To estimate the age-standardized incidence, prevalence, and mortality rates of autoimmune diseases including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (...
Emerging evidence suggests that both selective and non-selective Adenosine A receptor (AR) antagonists could effectively protect mice from experimental autoimmune encephalomyelitis (EAE), wh...
Autoimmune neurological diseases (ANDs) are a specific type of autoimmune disease that affect cells within the central and peripheral nervous system. ANDs trigger various physical/neuropsych...
Combining energy management education with high-intensity interval training improves physical functioning and mental health in patients with multiple sclerosis....
Cognitive dysfunction is a pervasive symptom of multiple sclerosis (MS). Correlational evidence on the relationships between physical activity, sedentary behavior, and cognition has been mix...
We investigated the association between distress symptoms (pain, fatigue, depression, anxiety) and work impairment in four patient populations: multiple sclerosis (N = 107), rheumatoid art...
The prevalence and functional burden of the chronic demyelinating disease multiple sclerosis (MS) are well documented; however, little is known about the initial clinical course of alertness...
Treatment for MS within 6 months of the first demyelinating event improved EDSS scores, disability progression, and conversion to secondary progressive MS....
The complement system is an essential component of the innate immune response and plays a vital role in host defense and inflammation. Dysregulation of the complement system, particularly in...
Ras-homologous (Rho) guanosine triphosphatases (GTPases) are considered a central player in regulating various biological processes, extending to immune regulation. Perturbations in Rho GTPa...
Methylglyoxal (MGO) is a highly reactive metabolite generated by glycolysis. Although abnormal accumulation of MGO has been reported in several autoimmune diseases such as multiple sclerosis...
NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting condition...
The joint occurrence of SELs and PRLs, two MRI markers of chronic active lesions in MS, was linked to greater clinical progression in patients with MS. Approximately 15% to 30% of the...
The 18-kDa translocator protein (TSPO) is increasingly recognized as a molecular target for PET imaging of inflammatory responses in various central nervous system (CNS) disorders. However, ...
Late-onset multiple sclerosis (LOMS) is defined as symptoms initiating at an age above 50.This study aims to determine the clinical and epidemiological aspects of LOMS in East-Azerbaijan pro...
Poor sleep is common in multiple sclerosis (MS) and may impact daily functioning. The extent to which disease-modifying therapies (DMTs) contribute to sleep outcomes is under-examined.To com...
Accumulating evidence suggests that dysfunctional adipose tissue (AT) plays a major role in the risk of developing multiple sclerosis (MS), the most common immune-mediated and demyelinating ...
Outcomes are poor for relapsing-remitting MS patients receiving platform therapy (pDMT) as first treatment, but a younger subgroup may benefit from pDMT. In a real-world study of pa...
Pausing DMF treatment in early pregnancy doesn't raise relapse risk, while restarting treatment within a month after delivery reduces postpartum relapses. Interrupting treatment wit...
Knowledge within the field of multiple sclerosis treatment during pregnancy is vital to ensure the most optimal clinical practice. Immunomodulatory treatment in pregnancy could in theory aff...
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