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Ophthalmology General

LncRNA MALAT 1/miR-625-3p/HIF-1α axis regulates the EMT of hypoxia-induced RPE cells by activating NF-κB/snail signaling.

May 22, 2023

The retina may undergo structural and functional damage as a result of hypoxia, which could lead to permanent blindness. As competing endogenous RNAs (ceRNAs), lncRNAs are essential in eye disorders. ...

ABE8e Corrects Pax6-Aniridic Variant in Humanized Mouse ESCs and via LNPs in Ex Vivo Cortical Neurons.

May 22, 2023

Aniridia is a rare congenital vision-loss disease caused by heterozygous variants in the PAX6 gene. There is no vision-saving therapy, but one exciting approach is to use CRISPR/Cas9 to permanently co...

Efficacy of customized corneal crosslinking versus standard corneal crosslinking in patients with progressive keratoconus (C-CROSS study): study protocol for a randomized controlled trial.

May 22, 2023

Keratoconus is a degenerative disorder of the cornea leading to a protrusion and thinning with loss of visual acuity. The only treatment to halt the progression is corneal crosslinking (CXL), which us...

[Influence of tropical endemic limboconjunctivitis on the distribution of astigmatism in a black pediatric population: A hospital-based case-control study].

May 22, 2023

To study the influence of tropical endemic limboconjunctivitis (TELC) on the distribution of astigmatism in a population of black children.We matched two groups of 36 children between the ages of 3 an...

Neurosensory abnormalities and stability of a novel mouse model of dry eye disease.

May 22, 2023

This study aimed to use a mouse model of dry eye disease (DED) induced by topical administration of benzalkonium chloride (BAK) and assess its stability and the presence of neurosensory abnormalities,...

Evaluation of different treatment modalities on the efficacy of hydroxypropyl Guar (HP-Guar) formulation on tear film stability (TFS) in subjects exposed to adverse environmental conditions.

May 22, 2023

The study aimed to assess the efficacy of hydroxypropyl guar (HP) formulation (Systane) to protect tear film parameters under desiccating environment using protection and relief treatment modalities. ...

Five-year outcomes of digital diabetic eye screening in individuals aged 80 and 85 years.

May 22, 2023

To assess the incidence of referable diabetic retinopathy (DR) in patients aged 80 and 85 years to determine whether screening interval can be extended safely in this age group.Patients who were aged ...

Distribution of the cysteinyl leukotriene system components in the human, rat and mouse eye.

May 22, 2023

The cysteinyl leukotrienes (CysLTs) have important functions in the regulation of inflammation and cellular stress. Blocking the CysLT receptors (CysLTRs) with specific antagonists is beneficial again...

Social Vulnerability, Prevalence of Glaucoma, and Incidence of Glaucoma Surgery in the California Medicare Population.

May 22, 2023

To examine associations of Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry Social Vulnerability Index (SVI) scores with prevalence of glaucoma and incidence...

Social Deprivation and the Risk of Screening Positive for Glaucoma in the MI-SIGHT Telemedicine Based Glaucoma Detection Program.

May 22, 2023

To assess whether increased poverty is associated with increased risk of screening positive for glaucoma or suspected glaucoma in a large public screening and intervention program.Cross-sectional stud...

6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish.

May 15, 2023

The automobile tire antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its quinone metabolite 6PPDQ have recently received much attention for their acute aquatic toxicity. The p...

Demographic and clinical characteristics of age-related distance esotropia.

May 15, 2023

Age-related distance esotropia (ARDE), is an acquired, small, comitant esodeviation that is greater at distance than at near. It occurs in older adult patients without a history of neurological event ...

Subconjunctival Sirolimus-Loaded Liposomes for the Treatment of Moderate-to-Severe Dry Eye Disease.

May 15, 2023

To determine the effectiveness of subconjunctival application of a novel sirolimus liposomal formulation for the treatment of dry eye.A randomized, triple-blind, Phase II clinical trial. Thirty-eight ...

Surgical Punctal Occlusion; Combined Lacrimal Canaliculi Cauterization and Punctal Suturing for Severe Dry Eye.

May 15, 2023

To evaluate the treatment outcome of surgical punctal occlusion with combined canaliculi ablation and punctal suturing in patients with severe dry eye.Eleven eyes of seven patients were diagnosed with...

Extracellular vesicles: an emerging player in retinal homeostasis.

May 15, 2023

Extracellular vesicles (EVs) encompass secreted membrane vesicles of varied sizes, including exosomes (-30-200 nm) and microvesicles (MVs) that are ∼100-1,000 nm in size. EVs play an important rol...

Emerging roles of air pollution and meteorological factors in autoimmune eye diseases.

May 15, 2023

Autoimmune eye diseases (AEDs), a collection of autoimmune inflammatory ocular conditions resulting from the dysregulation of immune system at the ocular level, can target both intraocular and periorb...

Trends in Ophthalmology Practice Consolidation: 2015-2022.

May 15, 2023

To quantify trends in ophthalmology practice consolidation in the United States.A cross-sectional study using physician and group practice Medicare data from 2015 to 2022.Providers in the Centers for ...

The Royal College of Ophthalmologists' National Ophthalmology Database Study of Cataract Surgery: Report 12, Risk factors for suprachoroidal haemorrhage during cataract surgery.

May 15, 2023

To establish the incidence of acute intraoperative suprachoroidal haemorrhage (AISH) during cataract surgery and identify the risk factors for this complication.Data from the Royal College of Ophthalm...

Investigating Visual-Tactile Shape Perception in Individuals With Artificial Vision Restoration

May 10, 2023

The following is a summary of "Visual–tactile shape perception in the visually restored with artificial vision," published in the February 2022 issue of Ophthalmology by Stiles, et al. For a ...

Effect of Orientation-specific Adaptation on Lateral Modulation

May 09, 2023

The following is a summary of "Role of lateral modulation in orientation-specific adaptation effect," published in the February 2022 issue of Ophthalmology by Lin, et al. The normalization proc...

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