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Ophthalmology General

Retinal organoids in disease modelling and drug discovery: Opportunities and challenges.

Oct 02, 2023

Diseases leading to retinal cell loss can cause severe visual impairment and blindness. The lack of effective therapies to address retinal cell loss and the absence of intrinsic regeneration in the hu...

Association of Private Equity Firm Acquisition of Ophthalmology Practices with Medicare Spending and Utilization of Ophthalmology Services.

Oct 02, 2023

Private equity (PE) firms are increasingly acquiring ophthalmology practices; little is known of their influence on care utilization and spending. We studied changes in utilization and Medicare spendi...

Identification of potential biomarkers of myopia based on machine learning algorithms.

Sep 25, 2023

This study aims to identify potential myopia biomarkers using machine learning algorithms, enhancing myopia diagnosis and prognosis prediction.GSE112155 and GSE15163 datasets from the GEO database wer...

The role of the serotonergic system in atropine's anti-myopic effects.

Sep 25, 2023

The muscarinic cholinergic antagonist atropine is the most widely used pharmacological treatment for the visual disorder myopia (short-sightedness), the leading cause of low-vision worldwide. This stu...

The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.

Sep 25, 2023

The innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental stresses. The epithelium is central to the innate immune response, but wh...

Estrogen plays an important role by influencing the NLRP3 inflammasome.

Sep 25, 2023

The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is an important part of the natural immune system that plays an important role in many diseases. Estrogen is ...

Alterations of outer retinal reflectivity in diabetic patients without clinically detectable retinopathy.

Sep 25, 2023

This study aimed to investigate alterations of outer retinal reflectivity on spectral-domain optical coherence tomography (OCT) in diabetic patients without clinically detectable retinopathy (NDR).In ...

Increasing energetic demands on photoreceptors in diabetes corrects retinal lipid dysmetabolism and reduces subsequent microvascular damage.

Sep 25, 2023

Mechanisms responsible for the pathogenesis of diabetic retinal disease remain incompletely understood, but likely involve multiple cellular targets, including photoreceptors. Evidence suggests that d...

Glaucoma: now and beyond.

Sep 25, 2023

The glaucomas are a group of conditions leading to irreversible sight loss and characterised by progressive loss of retinal ganglion cells. Although not always elevated, intraocular pressure is the on...

Synthesis of novel interpenetrated network for ocular co-administration of timolol maleate and dorzolamide hydrochloride drugs.

Sep 25, 2023

In the present work, novel interpenetrated networks (IPNs) of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide) (SBMA) and poly(vinyl alcohol) (PVA) were prepared for the ocular co...

Demographics, Practice Analysis and Geographic Distribution of Neuro-ophthalmologists in the US in 2023.

Sep 25, 2023

To assess the demographic characteristics and geographic distribution of neuro-ophthalmologists practicing in the US.A cross-sectional study.Neuro-ophthalmologists across the US.In this cross-sectiona...

Ophthalmology Workforce Projections in the United States, 2020-2035.

Sep 25, 2023

To analyze ophthalmology workforce supply and demand projections from 2020 to 2035 DESIGN: Observational cohort studying using data from the National Center for Health Workforce Analysis (NCHWA) METHO...

Predictors of response to a lapse in anti-VEGF treatment in patients with macular edema secondary to retinal vein occlusion.

Sep 18, 2023

Macular edema (ME) in the setting of retinal vein occlusions (RVO) is a common cause of vision loss worldwide. Anti-vascular endothelial growth factor (anti-VEGF) injections are the gold standard for ...

Low concentration atropine and myopia: a narrative review of the evidence for United Kingdom based practitioners.

Sep 18, 2023

The prevalence of myopia is increasing across the world. Controlling myopia progression would be beneficial to reduce adverse outcomes such as retinal detachment and myopic maculopathy which are assoc...

Bidirectional Associations Between Hyperopia, Myopia, Astigmatism, and Strabismus and Attention-Deficit/Hyperactivity Disorder in Children: A National Population-Based Cohort Study.

Sep 18, 2023

The present study analyzed the reciprocal relationships between four common pediatric ophthalmic diseases (i.e., hyperopia, myopia, astigmatism, and strabismus) and ADHD in children.This study enrolle...

Prevalence and Correlates of Dry Eye in a German Population Sample.

Sep 18, 2023

In this cross-sectional survey, we assessed the prevalence of dry eye disease (DED) in a representative German population sample. In addition, we examined the associations between DED, health-related ...

Topographic Correlation of Microperimetry with Structural Characteristics in Diabetic Macular Ischemia.

Sep 18, 2023

This study aimed to determine the threshold for defining abnormal retinal sensitivity (RS) that correlates with structural changes in diabetic macular ischemia (DMI) patients with stable treated proli...

Protective effect of evolocumab on Müller cells in the rat retina under hyperglycaemic and hypoxic conditions.

Sep 18, 2023

In this study, rat retinal Müller cells (RMCs) were cultured in vitro to investigate the protective mechanism of evolocumab on rat RMCs in diabetes mellitus (DM) and the expression of relevant inflam...

Outcomes of hyperbaric oxygen treatment for central and branch retinal artery occlusion at a major Australian referral hospital.

Sep 18, 2023

This study analysed the treatment outcomes of patients that received hyperbaric oxygen treatment (HBOT) for retinal artery occlusion (RAO) at the Royal Brisbane and Women's Hospital in Brisbane, Austr...

Development and testing of a metabolic chamber for effluent collection during whole eye perfusions.

Sep 18, 2023

Ocular hypertension is caused by dysregulated outflow resistance regulation by the conventional outflow (CO) pathway. The physiology of the CO pathway can be directly studied during ex vivo ocular per...

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