Feb 19, 2021

This study aimed to examine the kidney effects of the SGLT2 inhibitor dapagliflozin in patients with proteinuric kidney disease without diabetes. Participants  were haphazardly allocated (1:1) to get...

Feb 19, 2021

Maternal overweight and obesity might increase risks of adiposity and cardiovascular and metabolic diseases in offspring. We examined associations between maternal overweight and obesity severity and ...

Feb 18, 2021

Although clinicians often measure the serum concentration of androgens in premenopausal women presenting with sexual dysfunction, with some women given testosterone or dehydroepiandrosterone as treatm...

Feb 18, 2021

Recombinant human growth hormone has been used for more than 30 years and its indications have increased worldwide. There is concern that this treatment might increase mortality, but published data ar...

Feb 18, 2021

The validation of bone mineral density (BMD) as a surrogate outcome for fracture would allow the size of future randomised controlled osteoporosis registration trials to be reduced. We aimed to determ...

Feb 18, 2021

Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion of adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity of...

Feb 18, 2021

Alkaptonuria is a rare, genetic, multisystem disease characterised by the accumulation of homogentisic acid (HGA). No HGA-lowering therapy has been approved to date. The aim of SONIA 2 was to investig...

Feb 18, 2021

Cushing's disease is a rare endocrine disorder characterised by cortisol overproduction with severe complications. Therapies for cortisol reduction are often necessary. Here we report the outcomes fro...

Feb 17, 2021

The study aims to understand the long term results of using Zenith Alpha thoracic stent-graft for aortic repairs. It is a retrospective study on 44 consecutive subjects (25 male) with a minimum of fi...

Feb 17, 2021

The study aims to understand the efficiency and safety of using the ISNF (in-situ needle fenestration) method for LSA (left subclavian artery) reconstruction during TEVAR (thoracic endovascular aortic...

Feb 17, 2021

The study aims to understand the efficiency of using MFM in treating type B aortic dissection in patients at a single center. The study covered 23 patients in 36 months with type B aortic dissections...

Feb 17, 2021

The study understands the hemodynamic consequences of TEVAR by comparing vorticity profiles and wall shear stress (pre and post-operative) using CFD simulations. The researchers studied CT scans of 2...

Feb 17, 2021

The study aims to understand the outcomes and incidences of cerebral embolic events while using left upper extremity access (LUE) and right upper extremity access (RUE) during f/bEVAR (fenestrated or ...

Feb 17, 2021

The DEPICT-1 and DEPICT-2 studies showed that dapagliflozin as an adjunct to insulin in individuals with inadequately controlled type 1 diabetes improved glycaemic control and bodyweight, without incr...

Feb 17, 2021

Although metformin is increasingly being used in women with type 2 diabetes during pregnancy, little data exists on the benefits and harms of metformin use on pregnancy outcomes in these women. We aim...

Feb 17, 2021

Diabetes has been associated with increased COVID-19-related mortality, but the association between modifiable risk factors, including hyperglycemia and obesity, and COVID-19-related mortality among p...

Feb 17, 2021

Although diabetes has been associated with COVID-19-related mortality, the absolute and relative risks for type 1 and type 2 diabetes are unknown. We assessed the independent effects of diabetes statu...

Feb 17, 2021

Adrenal tumours are commonly encountered in clinical practice, but epidemiological data mainly originate from referral centres. We aimed to determine incidence, prevalence, and rates of malignancy and...

Feb 17, 2021

Patients with type 2 diabetes have a high risk of developing chronic kidney disease. We examined the effects of semaglutide on kidney function and safety in a large, broad type 2 diabetes population. ...

Feb 17, 2021

The melanocortin 4 receptor (MC4R), a component of the leptin–melanocortin pathway, plays a part in body weight regulation. Severe early-onset obesity can be caused by biallelic variants in genes th...