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Critical Care General

Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion.

Mar 30, 2020

Some researchers have previously shown that RNAi knockdown of arginyl-tRNA synthetase (ArgRS) before or after a hypoxic injury can rescue animals from death, based on the model organism, C. elegans. H...

Knockdown of HIF1A-AS2 suppresses TRIM44 to protect cardiomyocytes against hypoxia-induced injury.

Mar 30, 2020

Myocardial infarction (MI) is a common cardiovascular disease characterized by an interruption of blood and oxygen supply to the heart, which results in gradual damage to the myocardial tissue and ult...

Rivaroxaban in Peripheral Artery Disease after Revascularization.

Mar 30, 2020

Patients with peripheral artery disease who have undergone lower-extremity revascularization are at high risk for major adverse limb and cardiovascular events. The efficacy and safety of rivaroxaban i...

Aspirin Versus Clopidogrel Monotherapy for the Secondary Prevention of Recurrent Cerebrovascular Attack Following Previous Ischemic Stroke in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Mar 30, 2020

Type 2 diabetes mellitus (T2DM) and stroke are two different diseases, but have many aspects in common. Aspirin is recommended as an initial treatment for the secondary prevention of recurrent ischemi...

Hypertensive coronary microvascular dysfunction: a subclinical marker of end organ damage and heart failure.

Mar 30, 2020

Hypertension is a well-established heart failure (HF) risk factor, especially in the context of adverse left ventricular (LV) remodelling. We aimed to use myocardial flow reserve (MFR) and global long...

Ticagrelor for the primary prevention of stroke in patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.

Mar 30, 2020

Coronary artery disease (CAD) patients had a higher risk of first-ever stroke than general population even when they were on antiplatelet treatment. It was unknown whether more potent antiplatelet inh...

Hypersensitivity reactions to bicarbonate dialysate containing acetate: a case report with literature review.

Mar 30, 2020

Although hemodialysis-hypersensitivity reactions have various causes, only a few cases of hypersensitivity to acetate dialysate accompanied by fever have been reported. We present the case of a 69-yea...

Sepsis & Infectious Disease Consultation

Mar 30, 2020

Evidence indicates that the use of severe sepsis and septic shock (SS/SS) treatment bundles is associated with lower mortality when compared with no use. However, delivering successful SS/SS bundles c...

Vitamin C May Reduce Ventilation Time in Critically Ill Patients

Mar 29, 2020

Review shows vitamin C can shorten the duration of mechanical ventilation by an average of 25 percent The administration of vitamin C shortens the length of mechanical ventilation in critically i...

FDA Warns of Defective EpiPen Dangers

Mar 25, 2020

WEDNESDAY, March 25, 2020 (HealthDay News) -- Certain types of EpiPens and their generic counterparts may fail or delay injection of lifesaving epinephrine for severe allergic reactions, the U.S. Food...

A retrospective cohort study to assess PET-CT findings and clinical outcomes in Takayasu arteritis: does 18F-fluorodeoxyglucose uptake in arteries predict relapses?

Mar 23, 2020

The objective of this study is to investigate the use of PET-CT scan with 18F-fluorodeoxyglucose (18F-FDG) as a method to predict outcomes in patients with Takayasu arteritis (TAK), as well as to anal...

Prognostic role of moderate functional tricuspid regurgitation in length of hospitalization in patients undergoing isolated coronary artery bypass grafting.

Mar 23, 2020

Functional tricuspid regurgitation (FTR) is defined as abnormal systolic tricuspid leakage with normal valve structures, and its prognostic role and management in patients with left-heart valve diseas...

Plasma osteopontin levels in patients with acute kidney injury requiring dialysis: a study in a tertiary care institute in South India.

Mar 23, 2020

Osteopontin (OPN) is evolving as a novel biomarker of injury, overall survival and renal outcome in critically ill patients with acute kidney injury (AKI), requiring renal replacement therapy.We perfo...

Association of Early-Onset Sepsis and Vitamin D Deficiency in Term Neonates.

Mar 23, 2020

To determine if vitamin D status is affected in term neonates with early onset sepsis and its association with outcome.Study was done at a level 3 neonatal unit on 140 neonates. Term neonates with ear...

Fibrin exposure triggers αIIbβ3-independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge-dependent manner.

Mar 23, 2020

Collagen and fibrin engagement and activation of glycoprotein (GP) VI induces proteolytic cleavage of the GPVI ectodomain generating shed soluble GPVI (sGPVI). Collagen-mediated GPVI shedding requires...

Engineered silver nanoparticle (Ag-NP) behaviour in domestic on-site wastewater treatment plants and in sewage sludge amended-soils.

Mar 23, 2020

Untreated sludge from small-scale on-site domestic wastewater treatment systems (septic tanks) was spiked with 20, 60 and 100 nm silver nanoparticles (Ag-NPs) to investigate Ag-NP behaviour in these...

Neurological outcomes of congenital Zika syndrome in toddlers and preschoolers: a case series.

Mar 23, 2020

Congenital Zika syndrome causes a spectrum of neurological symptoms with varying effects on function that require different therapeutic strategies. To date, this spectrum of effects and its clinical i...

The characteristics and clinical value of chest CT images of novel coronavirus pneumonia.

Mar 23, 2020

To investigate the characteristics and clinical value of chest computed tomography (CT) images of novel coronavirus pneumonia (NCP).Clinical data and CT images of 80 cases of NCP were collected. The c...

Postoperative Pneumonia after Craniotomy: Incidence, Risk Factor, Prediction with Nomogram.

Mar 23, 2020

Postoperative pneumonia is the third most common complication in surgical patients. However, little is known regarding pneumonia after craniotomy, which is the most commonly performed surgery in the n...

Dexmedetomidine alleviates sleep-restriction-mediated exaggeration of postoperative immunosuppression via splenic TFF2 in aged mice.

Mar 23, 2020

Major abdominal procedures could induce dysfunction in the immune system and lead to postoperative immunosuppression. Sleep dysfunction is associated with impaired immune activity. However, the effect...

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