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Ophthalmology General

Elucidation of Pathophysiology and Novel Treatment for Diabetic Macular Edema Derived from the Concept of Neurovascular Unit.

Nov 09, 2020

The retina transmits light signals to the brain via a complex structure composed of photoreceptor cells, neurons including ganglion cells, glial cells such as astrocytes and Mueller cells, as well as ...

miR-200-3p suppresses cell proliferation and reduces apoptosis in diabetic retinopathy via blocking the TGF-β2/Smad pathway.

Nov 09, 2020

Increasing evidence has shown that microRNAs (miRNAs) play an important role in the pathogenesis of diabetic retinopathy (DR). However, the role and mechanism of miRNA in regulating high glucose (HG)-...

Normal vitreous promotes angiogenesis via activation of Axl.

Nov 09, 2020

Vitreous has been reported to prevent tumor angiogenesis, but our previous findings indicate that vitreous activate the signaling pathway of phosphoinositide 3-kinase (PI3K)/Akt, which plays a critica...

G-protein-coupled estrogen receptor protects retinal ganglion cells via inhibiting endoplasmic reticulum stress under hyperoxia.

Nov 09, 2020

Abnormal development of immature retinal vascular structure in preterm infants under the condition of hyperoxia is the primary cause of retinopathy of prematurity (ROP), which has become the leading c...

Brinzolamide loaded core-shell nanoparticles for enhanced coronial penetration in the treatment of glaucoma.

Nov 09, 2020

A neurodegenerative disorder, glaucoma is a leading cause of blindness in the world. The conventional treatment strategies do not allow the significant penetration of the drug in the cornea. Therefore...

Preliminary evaluations of 3-dimensional human skin models for their ability to facilitate in vitro the long-term development of the debilitating obligatory human parasite Onchocerca volvulus.

Nov 09, 2020

Onchocerciasis also known as river blindness is a neglected tropical disease and the world's second-leading infectious cause of blindness in humans; it is caused by Onchocerca volvulus. Current treatm...

Efficiency of Operating Room Processes for Elective Cataract Surgeries Done by Residents in a National University Hospital.

Nov 09, 2020

Operating room processes must be efficient to boost profitability and minimize cost while retaining surgical care quality. This study aims to assess operating room efficiency for resident-performed el...

Influence of Perfluorocarbon Liquids on Peripapillary Retinal Nerve Fiber-Layer Thickness Following Pars Plana Vitrectomy with Silicone Oil-Based Endotamponade.

Nov 09, 2020

Inner retina-layer modifications after pars plana vitrectomy (PPV) can be objectively assessed through spectral domain optical coherence tomography (SD-OCT).This study explored prospectively changes i...

What can anisometropia tell us about eye growth?

Nov 07, 2020

The study explored the interocular differences in biometry to determine the potential role of other factors in refractive development. In 362 subjects Childhood Errors of Refraction study were studie...

Can we eradicate trachoma? A survey of stakeholders

Nov 06, 2020

Although tremendous progress towards the 2020 goal of global elimination of trachoma as a public health problem has been made, it will not be achieved. Future targets are now being considered. One opt...

Survival of the fittest: phacoemulsification outcomes in four corneal transplants by Dr Ramon Castroviejo

Nov 06, 2020

The study was done to check the outcomes following phacoemulsification on four eyes, 45 years or more after corneal transplantation to get excellent long-term results. A retrospective case series of ...

Prevalence and risk factors of pseudomyopia in a Chinese children population

Nov 06, 2020

The study was done to investigate the prevalence and predictors of pseudomyopia in Chinese children and its association with myopia progression. 2612 children aged 6 years and 1984 children aged 13 y...

Impact of anxiety and depression on progression to glaucoma among glaucoma suspects

Nov 06, 2020

The study was done to assess the impact of anxiety and depression in the risk of converting to glaucoma in a cohort of glaucoma suspects followed over time. The study included a retrospective cohort ...

Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy

Nov 06, 2020

The study was done to characterise the pRNFL thickness changes in patients with LHON having m.11778G>A (MT-ND4) mutation. This retrospective cross-sectional study included 221 eyes from patients w...

Testing Visual Acuity Via Telemedicine

Nov 05, 2020

“Telemedicine has been brought to the forefront of everyone’s practice during the COVID-19 pandemic,” says Evan Silverstein, MD. “Some specialties are well-suited for telemedicine, while other...

Twenty years of International Council of Ophthalmology fellowships: description of the programme and the impact on more than 1100 awardees

Nov 05, 2020

The objective of the present study was to evaluate how the ICO Fellowship Programme has impacted on improving knowledge, skills and the careers of young ophthalmologists from low-resource countries. ...

Nationwide trends in the incidence of orbital lymphoma from 1999 to 2016 in South Korea

Nov 05, 2020

This study was done to provide a population-based report on the epidemiology of orbital lymphomas and measure the trends in the incidence of orbital lymphoma cancer in South Korea. 630 patients with ...

Rates of spondyloarthropathies vary with age and ethnicity in HLAB27 uveitis

Nov 05, 2020

This study aims to determine associations between HLAB27-positive uveitis, ethnicity and seronegative spondyloarthropathies (SpAs) in a New Zealand population. 2567 subjects with uveitis were seen an...

Small choroidal melanoma: outcomes following apical height dose brachytherapy

Nov 05, 2020

The study was done to assess the outcomes of small choroidal melanoma following iodine-125 episcleral brachytherapy. Patients with small choroidal melanoma that underwent iodine-125 episcleral brachy...

Heritability of macular ganglion cell inner plexiform layer thickness as determined by optical coherence tomography: the Healthy Twin Study

Nov 05, 2020

The study was done to evaluate genetic influence on macular GCIPL thickness. Macular GCIPL thickness was measured with optical coherence tomography in nine macular subfields defined by the E TDRS. Th...

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