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Critical Care General

Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo.

Mar 02, 2020

The bacteria LPS is one of the leading endotoxins responsible for sepsis; its sensing pathway-induced pyroptosis plays an important role in innate immunity. However, excessive pyroptosis might cause i...

Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate.

Mar 02, 2020

Handling of submicron-sized objects is important in many biochemical and biomedical applications, but few methods today can precisely manipulate this range of particles. We present gradient acoustic f...

All change in the prostate cancer diagnostic pathway.

Mar 02, 2020

Following detection of high levels of serum prostate-specific antigen, many men are advised to have transrectal ultrasound-guided biopsy in an attempt to locate a cancer. This nontargeted approach lac...

Sepsis in Burned Adult Patients: Study of Serie of Cases in Brazil.

Mar 02, 2020

Sepsis is currently the leading cause of death in burned patients. There are few studies on sepsis in burned patients at Intensive Care Unit (ICU).To determine demographic profile, clinical presentati...

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia.

Mar 02, 2020

Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In examining bronchoalveolar lavages (BALs) of children with CAP, we found...

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update.

Mar 02, 2020

The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) f...

Nepal: country report on children's environmental health.

Mar 02, 2020

Although Nepal is a country rich in natural beauty, along with an abundance of natural resources, the children of this diverse nation still face several serious health issues arising from their own en...

Characteristics of COVID-19 infection in Beijing.

Mar 02, 2020

Since the first case of a novel coronavirus (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Beijing. We analyzed the data of 262 ...

Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis.

Mar 02, 2020

Sepsis is a life-threatening response to infection associated with inflammation, oxidative stress and mitochondrial dysfunction. We investigated differential effects of three forms of vitamin E, which...

Analytical Evaluation of the New Beckman Coulter Access Procalcitonin (PCT) Chemiluminescent Immunoassay.

Mar 02, 2020

This study was designed to evaluate the analytical performance of the recently commercialized Beckman Coulter Access procalcitonin (PCT) chemiluminescent test on the Access immunoassay system. The ana...

Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice.

Mar 02, 2020

Staphylococcus aureus (S. aureus) arthritis is one of the most detrimental joint diseases known and leads to severe joint destruction within days. We hypothesized that the provision of auxiliary immun...

Anti-pituitary and anti-hypothalamus autoantibody associations with inflammation and hypogonadotropic hypogonadism in men with traumatic brain injury.

Mar 02, 2020

Traumatic brain injury (TBI) and can lead to persistent hypogonadotropic hypogonadism (PHH) and poor outcomes. We hypothesized that autoimmune and inflammatory mechanisms contribute to PHH pathogenesi...

Is Pediatric Traumatic Brain Injury Associated with Adult Alcohol Misuse?

Mar 02, 2020

Evidence suggests that pediatric traumatic brain injury (TBI) may be causally related to alcohol misuse later in life; however, the nature and extent of the association has not been well described. Th...

Head injury and helmet usage trends for alpine skiers and snowboarders in western Canada during the decade 2008-9 to 2017-18.

Mar 02, 2020

This research explores snowsport head injury trends in western Canadian resorts over the decade 2008-2018.Ecological study.Head-injury and participation data on alpine skiing and snowboarding (snowspo...

Necrostatin-1 prevents the proapoptotic protein Bcl-2/adenovirus E1B 19-kDa interacting protein 3 from integration into mitochondria.

Mar 02, 2020

Necrostatin-1 (Nec-1) has previously been shown to protect neurons from death in traumatic and ischemic brain injuries. The present study tests the hypothesis that Nec-1 protects neural cells against ...

Alcohol Use Disorders and the Brain.

Mar 02, 2020

A diagnosis of alcohol use disorder is associated with a higher risk of dementia but a dose-response relationship between alcohol intake consumption and cognitive impairment remains unclear. Alcohol i...

Copeptin - a new diagnostic and prognostic biomarker in neurological and cardiovascular diseases.

Mar 02, 2020

Copeptin, arginine vasopressin (AVP)-associated 39 aminoacid glycopeptide, is a C-terminal part of pro-AVP. AVP acts through V1a, V1b, and V2 receptors. The effect on V1a receptors is connected with ...

INCREASED RISK OF SEVERE MATERNAL MORBIDITY AMONG INFERTILE WOMEN: ANALYSIS OF US CLAIMS DATA.

Mar 02, 2020

Severe maternal morbidity continues to be an issue of national and global concern and is increasing in incidence. The incidence of infertility is also on the rise, and infertile women experience a hig...

Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1.

Mar 02, 2020

Doxorubicin (DOX) is a powerful anthracycline antineoplastic drug whose clinical application is limited by serious cardiotoxic side effects. Dihydromyricetin (DHM), a flavonoid compound extracted from...

Nasal colonization with Staphylococcus aureus is a risk factor for ventricular assist device infection in the first year after implantation: a prospective, single-centre, cohort study.

Mar 02, 2020

To assess, whether S. aureus nasal colonization is a risk factor for infections in patients with durable ventricular assist device (VAD).Prospective, single-centre, cohort study (i) ascertaining S. au...

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