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Ophthalmology General

Wavefront excimer laser refractive surgery for adults with refractive errors.

Dec 21, 2020

Refractive errors (conditions in which the eye fails to focus objects accurately on the retina due to defects in the refractive system), are the most common cause of visual impairment. Myopia, hyperop...

Incidence and Outcomes of Suprachoroidal Hemorrhage Following Aurolab Aqueous Drainage Implant in Adult and Pediatric Glaucoma.

Dec 21, 2020

Postoperative suprachoroidal hemorrhage is an infrequent but devastating complication after non-valved aqueous drainage implant surgery and demonstrated a bimodal distribution. The final outcomes of e...

Intravitreal Anti-Vascular Endothelial Growth Factor Injection versus Laser Photocoagulation for Retinopathy of Prematurity: A Meta-Analysis of 3701 Eyes.

Dec 21, 2020

We investigate the efficacy and safety of intravitreal injection (IVI) of anti-vascular endothelial growth factor agents and laser photocoagulation (LPC) for retinopathy of prematurity (ROP). We perfo...

Assessment of patient burden from dry eye disease using a combination of five visual analogue scales and a radar graph: a pilot study of the PENTASCORE.

Dec 21, 2020

Dry eye disease (DED) questionnaires would ideally be easy and fast to answer and explore the main aspects of disease burden and satisfaction (efficacy and tolerability) with treatment. This pilot stu...

An Association Rule Analysis of Combined Acupoints for the Treatment of Patients with Dry Eye Disease.

Dec 21, 2020

Dry eye disease (DED) has a higher incidence in old age and is seen predominantly in females worldwide. Neurosensory abnormalities, ocular surface inflammation and damage, film instability, and hypero...

Dry Eye Disease Association with Computer Exposure Time Among Subjects with Computer Vision Syndrome.

Dec 21, 2020

To assess the time of exposure to the computer and dry eye disease (DED) in subjects with computer vision syndrome (CVS).A cross-sectional study was conducted in office workers, computer users of both...

Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-induced Retinal Dysfunction and Neurodegeneration through Rhodopsin.

Dec 21, 2020

Diabetic patients often experience visual defects before any retinal pathologies are detected. The molecular mechanism for the visual defects in early diabetes has not been elucidated. Our previous st...

Human plasminogen-derived N-acetyl-Arg-Leu-Tyr-Glu antagonizes VEGFR-2 to prevent blood-retinal barrier breakdown in diabetic mice.

Dec 21, 2020

Targeting the vascular endothelial growth factor (VEGF)/its receptor-2 (VEGFR-2) system has become a mainstay of treatment for many human diseases, including retinal diseases. We examined the therapeu...

Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats.

Dec 21, 2020

Diabetes mellitus is a common metabolic disease leading to hyperglycemia due to insufficient pancreatic insulin production or effect. Amine oxidase copper containing 3 (AOC3) is an enzyme that belongs...

Common aspects between glaucoma and brain neurodegeneration.

Dec 21, 2020

Neurodegeneration can be defined as progressive cell damage to nervous system cells, and more specifically to neurons, which involves morphologic alterations and progressive loss of function until cel...

A Service Coverage Analysis of Primary Congenital Glaucoma Care Across the United States.

Dec 21, 2020

To assess the number of infants at risk of delayed primary congenital glaucoma (PCG) evaluation due to long travel times to specialists.Cross-sectional geospatial service coverage analysis.All America...

Dominant optic atrophy: Culprit mitochondria in the optic nerve.

Dec 21, 2020

Dominant optic atrophy (DOA) is an inherited mitochondrial disease leading to specific degeneration of retinal ganglion cells (RGCs), thus compromising transmission of visual information from the reti...

Ophthalmology training in sub-Saharan Africa: a scoping review.

Dec 21, 2020

Sub-Saharan Africa is home to 12% of the global population, and 4.3 million are blind and over 15 million are visually impaired. There are only 2.5 ophthalmologists per million people in SSA. Training...

Surgical Grade and Repeat Laser Peripheral Iridotomy Procedures with Risk Stratification and Educational Considerations.

Dec 21, 2020

Peripheral laser iridotomy (PLI) is a commonly performed procedure. While effective, repeat procedures (RPs) may be required for a variety of causes. We report the causes and rate of RP PLI and whethe...

Social cognition in the blind brain: A coordinate-based meta-analysis.

Dec 17, 2020

Social cognition skills are typically acquired on the basis of visual information (e.g., the observation of gaze, facial expressions, gestures). In light of this, a critical issue is whether and how t...

Various cross-linking methods inhibit the collagenase I degradation of rabbit scleral tissue.

Dec 17, 2020

Collagen cross-linking of the sclera is a promising approach to strengthen scleral rigidity and thus to inhibit eye growth in progressive myopia. Additionally, cross-linking might inhibit degrading pr...

Dysfunction of VIPR2 leads to myopia in humans and mice.

Dec 17, 2020

Myopia is the leading cause of refractive errors. As its pathogenesis is poorly understood, we determined if the retinal VIP-VIPR2 signalling pathway axis has a role in controlling signalling output t...

Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic.

Dec 17, 2020

Homocystinuria due to cystathionine β-synthase (CBS) deficiency, the most frequent inborn error of sulfur amino acid metabolism, is characterized biochemically by severely elevated homocysteine (Hcy)...

Molecular Pharmacology of P2Y Receptor Subtypes.

Dec 17, 2020

Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1 and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular adenine and uracil nucleotide...

Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research.

Dec 17, 2020

Blood vessel sprouting from pre-existing vessels or angiogenesis plays a significant role in tumour progression. Development of novel biomolecules from marine natural sources has a promising role in d...

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