The main objective of this in vivo study was to investigate the effect of different low-level laser therapy (LLLT) doses on polycystic ovary syndrome (PCOS). In the present experimental study, a single dosage of estradiol valerate (EV) was administered to induce PCOS in female rats. After administration of the EV for induction of PCOS, rats were divided into 5 groups (n = 8/group): C group (animals that were not exposed to any form of procedure), PC group (no treatment following EV induction), L group (1 J/cm LLLT treatment following EV induction), L group (2 J/cm LLLT treatment following EV induction), L group (6 J/cm LLLT treatment following EV induction). The results indicated that no significant difference was found in the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and progesterone (P4) between the C and L groups (p < 0.05). Although the serum levels of testosterone (T) were significantly higher in the C group compared with other groups (p < 0.05), the L group was determined to be the closest to the C group. Additionally, the LH, FSH, and T receptor level of the L group was closest to the C group. In conclusion, a 2 J/cm dosage of LLLT (L group) can be considered the most potentially effective treatment of PCOS in the rat. However, more studies are needed to determine the optimal dose of LLLT for the treatment of PCOS.© 2023. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
