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Ophthalmology General

Inhibition of Aberrant α(1,2)-Fucosylation at Ocular Surface Ameliorates Dry Eye Disease.

Aug 09, 2021

Fucosylation is involved in a wide range of biological processes from cellular adhesion to immune regulation. Although the upregulation of fucosylated glycans was reported in diseased corneas, its imp...

A spectroscopic approach to measuring meibum lipid composition and conformation in donors with Sjӧgren's syndrome.

Aug 09, 2021

Patients with Sjӧgren's syndrome (SS) have dry eye associated with meibomian gland dysfunction (MGD). The meibum from donors with dry eye due to MGD but without SS (M) presents with lower levels of c...

Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil.

Aug 09, 2021

Although the well-established role of the HLA genes on the predisposition of type 1 diabetes (T1D), its contribution to the development and progression of diabetic retinopathy is still unclear, especi...

DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.

Aug 09, 2021

Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism...

Support vector machine and deep-learning object detection for localisation of hard exudates.

Aug 09, 2021

Hard exudates are one of the main clinical findings in the retinal images of patients with diabetic retinopathy. Detecting them early significantly impacts the treatment of underlying diseases; theref...

Vascular biomarkers from optical coherence tomography angiography and glaucoma: where do we stand in 2021?

Aug 09, 2021

Biomarkers of ocular blood flow originating from a wide variety of imaging modalities have been associated with glaucoma onset and progression for many decades. Advancements in imaging platforms inclu...

The Layered Anatomy of the Nose: An Ultrasound-Based Investigation.

Aug 09, 2021

An increasing number of soft tissue filler procedures in the nasal region has been reported. Concomitant with demand, the number of complications has risen due to the difficulty in administering fille...

Comparing a Home Vision Self-Assessment Test to Office-Based Snellen Visual Acuity.

Aug 09, 2021

To evaluate the agreement of a home vision screening test compared to standard in-office technician-measured Snellen visual acuity to allow for remote screening and triaging of patients.In this prospe...

Ophthalmic Injuries After the Port of Beirut Blast-One of Largest Nonnuclear Explosions in History.

Aug 09, 2021

A review of the injury patterns, treatment strategies, and responding physicians' experience during the Port of Beirut blast may help guide future ophthalmic disaster response plans.To present the oph...

Review: Perspective on ocular toxicity of presurgical skin preparations utilizing Chlorhexidine Gluconate/Hibiclens/Chloraprep.

Aug 05, 2021

Chlorhexidine Gluconate (CHG), Hibiclens (4% CHG with 4% Isopropyl Alcohol Detergent), and Chloraprep (i.e. labeled CHG-based solutions), utilized as preoperative surgical preparatory solutions may al...

Associations of refractive errors and retinal changes measured by optical coherence tomography: A systematic review and meta-analysis.

Aug 05, 2021

Studies reporting alteration in retinal thickness using optical coherence tomography (OCT) have been performed in different populations and various degrees of refractive error, producing inconsistent ...

Missense mutation in the gene can cause a complex mild variable phenotype predominated by concomitant strabismus.

Aug 05, 2021

We aimed to reveal the underlying genetic defect in a multigenerational Chinese family with autosomal dominant concomitant strabismus complicated by multiple ocular developmental abnormalities.Compreh...

Spotlight on the Corneal Back Surface Astigmatism: A Review.

Aug 05, 2021

Recent evidence indicates that the corneal back surface astigmatism (CBSA) contributes to the refractive state of the eye in cataract surgery, especially with the implantation of toric intraocular len...

Evaluation of the Repeatability of the LacryDiag Ocular Surface Analyzer for Assessment of the Meibomian Glands and Tear Film.

Aug 05, 2021

This study aimed to determine the intra- and interobserver repeatability of the new LacryDiag Ocular Surface Analyzer and compare it to a similar all-in-one device, the OCULUS Keratograph 5M.Thirty he...

The role of topical N-acetylcysteine in ocular therapeutics.

Aug 05, 2021

N-acetylcysteine (NAC) was first discovered as a mucolytic agent in 1960. We investigate the role of topical NAC in ocular therapeutics, including its mechanism of action, current applications, and ad...

[A multicenter, randomized, double-masked, placebo-controlled trial of compound wild chrysanthemum eye masks for mild and moderate dry eye].

Aug 05, 2021

To investigate the clinical efficacy and safety of compound wild chrysanthemum eye masks for mild and moderate dry eye. In this double-masked, multicenter, placebo-controlled, randomized trial, midd...

Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation.

Aug 05, 2021

Chronic low-grade retinal inflammation is an essential contributor to the pathogenesis of diabetic retinopathy (DR). It is characterized by increased retinal cell expression and secretion of a variety...

Metabolomics in Diabetic Retinopathy: A Systematic Review.

Aug 05, 2021

Diabetic retinopathy (DR), a common microvascular complication of diabetes, is the leading cause of acquired blindness in the working-age population. Individuals with diabetes still develop DR despite...

Proliferative diabetic retinopathy treated with intravitreal ranibizumab and photocoagulation directed at ischemic retinal areas-A randomized study.

Aug 05, 2021

To compare ETDRS panretinal laser photocoagulation (PRP) combined with intravitreal injection of ranibizumab (IVR) and photocoagulation targeted to ischemic retina (PIR) combined with IVR in patients ...

Menstrual hygiene management strategies used by women who are blind or have low vision.

Aug 05, 2021

Menstrual hygiene management is a global public health issue that requires local and individualized support to reduce activity limitations and enable safe, independent task performance for people with...

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