Advertisement

Oncology / Hematology General

Hospitalized Patients: Trends in Adverse Event Rate

Aug 09, 2022

For a study, researchers sought to assess the shift in the frequency of unfavorable occurrences among hospitalized patients. The Medicare Patient Safety Monitoring System data from 2010 to 2019 wer...

HFNC vs CPAP Therapy on Liberation From Respiratory Support

Aug 09, 2022

For a study, researchers sought to compare high-flow nasal cannula therapy (HFNC) to continuous positive airway pressure (CPAP) to determine which was non-inferior for use as the primary noninvasive r...

Pharmacogenomic Testing for Drug-Gene Interactions Effect: Medication Selection & Remission of Symptoms

Aug 09, 2022

For a study, researchers sought to ascertain if choosing an antidepressant drug was influenced by pharmacogenomic testing and whether such testing improves clinical results. A practical, randomized...

Fluid Bolus Administration Effect on Cardiovascular Collapse

Aug 09, 2022

For a study, researchers sought to assess how fluid bolus delivery affected the incidence of severe hypotension, cardiac arrest, and mortality. Between February 1, 2019, and May 24, 2021, 1,067 cri...

Omecamtiv Mecarbil Effect on Exercise Capacity in HFrEF

Aug 09, 2022

For a study, researchers sought to evaluate the ability of omecamtiv mecarbil, a new direct myosin activator that enhances cardiac function and lowers the risk of cardiovascular mortality or the first...

Effect of Ringer Acetate vs. 4 percent Albumin Solution on Major Adverse Events in Patients Having Cardiac Surgery

Aug 09, 2022

For a study, researchers sought to examine whether using 4% albumin solution instead of Ringer acetate as the cardiopulmonary bypass prime solution and the perioperative intravenous volume replacement...

Income and Life Expectancy Before & During the COVID-19 Pandemic

Aug 09, 2022

For a study, researchers sought to assess the association between income and life expectancy by race and ethnicity and changes in life expectancy in 2020 and 2021. California fatalities from 2015 t...

Intravitreal Aflibercept vs Laser Photocoagulation Effect on Treatment Success of ROP

Aug 09, 2022

For a study, researchers sought to contrast laser photocoagulation with intravitreal aflibercept in newborns with retinopathy of prematurity (ROP) who require therapy. The 24-week, noninferiority, ...

High- vs. Low-Dose Tranexamic Acid Infusion on RBC Transfusion & Adverse Events in Cardiac Surgery

Aug 09, 2022

For a study, researchers sought to evaluate the effectiveness and side effects of high-dose tranexamic acid against low-dose tranexamic acid in patients undergoing cardiopulmonary bypass. During a ...

Pediatric Patients with End-Stage Kidney Disease: Dialysis Facility, Waiting List, and Transplant

Aug 09, 2022

For a study, researchers sought to ascertain if the financial health of dialysis facilities influences whether juvenile patients on maintenance dialysis are placed on the kidney transplant waiting lis...

Gout Flare and Cardiovascular Events in Gout Patients

Aug 09, 2022

For a study, researchers sought to find out if a recent gout flare-up caused a temporary increase in the risk of cardiovascular events. Between January 1, 1997, and December 31, 2020, electronic he...

Graded Sensorimotor Retraining & Pain Intensity in Chronic LBP

Aug 09, 2022

For a study, researchers sought to calculate the impact of a graded sensorimotor retraining intervention (RESOLVE) on chronic low back pain patients' level of pain. Participants with chronic (>3...

TP53 Copy Number & Protein Expression: Mutation Status Across AML Risk Categories

Aug 02, 2022

Although TP53 mutations are a risk factor for acute myeloid leukemia (AML), large-scale integrated genomic-proteomic investigations of TP53 changes in AML patients are limited. For a study, researcher...

Combining CD47 Blockade with Daratumumab Prolongs Survival in Pediatric T-ALL Preclinical Model

Aug 02, 2022

Acute lymphoblastic leukemia (ALL) is children's most frequent kind of cancer. Despite advances in treatment, T-cell acute lymphoblastic leukemia (T-ALL) recurrence is associated with chemoresistance ...

CD34+CD19−CD22+ B-cell Progenitors: Phenotypic Escape in Patients Receiving CD19-directed Therapies

Aug 02, 2022

Immunotherapies targeting CD19 have completely changed the treatment of advanced B-cell acute lymphoblastic leukemia (B-ALL). Despite initially remarkable complete remission (CR) rates, many patients ...

Subsequent Malignancies in Genetically Modified IECs Treated Patients

Aug 02, 2022

Subsequent malignancies were well-documented consequences in cancer patients with long-term follow-up. Recently, genetically modified immune effector (IE) cells have shown efficacy in hematologic mali...

2 SERPINC1 Variants Affecting Asn224 N-glycosylation Cause Severe Thrombophilia

Aug 02, 2022

The most severe congenital thrombophilia, antithrombin deficiency, may be underestimated because certain pathogenic variations were not discovered by usual functional approaches. In 4 unrelated thromb...

Ibrutinib–rituximab and Chemoimmunotherapy in CLL

Aug 02, 2022

The long-term follow-up of the randomized E1912 study comparing the long-term effectiveness of ibrutinib-rituximab (IR) therapy to fludarabine, cyclophosphamide, and rituximab (FCR) therapy is present...

rVWF Prophylaxis in Severe von Willebrand Disease Patients

Aug 02, 2022

Long-term prophylaxis is recommended by international recommendations in patients with von Willebrand disease (VWD) with severe and regular bleeding. Researchers evaluated the effectiveness and safety...

Platelet Reactivity in HIT: ABO O Blood Group Risk Factor

Aug 02, 2022

An immunological reaction to platelet factor 4 (PF4)/heparin complexes can cause a dangerous side effect called heparin-induced thrombocytopenia (HIT). In a large discovery cohort of patients divided ...