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Critical Care General

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.

Feb 28, 2020

An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus 2 (SARS-CoV-2) started in December, 2019, in Wuhan, China. Information about critically ill patients with SARS...

Intestinal flora dysbiosis aggravates cognitive dysfunction associated with neuroinflammation in heart failure.

Feb 28, 2020

Cognitive dysfunction after heart failure (HF) is characterized by neuroinflammation, which plays an important role in the occurrence and development of cognitive dysfunction. Recent studies have show...

Comparing PCI Approaches for Cardiogenic Shock

Feb 25, 2020

Previous studies indicate that early revascularization appears to reduce mortality among patients with acute MI that is complicated by cardiogenic shock. Approximately 80% of MI patients with cardioge...

Susceptibility of rat steatotic liver to ischemia-reperfusion is treatable with liver-selective matrix metalloproteinase inhibition.

Feb 18, 2020

This study examined whether enhanced susceptibility of steatotic liver to I/R injury is due to impaired recruitment of bone marrow (BM) progenitors of LSECs (also called sprocs) with diminished repair...

Hypoxic-ischemic-related cerebrovascular changes and potential therapeutic strategies in the neonatal brain.

Feb 18, 2020

Perinatal hypoxic-ischemic (HI)-related brain injury is an important cause of morbidity and long-standing disability in newborns. The only currently approved therapeutic strategy available to reduce b...

Mitochondrial division inhibitor 1 disrupts oligodendrocyte Ca homeostasis and mitochondrial function.

Feb 18, 2020

Mitochondrial fission mediated by cytosolic dynamin related protein 1 (Drp1) is essential for mitochondrial quality control but may contribute to apoptosis as well. Blockade of Drp1 with mitochondrial...

Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT.

Feb 18, 2020

BACKGROUND Ischemia-reperfusion injury is caused by a blood reperfusion injury in ischemic brain tissue, and usually occurs in the treatment stage of ischemic disease, which can aggravate brain tissue...

Multistate, population-based distributions of candidate vaccine targets, clonal complexes, and resistance features of invasive Group B Streptococci within the US: 2015-2017.

Feb 18, 2020

Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis and an important cause of invasive infections in pregnant and nonpregnant adults. Vaccines targeting capsule polysaccha...

Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores : A retrospective study.

Feb 18, 2020

To investigate the prognostic value of the presepsin:albumin ratio and C‑reactive protein:albumin ratio in patients with sepsis in the intensive care unit (ICU).A total of 228 (129 males and 99 fem...

Implantation of biologic mesh in ventral hernia repair-does it make sense?

Feb 18, 2020

Biological acellular porcine dermis mesh, such as Permacol™, has been used since 2009 to treat abdominal incisional hernias in a septic context. This study investigated the risk factors for inc...

Low vasopressin and progression of neonatal sepsis to septic shock: a prospective cohort study.

Feb 18, 2020

The study objective was to analyze the association between low plasma vasopressin and progression of sepsis to septic shock in neonates ...

Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.

Feb 18, 2020

In-hospital pediatric sepsis mortality has decreased substantially, but long-term mortality and morbidity among children initially surviving sepsis, is unknown. Accordingly, the Life After Pediatric S...

Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis.

Feb 18, 2020

Systemic endothelial activation may contribute to sepsis-associated organ injury, including acute respiratory distress syndrome. We hypothesized that children with extrapulmonary sepsis with versus wi...

Complement interactions with the pathogenic Neisseriae: clinical features, deficiency states and evasion mechanisms.

Feb 18, 2020

Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea, while Neisseria meningitidis is an important cause of bacterial meningitis and sepsis. Complement is a central arm of innate ...

Peri- and Post-operative Amplitude-integrated Electroencephalography in Infants with Congenital Heart Disease.

Feb 18, 2020

To identify the factors influencing brain injury in infants with congenital heart disease (CHD) after cardiac surgery.This retrospective study investigated 103 infants with CHD undergoing cardiac surg...

[Treatment strategies and outcomes for injection-associated inguinal perivascular abscesses in intravenous drug addicts].

Feb 18, 2020

Long-term drug users regularly present with deep inguinal vascular-associated abscesses due to continued drug injections utilizing superficial veins. The treatment of these complications continues to ...

Effects of RO27-3225 on neurogenesis, PDGFRβ cells and neuroinflammation after cerebral infarction.

Feb 18, 2020

Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melan...

Occupant injuries in light passenger vehicles-A NASS study to enable priorities for development of injury prediction capabilities of human body models.

Feb 18, 2020

To prioritize how the development of mathematical human body models for injury prediction in crash safety analysis should be made, the most frequent injuries in the NASS CDS data from 2000 to 2015 wer...

Differential Expression of Circulating Inflammatory Proteins Following Sport-Related Traumatic Brain Injury.

Feb 18, 2020

Sport-related traumatic brain injury (TBI) elicits a multifaceted inflammatory response leading to brain injury and morbidity. This response could be a predictive tool for the progression of TBI and t...

Changes in macrophage inflammatory protein-1 (MIP-1) family members expression induced by traumatic brain injury in mice.

Feb 18, 2020

A deep knowledge of the profound immunological response induced by traumatic brain injury (TBI) raises the possibility of novel therapeutic interventions. Existing studies have highlighted the importa...

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