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Ophthalmology General

Interferon-γ elicits the ocular surface pathology mimicking dry eye through direct modulation of resident corneal cells.

Jul 03, 2023

Despite accumulating evidence indicating a key role of interferon-γ (IFN-γ)-producing immune cells in ocular infection and immunity, little is known about the direct effects of IFN-γ on resident co...

Interferon-γ elicits the ocular surface pathology mimicking dry eye through direct modulation of resident corneal cells.

Jul 03, 2023

Despite accumulating evidence indicating a key role of interferon-γ (IFN-γ)-producing immune cells in ocular infection and immunity, little is known about the direct effects of IFN-γ on resident co...

REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice.

Jul 03, 2023

Increasing evidence supports a role for inflammation in the early development and progression of retinal complications caused by diabetes. We recently demonstrated that the stress response protein reg...

REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice.

Jul 03, 2023

Increasing evidence supports a role for inflammation in the early development and progression of retinal complications caused by diabetes. We recently demonstrated that the stress response protein reg...

Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage.

Jul 03, 2023

The catabolic process of autophagy is arousing the attention of researchers studying diabetic retinopathy (DR), but the role and molecular mechanism of autophagy in DR are still unclear.An in vivo dia...

Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage.

Jul 03, 2023

The catabolic process of autophagy is arousing the attention of researchers studying diabetic retinopathy (DR), but the role and molecular mechanism of autophagy in DR are still unclear.An in vivo dia...

A knowledge-based decision support system for inferring supportive treatment recommendations for diabetes mellitus.

Jul 03, 2023

Diabetes Mellitus (DM) is a significant risk, mostly causing blindness, kidney failure, heart attack, stroke, and lower limb amputation. A Clinical Decision Support System (CDSS) can assist healthcare...

Timing of antenatal corticosteroids and survival without neurological disabilities at 5½ years in children born before 35 weeks of gestation.

Jul 03, 2023

The efficacy of antenatal corticosteroids on neonatal preterm complications wanes beyond 7 days after treatment. The neurodevelopmental effects of longer treatment-to-birth intervals have not been ade...

The Magnitude of Refractive Error and Its Associated Factors Among Patients Visiting Ophthalmology Clinics in Southern Ethiopia, 2022.

Jul 03, 2023

Refractive error is a vision-impairing condition due to light rays not being able to focus on the retina, resulting in the visual outcome of a cloudy image. It is one of the main causes of central vis...

Short-Term Impact of Different Corneal Incision Positions on Postoperative Astigmatism and Visual Quality After SMILE Surgery.

Jun 19, 2023

This study aimed to evaluate the short-term impact of different incision positions on astigmatism and visual quality after small incision lenticule extraction (SMILE) surgery.This prospective study en...

Complement-mediated inflammation and mitochondrial energy metabolism in the proteomic profile of myopic human corneas.

Jun 19, 2023

Myopia is one of the most common causes of visual impairment worldwide. To identify proteins related to myopiagenesis, data-independent acquisition proteomic analysis was performed using corneal lenti...

Customized designed notch filters and applied effects on glare and contrast sensitivity in patients with dry eye syndrome.

Jun 19, 2023

Glare visual acuity and contrast sensitivity are important indicators of visual quality. Studies have shown that the glare visual acuity and contrast sensitivity in dry eye patients tend to degenerate...

Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway.

Jun 19, 2023

Oxidative stress, inflammation and apoptosis are important pathogenic factors of diabetic retinopathy (DR). In the current study, we aimed to evaluate the potential role of Rhein, a natural anthraquin...

Purtscher-like retinopathy in a 19-year-old with maturity-onset diabetes of the young: a case report.

Jun 19, 2023

We report the first case of Purtscher-like retinopathy in a patient with 17q12 deletion-associated maturity-onset diabetes of the young.A 19-year-old diabetic Hispanic male with history of cataracts a...

The association of physical activity with glaucoma and related traits in the UK Biobank.

Jun 19, 2023

To examine the association of physical activity (PA) with glaucoma and related traits; to assess whether genetic predisposition to glaucoma modified these associations; and to probe causal relationshi...

Evaluation of visual acuity in dry AMD patients after microcurrent electrical stimulation.

Jun 19, 2023

To assess micro current to improve vision for dry age-related macular degeneration. Dry age-related macular degeneration is a major cause of blindness, disability, and severe erosion of quality of lif...

US Population Disparities in Ophthalmic Care: Blindness and Visual Impairment in the IRIS® Registry (Intelligent Research In Sight).

Jun 19, 2023

To evaluate associations of patient characteristics with United States eyecare utilization and likelihood of blindness.Retrospective observational study.19,546,016 patients with 2018 visual acuity (VA...

Race, Ethnicity, Insurance and Population Density Associations with Pediatric Strabismus and Strabismic Amblyopia in the IRIS® Registry.

Jun 19, 2023

To evaluate associations of socio-demographic factors with pediatric strabismus diagnosis and outcomes.Retrospective cohort study.American Academy of Ophthalmology IRIS® Registry (Intelligent Researc...

Association of long-term exposure to ambient air pollution with retinal neurodegeneration: The prospective alienor study.

Jun 12, 2023

Chronic exposure to air pollution may have adverse effects on neurodegenerative diseases. Glaucoma, the second leading cause of blindness worldwide, is a neurodegenerative disease of the optic nerve, ...

Effect of Midface Surgery on Ocular Outcomes in Patients with Orbital and Midface Malformations.

Jun 12, 2023

(1) Background: Orbital and midface malformations occur in multiple craniofacial disorders. Depending on the deformity, surgical corrections include orbital box osteotomy (OBO), Le Fort III (LFIII), m...

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