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Critical Care General

[Improved patient safety through a clinical decision support system in laboratory medicine].

Mar 30, 2020

Laboratory diagnostics are essential for diagnosis, initiation of therapy, and monitoring of patients. Laboratory results that are overlooked or incorrectly interpreted lead to adverse events and enda...

Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study.

Mar 30, 2020

Since December, 2019, an outbreak of coronavirus disease 2019 (COVID-19) has spread globally. Little is known about the epidemiological and clinical features of paediatric patients with COVID-19.We re...

Allograft hemorrhage as a manifestation of carbapenem-resistant Klebsiella pneumonia infection in kidney transplant recipients: Case series.

Mar 30, 2020

Carbapenem-resistant Klebsiella pneumonia (CRKP) infections have been a concerning threat, especially in organ transplant patients with very high mortality. Allograft hemorrhage associated with CRKP i...

Lefamulin: A Novel Semisynthetic Pleuromutilin Antibiotic for Community-Acquired Bacterial Pneumonia.

Mar 30, 2020

Community-acquired bacterial pneumonia (CABP) remains a significant cause of morbidity and mortality worldwide. Antimicrobial resistance, including in pathogens that cause CABP, continues to spread at...

Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia.

Mar 30, 2020

To evaluate the pregnant women infected with coronavirus disease 2019 (COVID-19) and provide help for clinical prevention and treatment.All 5 cases of pregnant women confirmed COVID-19 were collected ...

Aspirin Resistance Affects Medium-Term Recurrent Vascular Events after Cerebrovascular Incidents: A Three-Year Follow-up Study.

Mar 30, 2020

: The aim of this prospective, a three-year follow-up study, was to establish the role of high on-treatment platelet reactivity (HTPR) in predicting the recurrence of vascular events in patients after...

Isolated pulmonary embolism is associated with a high risk of arterial thrombotic disease - Results from the VTEval Study.

Mar 30, 2020

Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of venous thromboembolism (VTE).We hypothesized that the presence of isolated PE may signal a chroni...

Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy.

Mar 30, 2020

The current coronavirus disease 2019 (COVID-19) pneumonia pandemic, caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) virus, is spreading globally at an accelerated rate, with a basic rep...

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.

Mar 30, 2020

To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died.Retrospective case series.Tongji Hospital in Wuhan, China.Among a cohort of 799 patients, 113 wh...

Multiscale Biofluidic and Nanobiotechnology Approaches for Treating Sepsis in Extracorporeal Circuits.

Mar 30, 2020

Infectious diseases and their pandemics periodically attract public interests due to difficulty in treating the patients and the consequent high mortality. Sepsis caused by an imbalanced systemic infl...

Epidemiology, Clinical and Microbiologic Profile and Risk Factors for Inpatient Mortality in Pediatric Severe Sepsis in the United States From 2003 to 2014: A Large Population Analysis.

Mar 30, 2020

To evaluate the national trends in pediatric severe sepsis in the United States from 2003 to 2014.For this study, we included nonoverlapping years of Kids Inpatient database and National Inpatient Sam...

Circulating miRNAs expression as potential biomarkers of mild traumatic brain injury.

Mar 30, 2020

TBI is the main cause of death and disability in individuals aged 1-45 in Western countries. One of the main challenges of TBI at present is the lack of specific diagnostic biomarkers, especially for ...

Beneficial association of angiotensin-converting enzyme inhibitors and statins on the occurrence of possible Alzheimer's disease after traumatic brain injury.

Mar 30, 2020

Pathological analysis of brain tissue from animals and humans with a history of traumatic brain injury (TBI) suggests that TBI could be one of the risk factors facilitating onset of dementia with poss...

Effect of mannitol plus hypertonic saline combination versus hypertonic saline monotherapy on acute kidney injury after traumatic brain injury.

Mar 30, 2020

To compare the effect of mannitol plus hypertonic saline combination (MHS) versus hypertonic saline monotherapy (HS) on renal function in patients with traumatic brain injury (TBI).This was a secondar...

A Critical Review of Behavioral and Emotional Disinhibition.

Mar 30, 2020

The theory of "disinhibition" has been very influential in psychiatry and neurology for over a century. Disinhibition has been used to explain clinical findings in many neurological and psychiatric di...

Posttraumatic epilepsy in intensive care unit-treated pediatric traumatic brain injury patients.

Mar 30, 2020

Posttraumatic epilepsy (PTE) is a well-described complication of traumatic brain injury (TBI). The majority of the available data regarding PTE stem from the adult population. Our aim was to identify ...

Effects of dapagliflozin in DAPA-HF according to background heart failure therapy.

Mar 30, 2020

In the DAPA-HF trial, the SGLT2 inhibitor dapagliflozin reduced the risk of worsening heart failure (HF) and death in patients with HF and reduced ejection fraction. We examined whether this benefit w...

A putative placebo analysis of the effects of sacubitril/valsartan in heart failure across the full range of ejection fraction.

Mar 30, 2020

The PARADIGM-HF and PARAGON-HF trials tested sacubitril/valsartan against active controls given renin-angiotensin system inhibitors (RASi) are ethically mandated in heart failure (HF) with reduced eje...

Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction.

Mar 30, 2020

The effect of vericiguat, a novel oral soluble guanylate cyclase stimulator, in patients with heart failure and reduced ejection fraction who had recently been hospitalized or had received intravenous...

The hidden cost of catheter related blood stream infections in patients on parenteral nutrition.

Mar 30, 2020

Parenteral nutrition (PN) is a valuable and life-saving treatment for patients with intestinal failure. While its use is increasing, it has been demonstrated to be a risk factor for intravenous cathet...

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