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Ophthalmology General

Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.

Dec 07, 2020

Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contributio...

Glycated Hemoglobin and Blood Pressure Levels in Adults With Type 2 Diabetes: How Many Patients Are on Target?

Dec 07, 2020

Achieving glycated hemoglobin (A1C) and blood pressure targets is an important strategy for preventing chronic vascular complications in diabetes. Our aim in this study was to determine the proportion...

Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of p-c-Jun expression.

Dec 07, 2020

Excitotoxicity is involved in the retinal neuronal cell death in diabetic retinopathy. Although fenofibrate has been shown to ameliorate the progression of diabetic retinopathy, the effect of pemafibr...

Endoscopic Vitreoretinal Surgery: Review of Current Applications and Future Trends.

Dec 07, 2020

Endoscopy provides unique optical properties to circumvent anterior segment opacities and visualize difficult-to-access anatomical regions, including retroirideal, retrolental, ciliary body and anteri...

Protection of ζ-crystallin by α-crystallin under thermal stress.

Dec 07, 2020

Cataract is one of the major causes of blindness worldwide. Several factors including post-translational modification, thermal and solar radiations promote cataractogenesis. The camel lens proteins su...

Cataract-causing mutations L45P and Y46D promote γC-crystallin aggregation by disturbing hydrogen bonds network in the second Greek key motif.

Dec 07, 2020

Congenital cataracts caused by genetic disorders are the primary cause of child blindness across the globe. In this work, we investigated the underlying molecular mechanism of two mutations, L45P and ...

Operative Time and Complication Rates of Resident Phacoemulsification Surgeries in a National University Hospital: A Five-Year Review.

Dec 07, 2020

To determine the operative time and complication rates of resident phacoemulsification surgeries at different time points in training.Retrospective cross-sectional study at the Department of Ophthalmo...

Safety and efficacy of mycophenolate mofetil in treating neuromyelitis optica spectrum disorders: a protocol for systematic review and meta-analysis.

Dec 03, 2020

Neuromyelitis optica spectrum disorders (NMOSD) is an inflammatory and heterogeneous astrocyte disorder of the central nervous system with the characteristic of higher incidence in women and Asian peo...

Natural history and clinical biomarkers of progression in X-linked retinitis pigmentosa: a systematic review.

Dec 03, 2020

X-linked retinitis pigmentosa (XLRP) accounts for a significant proportion of certifiable blindness in working-age adults. The objectives of this study were to: (1) synthesize the best available evide...

[Comparison of sterile donor tomography in the eye bank and graft tomography after penetrating keratoplasty].

Dec 03, 2020

Since 2018 we routinely use sterile donor tomography in the eye bank to avoid refractive surprises after keratoplasty. The purpose of this study was to compare donor tomography parameters measured wit...

Case Report: Use of Prosthetic Replacement of the Ocular Surface Ecosystem Treatment of Traumatic Lid Ptosis in a Pediatric Patient.

Dec 03, 2020

This report shares the long-term outcomes of an uncommon use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment and scleral lenses in the treatment for patients with ptosis wh...

Repeatability and reproducibility of manifest refraction.

Dec 03, 2020

To evaluate the intraexaminer repeatability and the interobserver reproducibility of manifest refraction.Tertiary referral center.Retrospective study.Patients attending at least 2 preoperative refract...

Prevalence of Dry Eye Disease in Africa: A Systematic Review and Meta-analysis.

Dec 03, 2020

Dry eye disease is a significant public health problem globally. The magnitude of the dry eye disease problem in Africa is, however, unknown. This study provides important and lacking information on d...

Presbyopic patient with hyperopia and moderately steep corneas: December consultation #1.

Dec 03, 2020

A 47-year-old woman was referred for refractive surgery evaluation. She has no ocular or medical history. Spectacle dependence is her chief concern. She cannot tolerate contact lens. The corrected nea...

Effect of IRT5 probiotics on dry eye in the experimental dry eye mouse model.

Dec 03, 2020

To investigate the clinical effects of IRT5 probiotics in the environmental dry eye model.Eight week old male C57BL/6 mice were randomly divided into two groups; control group (n = 16) received oral g...

Associations of serum uric acid and urinary albumin with the severity of diabetic retinopathy in individuals with type 2 diabetes.

Dec 03, 2020

Diabetic retinopathy (DR) is a serious microvascular complication of type 2 diabetes mellitus (T2DM). The aim of this retrospective study was to reveal the risk factors for the severity of DR in indiv...

Vessel Density around Foveal Avascular Zone as a Potential Imaging Biomarker for Detecting Preclinical Diabetic Retinopathy: An Optical Coherence Tomography Angiography Study.

Dec 03, 2020

: The purpose of this study was to investigate the changes of optical coherence tomography angiography (OCTA) parameters in diabetic retinopathy (DR) using an updated software with 3D projection artif...

Gut mycobiomes are altered in people with type 2 Diabetes Mellitus and Diabetic Retinopathy.

Dec 03, 2020

Studies have documented dysbiosis in the gut mycobiome in people with Type 2 diabetes mellitus (T2DM). However, it is not known whether dysbiosis in the gut mycobiome of T2DM patients would be reflect...

Secondary epiretinal membrane after Ex-Press glaucoma filtration device implant.

Dec 03, 2020

To estimate the frequency of epiretinal membrane (ERM) in eyes with primary open-angle glaucoma (POAG) treated with Ex-Press shunt implant. Secondarily, we aimed to assess the role of concomitant cata...

Rapid assessment of avoidable blindness and cataract surgery coverage among forcibly displaced Myanmar Nationals (Rohingya refugees) in Cox's Bazar, Bangladesh.

Dec 03, 2020

To determine the prevalence and causes of blindness, vision impairment and cataract surgery coverage among Rohingya refugees aged ≥ 50 years residing in camps in Cox's Bazar, Bangladesh.We used the ...

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