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Ophthalmology General

Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells.

Oct 04, 2021

Congenital cataracts are the leading cause of childhood blindness. To date, surgical removal of cataracts is the only established treatment, but surgery is associated with multiple complications, whic...

Effect of retinol dehydrogenase gene transfer in a novel rat model of Stargardt disease.

Oct 04, 2021

Dysfunction of the ATPase-binding Cassette Transporter protein (ABCA4) can lead to early onset macular degeneration, in particular to Stargardt disease. To enable translational research into this form...

Brain Activation Induced by Myopic and Hyperopic Defocus From Spectacles.

Oct 04, 2021

To assess neural changes in perceptual effects induced by myopic defocus and hyperopic defocus stimuli in ametropic and emmetropic subjects using functional magnetic resonance imaging (fMRI). This s...

Comparison between estimated and measured myopia progression in Hong Kong children without myopia control intervention.

Oct 04, 2021

To compare myopia progression estimated by the Brien Holden Vision Institute (BHVI) Myopia Calculator with cycloplegic measures in Hong Kong children wearing single-vision distance spectacles over a 1...

Conjunctival impression cytology and tear film parameters in patients with multiple sclerosis.

Oct 04, 2021

To evaluate conjunctival impression cytology (CIC) findings and tear film parameters in patients with multiple sclerosis (MS) compared with controls.Thirty-three patients with MS (MS group) and 33 age...

Topical tacrolimus progylcosomes nano-vesicles as a potential therapy for experimental dry eye syndrome.

Oct 04, 2021

The present work aimed to evaluate the efficacy of topical tacrolimus (0.01%) loaded propylene glycol (PG) modified nano-vesicles (Proglycosomes Nano-vesicles, PNVs) for the treatment of experimental ...

Correlation between Optical Coherence Tomography Angiography and Multifocal Electroretinogram Findings in Patients with Diabetes Mellitus.

Oct 04, 2021

Diabetic retinopathy is characterized by microvascular, neural and glial cell damage. Optical coherence tomography angiography (OCTA) can detect subclinical microvasculopathy while multifocal electror...

Beta-adrenergic glaucoma eye drops reduce lymphatic clearance from the eye: A sequential photoacoustic imaging study.

Oct 04, 2021

Our study aims to determine whether the beta-adrenergic system is involved in the regulation of lymphatic drainage from the eye. For this purpose, we assessed the effect of 2 topical beta-adrenergic b...

Parkin Prevents Glutamate Excitotoxicity Through Inhibiting NLRP3 Inflammasome in Retinal Ganglion Cells.

Oct 04, 2021

Glutamate excitotoxicity is one of the important pathophysiological culprits in retinal ganglion cells (RGCs) damage after acute optic nerve injury such as traumatic optic neuropathies and glaucoma. I...

Utilization of Remote Diabetic Retinal Screening in a Suburban Healthcare System.

Oct 04, 2021

We conducted a cross-sectional study to assess the utilization of a tele-ophthalmology screening program in a low-risk, suburban population of patients with diabetes.A total of 214 diabetic patients w...

Suppression of Diurnal (9AM-4PM) IOP Fluctuations with Minimally Invasive Glaucoma Surgery: An Analysis of Data from the Prospective, Multicenter, Single-Arm GEMINI Study.

Oct 04, 2021

This study analyzes diurnal IOP data (9AM, 12PM, 4PM) from a prospective 12-month trial of the OMNI Surgical System in open-angle glaucoma (OAG) patients with the aim of evaluating effect of MIGS surg...

THE ECONOMIC BURDEN OF VISION LOSS AND BLINDNESS IN THE UNITED STATES.

Sep 27, 2021

Approximately 8 million Americans self-report vision loss and blindness (VL), potentially resulting in a significant economic burden.Estimate the economic burden of VL in the US and by state.Analysis ...

Cone photoreceptor density in the Copenhagen Child Cohort at age 16-17 years.

Sep 27, 2021

To examine cone density in relation to gestational and morphological parameters in the Copenhagen Child Cohort (CCC2000).The macula was imaged using adaptive optics in 1,296 adolescents aged 16-17 ye...

Evaluation of the Ocular Surface, Conjunctival Impression Cytology and Meibomian Gland Dropout in Patients with Familial Mediterranean Fever.

Sep 27, 2021

Familial Mediterranean fever (FMF) is an idiopathic disease with chronic inflammation. We aimed to determine the changes caused by the chronic inflammatory nature of FMF on the ocular surface, meibomi...

Downregulation of acylglycerol kinase suppresses high glucose-induced endothelial-mesenchymal transition in HRECs through regulating the LPAR1/TGF-β/Notch signaling pathway.

Sep 27, 2021

The endothelial-mesenchymal transition (EndMT) participates in the progression of diabetic retinopathy (DR), but cell-intrinsic factors modulating this process remain elusive. In this study, we explor...

The dynamic optotype (Dyop): a novel visual acuity test for use in children.

Sep 27, 2021

To evaluate the "dynamic optotype" (Dyop), a simple visual acuity test based on a dynamic target that requires minimal knowledge of symbols and letters.A total of 160 consecutive, systemically healthy...

Visual Outcomes in Eyes with Neovascular Glaucoma and Anterior Segment Neovascularization Without Glaucoma.

Sep 27, 2021

To find predictive factors of neovascular glaucoma (NVG) development in anterior segment neovascularization without glaucoma (ASNVWG) and poor visual outcomes in eyes that have already developed NVG.R...

Quality of life in adults with childhood glaucoma: An interview study.

Sep 27, 2021

To explore and report on the quality of life (QoL) issues encountered by adults with childhood glaucoma.Exploratory qualitative study.Forty-seven participants with childhood glaucoma (defined as disea...

Retinal Capillary Basement Membrane

Sep 21, 2021

This study states that the Vascular basement membrane (BM) thickening has been hailed over half a century as the most prominent histological lesion in diabetic microangiopathy, and represents an early...

Compound heterozygous mutations in the LTBP2 gene associated with microspherophakia in a Chinese patient: a case report and literature review.

Sep 20, 2021

Microspherophakia (MSP, OMIM 251,750) is a rare inherited autosomal recessive eye disorder characterized by small spherically shaped lens. Several studies have indicated that the transforming growth...

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