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Ophthalmology General

Scleral lens for severe dry eye status post lacrimal gland resection for adenoid cystic carcinoma.

Feb 10, 2020

Scleral contact lenses (SCLs) are devices that allow a fluid reservoir between the contact lens and the cornea, providing both improved lubrication and refraction. Consequently, SCLs have been used fo...

Associations between the menstrual cycle, lifestyle factors and clinical assessment of the ocular surface: a prospective observational study.

Feb 10, 2020

Little is known about the ocular surface changes over the menstrual cycle in young women and the interactions with lifestyle factors. Therefore, the purpose of this study was to explore the associatio...

Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose. Potential use in diabetic retinopathy.

Feb 10, 2020

Alpha-1-antitrypsin is a protein involved in avoidance of different processes that are seen in diabetic retinopathy pathogenesis. These processes include apoptosis, extracellular matrix remodeling and...

Diabetic Retinopathy Screening Using a Gold Nanoparticle-Based Paper Strip Assay for the At-Home Detection of the Urinary Biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG).

Feb 10, 2020

To assess a smartphone-based, gold nanoparticle (AuNP)-based colorimetric lateral flow immunoassay paper sensor for quantifying urine 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker for diabetic r...

The effect of glycaemia on choroidal thickness in different stages of diabetic retinopathy.

Feb 10, 2020

The purpose of this study was to evaluate the influence of renal and glycemic parameters on choroidal thickness (CT) in patients with diabetes with and without diabetic retinopathy (DR).This cross-sec...

An Economic Evaluation of Voretigene Neparvovec for the Treatment of Biallelic RPE65-Mediated Inherited Retinal Dystrophies in the UK.

Feb 10, 2020

Voretigene neparvovec (VN) is a gene therapy and the first approved pharmacological treatment for biallelic RPE65-mediated inherited retinal dystrophies (IRD), a rare condition that starts in early li...

Benzodiazepine Use and Risk of Acute Angle-Closure Glaucoma: A Population-Based Case-Crossover Study.

Feb 10, 2020

Theoretically, benzodiazepines (BZDs) can narrow the iridocorneal angle and induce acute angle-closure glaucoma (AACG). However, little evidence exists regarding this association.The objective of this...

Permanent Visual Work Disabilities

Feb 10, 2020

Visual diseases are the fifth more frequent cause of labour permanent disability, what represents 4% of the total of them. In order to assess these cases we must take into account on one hand the visu...

Biomechanical properties of optic nerve and retrobulbar structures with 2D and 3D shear wave elastography in patients affected by glaucoma.

Feb 10, 2020

This study consists of an elastosonography evaluation of both eyes of 40 glaucomatous patients and 40 healthy subjects. We used shear wave elastography with a one-dimensional-array probe to capture tw...

Low Cost Surrogate Eye Model for Corneal Foreign Body Removal

Feb 10, 2020

Patients commonly present to the Emergency Department with a corneal foreign body (FB). There is currently a lack of adequate training for junior doctors in the management of this condition. Our self-...

Progress in the development of novel therapies for choroideremia.

Feb 04, 2020

There are no currently approved treatments for choroideremia, an X-linked progressive inherited retinal degeneration that leads to blindness by middle age. Several treatment options are being explored...

The effect of acute exercise on environmentally induced symptoms of dry eye.

Feb 04, 2020

The purpose of this study was to investigate the effects of acute exercise on environmentally induced symptoms of dry eye. Twelve participants without dry eye disease volunteered to complete three exp...

Dry eye symptoms and signs in children wearing OK lenses for six months in China.

Feb 04, 2020

This study aims to investigate symptoms of dry eye and signs of ocular surface disease in children with myopia during OK lens wear.A total of 68 subjects were prospectively managed with OK lens correc...

Advances in the diagnosis and treatment of dry eye.

Feb 04, 2020

The core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis (TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film-oriented treatmen...

Ocular Complications in School-Age Children and Adolescents after Allogeneic Bone Marrow Transplantation.

Feb 04, 2020

Determine the ocular complications in school-age children and adolescents surviving at least one year following allogeneic bone marrow transplantation.Retrospective cohort study METHODS: In our instit...

Randomised double-masked placebo-controlled trial of the cumulative treatment efficacy profile of intense pulsed light therapy for meibomian gland dysfunction.

Feb 04, 2020

To assess long-term cumulative treatment effects of intense pulsed light (IPL) therapy in meibomian gland dysfunction (MGD).Eighty-seven symptomatic participants (58 female, mean±SD age, 53±16 years...

The Indian Health Service Primary Care-Based Teleophthalmology Program for Diabetic Eye Disease Surveillance and Management.

Feb 04, 2020

Historically, fewer than half of American Indians and Alaska Natives (AI/AN) with diabetes received the annual diabetic retinopathy (DR) examination that is considered the minimum standard of care; t...

Effect of intravitreal ranibizumab pretreatment on vitrectomy in young patients with proliferative diabetic retinopathy.

Feb 04, 2020

Younger patients who underwent vitrectomy for proliferative diabetic retinopathy (PDR) display more aggressive nature distinguished from the older patients. Preoperative anti-VEGF therapy has been wid...

Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy.

Feb 04, 2020

Intrinsically photosensitive retinal ganglion cells (ipRGCs) control non-visual light responses (e.g. pupillary light reflex and circadian entrainment). Patients with diabetic retinopathy (DR) show re...

Retinal Non-Perfusion in Proliferative Diabetic Retinopathy Before and After Panretinal Photocoagulation Assessed by Wide Field OCT Angiography.

Feb 04, 2020

Wide field swept source OCT angiography (WF SS-OCTA) imaging was compared with ultrawide-field (UWF) fluorescein angiography (FA) imaging to better understand changes in retinal non-perfusion before a...

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