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Ophthalmology General

Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health.

Aug 30, 2021

Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that contains both signaling mediators and structural components of lipid biofilms in humans. The majority of endogeno...

Tauroursodeoxycholic Acid Protects Retinal and Visual Function in a Mouse Model of Type 1 Diabetes.

Aug 30, 2021

Previous studies demonstrated that systemic treatment with tauroursodeoxycholic acid (TUDCA) is protective in in vivo mouse models of retinal degeneration and in culture models of hyperglycemia. This ...

Neurovascular Unit: A New Target for Treating Early Stages of Diabetic Retinopathy.

Aug 30, 2021

The concept of diabetic retinopathy as a microvascular disease has evolved and is now considered a more complex diabetic complication in which neurovascular unit impairment plays an essential role and...

NGF in Inflammatory and Neurodegenerative Diseases of the Eye: New Findings Supporting Neuroprotection and Proper Tissue Remodeling in Vitreoretinal Disorders.

Aug 30, 2021

Nerve growth factor (NGF) plays a crucial role in retinal disorders, as suggested by in vitro/in vivo models. The major effect embraces the neuroprotective activity on retinal ganglion cells (RGCs) un...

Applications of CRISPR as a potential therapeutic.

Aug 30, 2021

Genetic disorders and congenital abnormalities are present in 2-5% of births all over the world and can cause up to 50% of all early childhood deaths. The establishment of sophisticated and controlled...

The Singapore Asymptomatic Narrow Angles Laser Iridotomy Study (ANA-LIS): 5 year results of a Randomized Controlled Trial.

Aug 30, 2021

To examine the efficacy of laser peripheral iridotomy (LPI) in subjects diagnosed as primary angle closure suspects (PACS) DESIGN: Prospective, randomized controlled trial PARTICIPANTS: This multi-cen...

Intravitreal Pharmacotherapies for Diabetic Macular Edema: A Report by the American Academy of Ophthalmology.

Aug 30, 2021

To review the evidence on the safety and efficacy of current anti-vascular endothelial growth factor (VEGF) and intravitreal corticosteroid pharmacotherapies for the treatment of diabetic macular edem...

Adjustable Sutures in the Treatment of Strabismus: A Report by the American Academy of Ophthalmology.

Aug 30, 2021

To review the scientific literature that evaluates the effectiveness of adjustable sutures in the management of strabismus for adult and pediatric patients.Literature searches were performed in the Pu...

Treatment of Neovascular Age-Related Macular Degeneration: An Economic Cost-Risk Analysis of Anti-VEGF agents.

Aug 30, 2021

To find the best cost-effective NVAMD treatment to improve vision while avoiding complications. The model is based on a cost-risk tradeoff analysis from policymakers' perspective.A powerful and flexib...

Screening for Prediabetes and Type 2 Diabetes: US Preventive Services Task Force Recommendation Statement.

Aug 26, 2021

An estimated 13% of all US adults (18 years or older) have diabetes, and 34.5% meet criteria for prediabetes. The prevalences of prediabetes and diabetes are higher in older adults. Estimates of the r...

Changes in corneal curvature and visual acuity in North Indian adults after pterygium excision with modified sutureless, glueless limbal-conjunctival autograft.

Aug 26, 2021

To identify the exact time point during after following pterygium excision with a modified technique of sutureless, glueless limbal-conjunctival autograft, when stabilization of the change in corneal ...

Pterygium surgery by double-sliding flaps procedure: Comparison between primary and recurrent pterygia.

Aug 26, 2021

This study aimed to evaluate the surgical outcomes of pterygial excision for primary and recurrent pterygia by a single method of pterygia excision combined with two conjunctival flaps.This retrospect...

A cross-sectional study to determine the normal corneal epithelial thickness in Indian population using 9-mm wide optical coherence tomography scans.

Aug 26, 2021

To study the corneal epithelial thickness with 9-mm scans of optical coherence tomography in normal Indians with appropriate representation of all age groups.This was a cross-sectional observational s...

A clinical study on the correlation between demodex infestation and ocular surface changes in patients with meibomian gland dysfunction.

Aug 26, 2021

To observe the effect of demodex infection on the ocular surface changes of patients with meibomian gland dysfunction (MGD) and analyze the correlation between the number of demodex and the changes of...

Ocular Surface Disease Index and the five-item dry eye questionnaire: A comparison in Indian patients with dry eye disease.

Aug 26, 2021

To compare the suitability of the Ocular Surface Disease Index (OSDI) and the 5-item Dry Eye Questionnaire (DEQ-5) in Indian patients with dry eyes.This cross-sectional study evaluated the OSDI and DE...

IL-36α/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress.

Aug 26, 2021

To explore the distinct expression and diverse roles of IL-36 cytokines in dry eye disease using an in vitro hyperosmolarity model of human corneal epithelial cells (HCECs).Primary HCECs were cultured...

What colour are your eyes? Teaching the genetics of eye colour & colour vision. Edridge Green Lecture RCOphth Annual Congress Glasgow May 2019.

Aug 26, 2021

Eye colour and colour perception are excellent examples to use when teaching genetics as they encompass not simply the basic Mendelian genetics of dominant, recessive and X-linked disorders, but also ...

Ten-year outcome of anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration.

Aug 26, 2021

The aim of this study was to report the 10-year visual outcome in eyes treated with anti-vascular endothelial growth factor (anti-VEGF) agents for neovascular age-related macular degeneration (nAMD) a...

Automatic Localization of the Scleral Spur Using Deep Learning and Ultrasound Biomicroscopy.

Aug 26, 2021

The purpose of this study was to develop a convolutional neural network (CNN) for automated localization of the scleral spur in ultrasound biomicroscopy (UBM) images of open-angle eyes.UBM images were...

Neurally-constrained modeling of human gaze strategies in a change blindness task.

Aug 26, 2021

Despite possessing the capacity for selective attention, we often fail to notice the obvious. We investigated participants' (n = 39) failures to detect salient changes in a change blindness experiment...

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