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Ovarian Cancer

Robotic-Assisted Extraperitoneal Paraaortic Lymphadenectomy is Associated with Fewer Surgical Complications: A Post-hoc Analysis of the STELLA-2 randomized trial.

May 24, 2021

To evaluate if extraperitoneal paraaortic lymphadenectomy using a robotic-assisted approach was associated with fewer complications when compared to all other approaches (conventional laparoscopic tra...

Towards population-based genetic screenings for breast and ovarian cancer: A comprehensive review from economic evaluations to patient perspectives.

May 24, 2021

Genetic testing for hereditary breast and ovarian cancer following genetic counseling is based on guidelines that take into account particular features of the personal and family history, and clinical...

Long non-coding RNA-H19 promotes ovarian cancer cell proliferation and migration via the microRNA-140/Wnt1 axis.

May 20, 2021

To explore the effect and underlying molecular mechanism of long non-coding RNA (lncRNA)-H19 on ovarian cancer (OC) cells, a total of 41 cases of OC and adjacent normal tissues were collected. H19 and...

Risks of subsequent primary cancers among breast cancer survivors according to hormone receptor status.

May 20, 2021

This study was aimed at examining the risks of subsequent primary cancers (SPCs) among breast cancer survivors by hormone receptor (HR) status and age at diagnosis.Data from 12 Surveillance, Epidemiol...

hTERT-molecular targeted therapy of ovarian cancer cells via folate-functionalized PLGA nanoparticles co-loaded with MNPs/siRNA/wortmannin.

May 20, 2021

Effective telomerase-molecular targeted cancer therapy might be a promising approach for the efficient treatment of ovarian cancer. Therefore, folate-functionalized PLGA nanoparticles (NPs) were co-lo...

Nano-assembly of ursolic acid with platinum prodrug overcomes multiple deactivation pathways in platinum-resistant ovarian cancer.

May 06, 2021

As the most common cause of gynecological cancer-related deaths worldwide, ovarian cancer requires novel therapy strategies. Pt(ii)-Based antitumor drugs (e.g. cisplatin) are one of the most successfu...

Dietary Vitamin K Intake and the Risk of Pancreatic Cancer: A Prospective Study of 101695 American Adults.

May 06, 2021

No epidemiological studies have been conducted to assess the association of dietary vitamin K intake with the risk of pancreatic cancer. We used prospective data from the Prostate, Lung, Colorectal, a...

Conditional disease-free survival rates and their associated determinants in patients with epithelial ovarian cancer: A 15-year retrospective cohort study.

May 06, 2021

The most common type of ovarian cancer (OC) is epithelial ovarian cancer (EOC) which is the most lethal gynecologic malignancy in adult women.This study aimed to determine the conditional disease-free...

Expanding Lynch Syndrome Screening to Include Ovarian Cancer

Apr 02, 2021

Although the benefits of universal screening for colorectal cancer (CRC) and endometrial cancer (EC) are well known and supported by widespread consensus among major medical and specialty societies, t...

Family history and pathogenic/likely pathogenic germline variants in prostate cancer patients.

Mar 25, 2021

Recent literature highlights the importance of germline genetic testing in prostate cancer (PCa) patients. Surprisingly, a literature review indicates that family history (FH) records are incomplete i...

Chronic Difficulties are Associated with Poorer Psychosocial Functioning in the First Year Post-Diagnosis in Epithelial Ovarian Cancer Patients.

Mar 25, 2021

Ovarian cancer is characterized by poor prognosis, high levels of distress, disturbed sleep, and compromised quality of life (QOL). Although life stressors have been shown to significantly impact phys...

Tumor Forkhead Box Q1 Is Elevated, Correlates with Increased Tumor Size, International Federation of Gynecology and Obstetrics Stage but Worse Overall Survival in Epithelial Ovarian Cancer Patients.

Mar 25, 2021

Forkhead box Q1 (FOXQ1) regulates epithelial ovarian cancer (EOC) cell proliferation, migration, and invasion, while its prognostic effect in EOC patients is unclear. This study aimed to assess FOXQ1...

[Update of the AWMF S2k Guideline "Diagnostics and Assessment of Occupational Asbestos-Related Diseases" - What's New?]

Mar 18, 2021

The S2k guideline "Diagnostics and assessment of occupational asbestos-related diseases" was updated in November 2020. This article summarizes the most important changes. There is a new reference to t...

PD-L1 expression with QR1 and E1L3N antibodies according to histological ovarian cancer subtype: A series of 232 cases.

Mar 18, 2021

Therapeutic strategies for epithelial ovarian cancers are evolving with the advent of immunotherapy, such as PD-L1 inhibitors, with encouraging results. However, little data are available on PDL-1 exp...

Quality of Life and Adverse Events: Prognostic Relationships in Long-Term Ovarian Cancer Survival.

Mar 18, 2021

There is a critical need to identify patient characteristics associated with long-term ovarian cancer survival.Quality of life (QOL), measured by the Functional Assessment of Cancer Therapy-Ovarian-Tr...

Updated Guidance on Fertility Preservation & Post-Treatment Pregnancy in Patients With Post-Pubertal Cancer

Feb 22, 2021

With long-term survivorship increasingly achievable among patients with cancer, many in this population face the outcomes of treatment-related late effects, explain Richard Anderson, MD, PhD, Matteo L...

The RAD51D c.82G>A (p.Val28Met) variant disrupts normal splicing and is associated with hereditary ovarian cancer.

Jan 18, 2021

Mutations in RAD51D are associated with a predisposition to primary ovarian, fallopian tube, and peritoneal carcinoma. Our study aims to characterize a RAD51D missense variant in a hereditary ovarian ...

Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response.

Jan 18, 2021

Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses...

[High-risk screening using magnetic resonance imaging].

Jan 14, 2021

Specialized breast cancer early detection programs with magnetic resonance imaging (MRI) in high-risk patients are by now well established in several countries. In Germany, such a program has been ru...

Deciphering Biophysical Modulation in Ovarian Cancer Cells.

Jan 14, 2021

It has been long known that the oncogenic extracellular environment plays an indispensable role in developing and nurturing cancer cell progression and in resistance to standard treatments. However, b...

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