drug Administration is warning consumers to be careful when buying prescription medication online. While some pharmacy websites operate lega...

Daily low dose aspirin may be associated with increased fall risk for geriatric patients

Nov 18, 2022

1. For healthy elderly patients randomized to take low-dose aspirin for 4 weeks, there was no difference in occurrence of fractures, but a higher occurrence of serious falls prompting hospitalization,...

Downregulation of YAP Activity Through LCK Inhibition in Cholangiocarcinoma

Nov 18, 2022

The development of new, efficient medicinal treatments for cholangiocarcinoma (CCA) was an unmet need. YAP, an effector in the Hippo pathway that causes cancer in CCA, had previously been challenging ...

Incidence of Primary Liver Cancer Worldwide in 2020 and Predictions to 2040

Nov 18, 2022

The impact of liver cancer differs globally. For a study, researchers sought to report updated estimates of the incidence and mortality of liver cancer worldwide as well as projections of the disease'...

Homologous Recombination and Hereditary Cancer Variants in Biliary Tract Cancer

Nov 18, 2022

It was unclear if molecular therapy for biliary tract cancer (BTC) was heritable and practicable. Homologous recombination deficit had not been researched in BTCs, despite the description of links bet...

Artificial Intelligence-Aided Colonoscopy Does Not Increase Cancer Detection

Nov 18, 2022

THURSDAY, Nov. 17, 2022 (HealthDay News) -- Adenoma and polyp detection rates (ADR/PDR) are lower with use of artificial intelligence-aided colonoscopy (AIAC), according to a study published in the No...

Apixaban is associated with a lower risk of gastrointestinal bleeding than other direct oral anticoagulants

Nov 17, 2022

1. In this population-based cohort study, apixaban was associated with a lower risk of gastrointestinal bleeding (GIB) as compared to dabigatran, edoxaban, or rivaroxaban. 2. Apixaban was associated w...

#VisualAbstract: Second-line immunosuppression associated with worse outcomes for immune-related adverse events in melanoma

Nov 17, 2022

1. Median overall survival was longer in patients receiving steroid-only treatment for adverse events associated with immune response. 2. Patients receiving steroids plus any immunosuppressant for ...

Gilteritinib Plus Azacitidine Vs. AZA Diagnosed FLT3mut+ AML Ineligible for Intensive Chemotherapy

Nov 17, 2022

The outcomes of treatment for people with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-mutated (FLT3mut+) acute myeloid leukemia (AML) who were not candidates for intense chemotherapy were unsati...

Survival Improvement with Ibrutinib in MCL With Central Nervous System Relapse

Nov 17, 2022

Mantle cell lymphoma (MCL) recurrence in the central nervous system (CNS) is an uncommon occurrence with a poor prognosis and no approved treatment. For a study, researchers conducted a multicenter re...

Comparable outcomes amongst three different types of drug-eluting stents in BIO-RESORT Trial

Nov 16, 2022

1. At 5 years follow-up, rates of target vessel failure were comparable amongst 3 types of drug-eluting stents (DES), in all-comers and patients with diabetes, including Orsiro sirolimus (SES), Synerg...

Rare Germline ATM VUS in Chronic Lymphocytic Leukemia (CLL) and Other Cancers

Nov 16, 2022

Genetic testing revealed a huge number of ATM (ataxia-telangiectasia mutated) variants of uncertain significance (VUS), despite the fact that germline pathogenic ATM (ataxia-telangiectasia mutated) va...

Newly Diagnosed Multiple Myeloma Patients with Daratumumab Plus RVD

Nov 16, 2022

Multiple myeloma patients have a higher risk of vascular thromboembolic events (VTEs). For a post hoc analysis, researchers assessed VTEs in phase 2 randomized GRIFFIN trial, which examined lenalidomi...

Combined Immunosuppression for AHA: High Efficacy of CyDRi with Low Toxicity Regimen

Nov 16, 2022

The rare severe autoimmune bleeding illness known as acquired hemophilia A (AHA) has a high morbidity and fatality rate. Despite its importance in disease management, there is no agreement on the idea...