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Ovarian Cancer

How tamoxifen (sometimes) induces uterine cancer: affecting the PI3K pathway

Dec 15, 2021

Long-term use of tamoxifen is associated with an increased risk for the development of uterine cancer. New research shows that tamoxifen directly activates a signaling pathway (PIK3) that is a well-kn...

Updated results from RxPONDER confirm importance of menopausal status on treatment efficacy

Dec 14, 2021

The phase 3 RxPONDER trial evaluated the benefit of adjuvant chemotherapy followed by endocrine therapy in women with HR-positive, HER2-negative, early-stage breast cancer and 1–3 positive nodes. Up...

CME/CE: Exploring Healthcare Super-Utilization in Gynecologic Oncology

Sep 13, 2021

Upon completion of the educational activity, participants should be able to: Discuss a study that examined the prevalence of healthcare super-utilization among gynecologic oncology patients....

Hsa_circ_0004712 downregulation attenuates ovarian cancer malignant development by targeting the miR-331-3p/FZD4 pathway.

Sep 13, 2021

Circular RNAs (circRNAs) are gradually reported to be implicated in the development of malignant tumors, including ovarian cancer (OC). This paper intended to explore the function and action mechanism...

Trends and age-period-cohort effects on mortality of the three major gynecologic cancers in China from 1990 to 2019: Cervical, ovarian and uterine cancer.

Sep 13, 2021

Gynecologic cancers seriously threaten women's life and health. This study aims to assess the long-term trends of mortality from the three major gynecologic cancers in China and to examine the age-, p...

REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.

Sep 13, 2021

BRCA1/2 mutant tumor cells display an elevated mutation burden, the etiology of which remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous mutations during unperturb...

Associations of preoperative serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels with the prognosis of ovarian cancer.

Aug 30, 2021

The effect of serum lipids on ovarian cancer is controversial. We conducted this study to evaluate the prognostic value of preoperative plasma lipid profile in patients with ovarian cancer.The medical...

Clinical and pathological outcomes of risk-reducing salpingo-oophorectomy for Japanese women with hereditary breast and ovarian cancer.

Aug 30, 2021

To clarify the clinical as well as pathological outcomes in Japanese women with germline pathogenic BRCA1/2 variants who underwent risk-reducing salpingo-oophorectomy (RRSO).This prospective study exa...

[Treatment of advanced epithelial ovarian tumor. Hospital Italiano de Buenos Aires experience].

Aug 30, 2021

Ovarian cancer represents the third gynecological cancer in frequency in Argentina. There is a lack of information on this pathology in our country regarding the treatment and evolution of patients wh...

Disregulations of PURPL and MiR-338-3p Could Serve As Prognosis Biomarkers for Epithelial Ovarian Cancer.

Aug 19, 2021

The present study aimed to explore the expressions of long noncoding RNA (lncRNA) p53 upregulated regulator of p53 levels (PURPL) in different ovarian tissues, and to evaluate the significance of dis...

A Photoacoustic Contrast Agent for miR-21 via NIR Fluorescent Hybridization Chain Reaction.

Aug 19, 2021

Nucleic acids are well-established biomarkers of cancer with immense value in diagnostics and basic research. However, strategies to monitor these species in tissue can be challenging due to the need ...

CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance.

Aug 19, 2021

Despite wide use of anti-vascular endothelial growth factor (VEGF) therapy for many solid cancers, most individuals become resistant to this therapy, leading to disease progression. Therefore, new bio...

Clinical indicators useful in decision-making about palliative chemotherapy for end-of-life ovarian cancer patients.

Aug 05, 2021

Chemotherapy for end-of-life ovarian cancer patients is a complex and delicate problem. We evaluated whether active palliative chemotherapy is beneficial for such patients using inflammatory parameter...

Factors impacting the time to ovarian cancer diagnosis based on classic symptom presentation in the United States.

Aug 05, 2021

Patients with ovarian cancer often present with late-stage disease and nonspecific symptoms, but little is known about factors affecting the time to diagnosis (TTD) in the United States.A retrospectiv...

Lapatinib and poziotinib overcome ABCB1-mediated paclitaxel resistance in ovarian cancer.

Aug 05, 2021

Conventional frontline treatment for ovarian cancer consists of successive chemotherapy cycles of paclitaxel and platinum. Despite the initial favorable responses for most patients, chemotherapy resis...

promotes cancer progression through regulation of in oral squamous cell carcinoma (OSCC).

Jul 22, 2021

Genetic studies have revealed a critical role of the distal-less homeobox gene 5 () in the pathogenesis of ovarian cancer, lung cancer, and T-cell lymphoma; however, the role and underlying mechanisms...

Inherited Mutations in Men Undergoing Multigene Panel Testing for Prostate Cancer: Emerging Implications for Personalized Prostate Cancer Genetic Evaluation.

Jun 28, 2021

Multigene panels are commercially available for the evaluation of prostate cancer (PCA) predisposition, which necessitates tailored genetic counseling (GC) for men. Here we describe emerging results o...

NUT Carcinoma in the Pelvic Cavity With Unusual Pathologic Features.

Jun 28, 2021

NUT carcinoma is an aggressive epithelial malignancy defined by NUTM1 translocation, usually arising in the head/neck or thorax regions and showing squamous differentiation. Herein, we describe an ext...

The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.

Jun 24, 2021

Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due to late diagnosis and resistance to chemotherapy, the 5-year survival rate in patients with OC is below 40%....

Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.

Jun 24, 2021

High-grade serous tubo-ovarian carcinoma (HGSC) is a major cause of cancer-related death. Treatment is not uniform, with some patients undergoing primary debulking surgery followed by chemotherapy (PD...