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Osteoporosis

Greater Fracture Risk Reduction With Denosumab Than Bisphosphonates in Osteoporosis

Jul 10, 2024

Denosumab significantly reduced the relative risk (RR) of fractures more than bisphosphonates in pretreated women with osteoporosis. Denosumab significantly reduced the relative risk (RR) of fr...

Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis.

Oct 23, 2023

Osteoporosis, a systemic bone disease defined by decreased bone mass and deterioration of bone microarchitecture, is becoming a global concern. Nodakenin (NK) is a furanocoumarin-like compound isolate...

SIRT1 Asn346 sugar chain promoting collagen deacetylation protective effect on osteoblasts under stress.

Oct 09, 2023

Silencing type information regulator homolog 1 (SIRT1) is a class of nicotinamide adenine dinucleotide (NAD) dependent deacetylases, which is the convergence point of important physiological processes...

Adjusting Trabecular Bone Score (TBS) for level-specific differences reduces FRAX®-based treatment reclassification in patients with vertebral exclusions: The Manitoba BMD Registry.

Sep 25, 2023

Trabecular bone score (TBS) is a FRAX®-independent risk factor for fracture prediction. TBS values increase from cranial to caudal, with the following mean differences between TBS and individual lumb...

Four-year treatment continuation rates of osteoporosis drugs with different dosing intervals  throughout Japan.

Jul 17, 2023

There are approximately 13 million patients with osteoporosis in Japan; however, only 20% of them receive treatment. This study compared the 4-year continuation rates of osteoporosis drugs at differen...

What is the role of CT-Based Hounsfield Unit assessment in the evaluation of Bone Mineral Density in patients undergoing 1- or 2-level lumbar spinal fusion for degenerative spinal pathologies? - A prospective study.

Jun 05, 2023

Computed tomography-based vertebral attenuation values (CT-based HU) have been shown to correlate with T-scores on DEXA scan; and have been acknowledged as an independent factor for predicting fragili...

Persistence with Denosumab in Male Osteoporosis Patients: A Real-World, Non-Interventional Multicenter Study.

May 08, 2023

Persistence with denosumab in male patients has not been adequately investigated, although poor denosumab persistence is associated with a significant risk of rebound vertebral fractures.We retrospect...

The influence of diet and physical activity on bone density of children aged 5-7 years: The Belfast HAPO family study.

May 01, 2023

Osteoporosis is a global health issue, and modifiable behavioural factors need to be identified in childhood to reduce the risk of osteoporosis in later life. The aim of this study was to investigate ...

MetS Is Risk Factor for Osteoarthritis in Women

Apr 24, 2023

Women with severe metabolic syndrome (MetS) are at risk for greater structural knee osteoarthritis progression. Metabolic syndrome (MetS)—a clustering of abdominal obesity and other metabolic...

Comparison of the biomechanical effects of lumbar disc degeneration on normal patients and osteoporotic patients: A finite element analysis.

Feb 27, 2023

Some older patients who suffered from both conditions (disc degeneration and osteoporosis) have higher surgical risks and longer postoperative recovery times. Understanding the relation between disc d...

An automatic sleep-scoring system in elderly women with osteoporosis fractures using frequency localized finite orthogonal quadrature Fejer Korovkin kernels.

Feb 27, 2023

Healthy sleep signifies a good physical and mental state of the body. However, factors such as inappropriate work schedules, medical complications, and others can make it difficult to get enough sleep...

Asia-pacific consensus on osteoporotic fracture prevention in postmenopausal women with low bone mass or osteoporosis but no fragility fractures.

Feb 13, 2023

Postmenopausal women are at significant risk for osteoporotic fractures due to their rapid bone loss. Half of all postmenopausal women will get an osteoporosis-related fracture over their lifetime, wi...

Association of bisphosphonates with diabetes risk and glycemic control: a meta-analysis.

Dec 05, 2022

Previous evidence suggests that bisphosphonates may improve glycemic control. The present meta-analysis, comprising seven studies with 1,233,844 participants, demonstrated that bisphosphonate use was ...

Association of bisphosphonates with diabetes risk and glycemic control: a meta-analysis.

Dec 05, 2022

Previous evidence suggests that bisphosphonates may improve glycemic control. The present meta-analysis, comprising seven studies with 1,233,844 participants, demonstrated that bisphosphonate use was ...

Glucocorticoid Dosing Examined for Bone Protection in Rheumatic Disease

Aug 31, 2022

Although they are beneficial in reducing inflammation, glucocorticoids have been linked with many well-known adverse effects, and their use often elicits fierce debate. Glucocorticoids (GCs) ha...

Sunscreen Does Not Increase Risk for Osteoporotic Fracture

Nov 29, 2021

“For many years, there have been serious concerns among the medical and lay communities surrounding the use of sunscreen and other sun-protective measures with regard to their potentially detrimenta...

Validating the "Treatment Satisfaction Questionnaire for Medication" in Persian, and Evaluating Treatment Satisfaction Among Patients With Psoriasis.

Nov 22, 2021

Psoriasis is a dermatological condition often associated with systemic comorbidities such as arthritis. Because of the vital role of treatment compliance in improvement in patients' condition and the ...

Cognitive decline is associated with an accelerated rate of bone loss and increased fracture risk in women: a prospective study from the Canadian Multicentre Osteoporosis Study.

Jul 22, 2021

Cognitive decline and osteoporosis often coexist and some evidence suggests a causal link. However, there are no data on the longitudinal relationship between cognitive decline, bone loss and fracture...

Association between arthritis and risk of incident diabetes:a nationwide cohort study and updated meta-analysis.

Jul 22, 2021

To prospectively examine the association between arthritis and type 2 diabetes (T2D) in the Chinese population and confirm this association through a comprehensive meta-analysis of cohort studies.Data...

In vivo relationships between lumbar facet joint and intervertebral disc composition and diurnal deformation.

Jul 22, 2021

Spinal motion is facilitated by a "three joint complex", two facet joints and one intervertebral disc at each spinal level. Both the intervertebral discs and facet joints are subject to natural age-re...

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