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Stroke

#VisualAbstract: Thrombectomy alone is inferior to thrombectomy plus alteplase for acute ischemic stroke

Aug 05, 2022

1. Fewer patients in the thrombectomy group achieved an MRS score of 0-2 at 90 days compared to thrombectomy with alteplase (57% vs. 65%). 2. Thrombectomy with alteplase resulted in significant...

Mechanical Thrombectomy After Stroke Improves Disability & Survival Outcomes

Jul 23, 2022

Strokes are the leading cause of death globally[1] and account for an estimated 140,000 deaths in the United States each year[2]. As medical professionals, it’s very important that we educate patie...

Adding ‘Cancer’ to Risk Calculator May Help Predict Stroke in AF

Jul 14, 2022

Adding “cancer” to the atrial fibrillation prediction model improved the predictability of assessing the probability of stroke-free survival in patients. Several risk assessment tools have ...

Predictors of very early stroke recurrence in the POINT trial population.

May 16, 2022

Recent trials of acute secondary prevention in patients with minor ischemic stroke or transient ischemic attack (TIA) have demonstrated high rates of early recurrence within days of the initial event....

Prevalence of clinical manifestations and neuroimaging features in cerebral small vessel disease.

Apr 25, 2022

Cerebral small vessel disease (CSVD) may present with gradual onset, chronic parkinsonism and/or dementia. In this study, we aimed to identify the prevalence and clinical characteristics of apathy, de...

Dysregulation of Serum miR-138-5p and Its Clinical Significance in Patients with Acute Cerebral Infarction.

Apr 18, 2022

Acute cerebral infarction (ACI) occurs with the involvement of differential expression of microRNAs. The study detected the expression pattern of miR-138-5p in the serum of ACI cases and evaluated its...

Clinical Outcomes and Costs of Recurrent Ischemic Stroke: A Systematic Review.

Apr 11, 2022

Recurrent stroke patients suffer significant morbidity and mortality, representing almost 30% of the stroke population. Our objective was to determine the clinical outcomes and costs of recurrent isch...

Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke

Mar 28, 2022

For a study, researchers sought to determine if adding intra-arterial alteplase after thrombectomy improves outcomes after reperfusion. From December 2018 to May 2021, 7 stroke centers participated in...

The effects of apixaban on clot characteristics in atrial fibrillation: A novel pharmacodynamic biomarker.

Mar 28, 2022

Atrial fibrillation (AF) is a major risk factor for stroke. We aim to characterize AF patients and the effects of apixaban therapy in terms of clot microstructure using gel point analysis, a novel bio...

Serum or Plasma for Quantification of Direct Oral Anticoagulants?

Jan 24, 2022

Direct oral anticoagulants (DOACs) are increasingly replacing vitamin K antagonists for prevention of stroke in patients with atrial fibrillation, partly owing to the lack of a need for routine monito...

Investigating the structure-function relationship of the corticomotor system early after stroke using machine learning.

Jan 10, 2022

Motor outcomes after stroke can be predicted using structural and functional biomarkers of the descending corticomotor pathway, typically measured using magnetic resonance imaging and transcranial mag...

Therapeutic effect of Danhong injection on diabetic patients with cerebral infarction and its influence on vascular endothelial function and hemodynamics.

Dec 06, 2021

To investigate the therapeutic effect of Danhong injection on diabetic patients with cerebral infarction and its influence on vascular endothelial function and hemodynamic level. A total of 100 diabet...

Parameter estimation for closed-loop lumped parameter models of the systemic circulation using synthetic data.

Nov 15, 2021

Physics-based models can be applied to describe mechanisms in both health and disease, which has the potential to accelerate the development of personalized medicine. The aim of this study was to inve...

Independent effects of amyloid and vascular markers on long-term functional outcomes: An 8-year longitudinal study of subcortical vascular cognitive impairment.

Nov 01, 2021

Subcortical vascular cognitive impairment (SVCI) is characterized by the presence of cerebral small vessel disease (CSVD) markers. Some SVCI patients also show Alzheimer's disease and cerebral amyloid...

Etiologies and Mechanisms of Ischemic Stroke Associated with Sexual Intercourse: A Literature Review.

Oct 18, 2021

Exposure to some special events, also called stroke triggers, can precipitate the onset of ischemic stroke (IS). Previous studies have presented preliminary hypotheses about sexual intercourse as a tr...

Predictors of Infarction in Tuberculous Meningitis in Indian Patients.

Sep 20, 2021

Stroke is a devastating complication of tuberculous meningitis (TBM) and is an important determinant of its outcome. We propose a model which would help to predict development of infarction or cerebro...

Pathway-specific cortico-muscular coherence in proximal-to-distal compensation during fine motor control of finger extension after stroke.

Aug 26, 2021

Proximal-to-distal compensation is commonly observed in upper extremity(UE) after stroke, mainly due to the impaired fine motor control in hand joints. However, little is known on its related neural r...

Large Vessel Occlusion Prediction in the Emergency Department with National Institutes of Health Stroke Scale Components: A Machine Learning Approach.

Aug 19, 2021

To determine the feasibility of using a machine learning algorithm to screen for large vessel occlusions (LVO) in the Emergency Department (ED).A retrospective cohort of consecutive ED stroke alerts a...

Investigating the "Weekend Effect" on Outcomes of Patients Undergoing Endovascular Mechanical Thrombectomy for Ischemic Stroke.

Aug 12, 2021

With growing evidence of its efficacy for patients with large-vessel occlusion (LVO) ischemic stroke, the use of endovascular thrombectomy (EVT) has increased. The "weekend effect," whereby patients p...

A clinical-in silico study on the effectiveness of multipoint bicathodic and cathodic-anodal pacing in cardiac resynchronization therapy.

Aug 02, 2021

Up to one-third of patients undergoing cardiac resynchronization therapy (CRT) are nonresponders. Multipoint bicathodic and cathodic-anodal left ventricle (LV) stimulations could overcome this clinica...