Department of Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA.

Department of Statistics, University of Connecticut, Storrs, CT, 06269, USA.

Department of Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA.

Department of Pediatrics, Vanderbilt University Medical Center, TN, 37232, USA.

Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA.

Department of Public Health Sciences, Penn State University, Hershey, PA, 17033, USA.

Department of Medicine, University of California, San Francisco, CA, 94143, USA.

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, KS, USA.

Symbiome Inc, San Francisco, CA, United States.

Department of Medicine and Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, 48109, USA.

Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA.

Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 63110, USA.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.

Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 63110, USA.

National Jewish Health, Denver, CO, 80206, USA.

Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA.

Asthma, Allergy and Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Department of Pediatrics, Vanderbilt University Medical Center, TN, 37232, USA.

Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 63110, USA; Kipper Institute of Allergy and Immunology, Schneider Children’s Medical Center, Tel Aviv University, 5891000, Tel Aviv, Israel.

Department of Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA.