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Ophthalmology General

Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.

Dec 17, 2020

Diabetic retinopathy is characterised by retinal neurodegeneration and retinal vascular abnormalities, affecting one third of diabetic patients with disease duration of more than 10 years. Accumulate...

Effect of Intravitreous Aflibercept vs Vitrectomy With Panretinal Photocoagulation on Visual Acuity in Patients With Vitreous Hemorrhage From Proliferative Diabetic Retinopathy: A Randomized Clinical Trial.

Dec 17, 2020

Vitreous hemorrhage from proliferative diabetic retinopathy can cause loss of vision. The best management approach is unknown.To compare initial treatment with intravitreous aflibercept vs vitrectomy ...

Ophthalmic Drops with Nanoparticles Derived from a Natural Product for Treating Age-Related Macular Degeneration.

Dec 17, 2020

There is a continuing, urgent need for an ophthalmic (eye) drop for the clinical therapy of age-related macular degeneration (AMD), a leading cause of blindness. Here, we report the first formulation ...

Comparison of Clinical Outcomes with Open Versus Closed Conjunctiva Implantation of the XEN45 Gel Stent.

Dec 17, 2020

To describe the efficacy and safety of open versus closed conjunctival implantation of the XEN45 Gel Stent.Retrospective multicenter study.137 patients with glaucoma who underwent XEN45 implantation v...

Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions.

Dec 17, 2020

Age-related macular degeneration (AMD) remains a significant cause of legal blindness, and treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation of the complement...

A polygenic risk score predicts intraocular pressure readings outside office hours and early morning spikes as measured by home tonometry.

Dec 17, 2020

Intraocular pressure (IOP) elevations may occur in early morning or outside office hours and can be missed during routine in-clinic IOP measurements. Such fluctuations or peaks likely contribute to gl...

Effect of fundus tracking on structure-function relationship in glaucoma

Dec 15, 2020

Researchers did this study to investigate the effect of fundus tracking perimetry on structure-function relationship in glaucoma. The researchers included data from 696 eyes from 360 healthy people a...

Acceptability, adherence, and economic analyses of a new clinical pathway

Dec 14, 2020

The researchers did this study to assess whether a new clinical pathway for glaucoma was acceptable to patients and healthcare professionals and whether it provided useful clinical information on non-...

The usefulness of data augmentation for visual field trend analyses

Dec 14, 2020

The researchers conducted this research to investigate the usefulness of data augmentation in the VF trend analyses in patients with glaucoma. This study included a total of 6380 VFs from 638 eyes of...

Visual field progression eight years after trabeculectomy in Asian eyes

Dec 14, 2020

This work aimed to study the effect of long-term IOP fluctuation on the VF progression eight years post-trabeculectomy in Asian eyes. The present study was a retrospective analysis of 8-year post-tra...

Posterior corneal features in patients with Down syndrome

Dec 14, 2020

Researchers did this study to characterise posterior corneal surface features in patients with DS and to compare them with healthy and mild keratoconus corneas. This research was retrospective and no...

The Effects of Transcranial Direct Current Stimulation (tDCS) Combined With Proprioceptive Training for Blind Individuals: The Study Protocol for a Randomized Controlled Clinical Trial.

Dec 14, 2020

To maintain the balance, the postural system needs to integrate the three main sensorial systems: visual, vestibular, and somatosensory to keep postural control within the limits of stabilization. Dam...

Defective INPP5E distribution in NPHP1-related Senior-Loken syndrome.

Dec 14, 2020

Senior-Loken syndrome is a rare genetic disorder that presents with nephronophthisis and retinal degeneration, leading to end-stage renal disease and progressive blindness. The most frequent cause of ...

Individualized Corneal Patching for Treatment of Corneal Trauma Combined with Tissue Defects.

Dec 14, 2020

To evaluate the efficacy of individualized corneal patching using a minimal graft for corneal trauma combined with tissue defects.Fifteen eyes (15 patients) were enrolled in this study, including 8 ey...

Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model.

Dec 14, 2020

In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. Howe...

Combined retinal proteome datasets in response to atropine treatment using iTRAQ and SWATH-MS based proteomics approaches in guinea pig myopia model.

Dec 14, 2020

Atropine, a non-selective muscarinic antagonist, is known to slow down myopia progression in human adolescents and in several animal models. However, its underlying molecular mechanism is unclear. The...

Ocular findings in metabolic syndrome: a review.

Dec 14, 2020

Metabolic syndrome (MetS) has emerged as a worldwide health hazard of the modern lifestyle, representing a cluster of metabolic abnormalities and a risk factor for cardiovascular disease. Eye diseases...

Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery.

Dec 14, 2020

Corneal nerve damage after laser epithelial keratomileusis (LASEK) is thought to be the cause of dry eye and pain. Therefore, we investigated whether taking pregabalin (Lyrica), which reduces peripher...

Abnormal Spontaneous Brain Activities of Limbic-Cortical Circuits in Patients With Dry Eye Disease.

Dec 14, 2020

Whether brain function is altered in patients with dry eye disease (DED) remains unclear. Twenty patients with DED and 23 healthy controls (HCs) were scanned using resting-state functional magnetic re...

Patient and provider perspectives on barriers to screening for diabetic retinopathy: an exploratory study from southern India.

Dec 14, 2020

Diabetic retinopathy is one of the leading causes of visual impairment after cataract and uncorrected refractive error. It has major public health implications globally, especially in countries such a...

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