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Critical Care General

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis.

Apr 15, 2020

Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thro...

Epidemiological and clinical features of 125 Hospitalized Patients with COVID-19 in Fuyang, Anhui, China.

Apr 15, 2020

To investigate the epidemiological and clinical features of patients with COVID-19 in Anhui province of China.In this descriptive study, we obtained epidemiological, demographic, manifestations, labor...

Cytokine Storm: The Sudden Crash in Patients with COVID-19

Apr 08, 2020

It's jarring every time. The sudden crash in patients with COVID-19 All over the world, seemingly mild cases of COVID-19 rapidly morph into severe cases that involve the lower lungs. This may b...

What cells does the novel coronavirus attack?

Apr 07, 2020

Scientists from the Berlin Institute of Health (BIH), Charité - Universitätsmedizin Berlin and the Thorax Clinic at Heidelberg University Hospital, whose collaboration is taking place under the ...

New guidelines on caring for ICU patients with COVID-19

Apr 07, 2020

International panel does quick turnaround McMaster University Hamilton, ON (April 1, 2020) - An international team including McMaster University researchers has come together to issue guidelines for...

Extracellular vesicles containing the transferrin receptor as nanocarriers of apotransferrin.

Apr 06, 2020

Previous work by our group has shown the pro-differentiating effects of apotransferrin (aTf) on oligodendroglial cells in vivo and in vitro. Further studies showed the remyelinating effect of aTf in a...

WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.

Apr 06, 2020

E3 ubiquitin ligase gene, WWP2, is associated with acute kidney injury (AKI). This research was conducted to explore the role of WWP2 in AKI. AKI cell model was produced in human renal proximal tubula...

Single-port robot assisted radical prostatectomy (SP-RARP): a systematic review and pooled analysis of the preliminary experiences.

Apr 06, 2020

Aimed to balance the maximization of oncological results with the minimization of the surgery related impact on patient's quality of life and cosmetic, in 2018, the da Vinci Single-Port (SP) system wa...

Deficiency of platelet adhesion molecule CD226 causes megakaryocyte development and platelet hyperactivity.

Apr 06, 2020

This study used constitutive CD226 gene knockout (KO) mice as a model to investigate the functions and mechanisms of CD226 in megakaryocyte (MK) maturation and platelet activation. Although CD226 defi...

Dual peptide-dendrimer conjugate inhibits acetylation of transforming growth factor β-induced protein and improves survival in sepsis.

Apr 06, 2020

Sepsis is a potentially fatal complication of infections and there are currently no effective therapeutic options for severe sepsis. In this study, we revealed the secretion mechanism of transforming ...

Therapeutic tactics in the deep forms of rectal abscesses complicated by fournie gangrene.

Apr 06, 2020

The aim: To conduct an analysis of the complex treatment of severe forms of rectal abscesses complicated by NF.Materials and methods: The results of treatment in 471 patients with deep forms of RA was...

3D-quantitative structure-activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase.

Apr 06, 2020

Curcumin derivatives have been shown to inhibit replication of human influenza A viruses (IAVs). However, it is not clear whether curcumin and its derivatives can inhibit neuraminidase (NA) of influen...

Autosomal Dominant Hyper IgE Syndrome from a single center in Chongqing, China (2009-2018).

Apr 06, 2020

Autosomal dominant hyper IgE syndrome (AD-HIES) caused by STAT3 gene mutation is a rare primary immunodeficiency disease. To better understand the disease, we described the clinical characteristics of...

A fatal pediatric case infected with reassortant avian influenza A(H5N6) virus in Eastern China.

Apr 06, 2020

Avian influenza A(H5N6) keeps evolving, causing outbreaks in birds and sporadic infections in human. Here we report a fatal pediatric infection caused by a novel reassortant H5N6 virus. The patient wa...

Relationship between Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease in Persons with HIV.

Apr 06, 2020

Non-alcoholic fatty liver disease (NAFLD) and human immunodeficiency virus (HIV) are independently associated with cardiovascular disease (CVD). However, the factors associated with NAFLD in persons l...

Effect of concomitant antiplatelet agents on clinical outcomes in the edoxaban vs warfarin in subjects undergoing cardioversion of atrial fibrillation (ENSURE-AF) randomized trial.

Apr 06, 2020

In ENSURE-AF (NCT02072434), the oral Factor Xa inhibitor edoxaban showed similar efficacy and safety vs enoxaparin-warfarin in patients undergoing electrical cardioversion of nonvalvular atrial fibril...

Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment.

Apr 06, 2020

Prasugrel was approved at a lower dose in 2014 in Japan than in the West because East Asian patients are considered more susceptible to bleeding than Western patients. However, real-world outcomes wit...

Extracranial-intracranial bypass surgery for occlusive atherosclerotic disease of the anterior cerebral circulation: protocol for a systematic review and meta-analysis.

Apr 06, 2020

Occlusive atherosclerotic disease of the anterior cerebral circulation is one of the most common causes of anterior circulation ischemia and stroke. Treatment options include medical therapies (includ...

A protocol for a systematic review and meta-analysis of the diagnostic accuracy of mid-regional pro-adrenomedullin in predicting invasive bacterial infection in children.

Apr 06, 2020

The early recognition of invasive bacterial infections (IBI) in children can be difficult. Clinically it is often challenging to differentiate between the early stages of an IBI and a benign self-limi...

Real life experience with Ceftobiprole in a tertiary care hospital.

Apr 06, 2020

Ceftobiprole is a new therapeutic option for bacterial pneumonia, with activity against most antimicrobial resistant gram-positive cocci, including methicillin-resistant Staphylococcus aureus. Data on...

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