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Ophthalmology General

Emerging therapeutic opportunities for integrin inhibitors.

Sep 20, 2021

Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αL�...

Effect of ethnicity and other sociodemographic factors on attendance at diabetic eye screening: a 12-month retrospective cohort study.

Sep 20, 2021

To examine the association of sociodemographic characteristics with attendance at diabetic eye screening in a large ethnically diverse urban population.Retrospective cohort study.Screening visits in t...

Sight-threatening retinopathy in 9 adolescents with early-onset type 1 diabetes.

Sep 20, 2021

In adults, there has been a decline in the incidence of diabetic retinopathy associated with improvements in diabetes management. Data on incident severe diabetic retinopathy in adolescents are sparse...

Juvenile-onset Open-angle Glaucoma - A Clinical and Genetic Update.

Sep 20, 2021

Juvenile-onset open-angle glaucoma (JOAG) is a subset of primary open-angle glaucoma that is diagnosed before 40 years of age. The disease may be familial or non-familial, with proportions varying amo...

A Genotype-Phenotype Analysis of the Bardet-Biedl Syndrome in Puerto Rico.

Sep 20, 2021

Bardet-Biedl syndrome is a complex heterogeneous ciliopathy caused by genetic mutations. Although establishing genotype-phenotype correlations has been challenging, some regional variations have been ...

Gene therapy: perspectives from young adults with Leber's congenital amaurosis.

Sep 20, 2021

To investigate Leber congenital amaurosis (LCA) patients' expectations, decision-making processes and gene therapy-related concerns.Using a qualitative approach, we explored perceptions of gene therap...

Outcomes of Cataract Surgeries Performed in Makeshift Operating Rooms in Rural Camps, Compared to Hospital-based Surgeries in Nepal.

Sep 13, 2021

This study was undertaken to evaluate the complication rates and visual outcomes of outreach cataract surgeries done in makeshift operating rooms.In this retrospective study, surgical outcomes of cons...

Deep feed forward neural network-based screening system for diabetic retinopathy severity classification using the lion optimization algorithm.

Sep 13, 2021

Diabetic Retinopathy (DR) has become a major cause of blindness in recent years. Diabetic patients should be screened on a regular basis for early detection, which can help them avoid blindness. Furth...

EFFECT OF PHARMACOLOGICAL PUPIL DILATION ON INTRAOCULAR LENS POWER CALCULATION IN PATIENTS INDICATED FOR CATARACT SURGERY.

Sep 13, 2021

To evaluate the influence of pupil dilation on ocular parameters measured by optical biometry and the influence of pupil dilation on intraocular lens (PC IOL) power calculation by using the third-gene...

Magnitude of astigmatism - A comparison between eyes.

Sep 13, 2021

Astigmatism is a highly prevalent refractive error and while studies typically focus to describe the axis symmetry between eyes, little is known about the refractive symmetry. Therefore, this study de...

Impact of residual astigmatism and defocus in eyes with trifocal intraocular lenses.

Sep 13, 2021

To assess the impact on visual function of different residual astigmatic situations combined with 0.50D negative defocus at different distances in patients with trifocal intraocular lenses (IOLs).Clí...

Comparison of 6.0 mm versus 6.5 mm Optical Zone on Visual Outcomes after LASIK.

Sep 13, 2021

Previous studies have demonstrated safety and efficacy using 6.0 and 6.5 mm optical zones in the WaveLight EX500 Excimer Laser System but have not evaluated if differing optical zone sizes influence r...

Effects of warm compress on tear film, blink pattern and Meibomian gland function in dry eyes after corneal refractive surgery.

Sep 13, 2021

To assess the effects of warm compress (WC) on tear film lipid layer, blink pattern and Meibomian gland function in patients with dry eye following femtosecond laser small incision lenticule extractio...

Ocular Immune-Related Adverse Events Associated With Immune Checkpoint Inhibitors in Lung Cancer.

Sep 13, 2021

Immune checkpoint inhibitors (ICIs) are novel immunotherapy-based drugs that have become increasingly popular in the treatment of lung cancer. Researchers have recognized ocular immune-related adverse...

PRE-RETINOPATHY OF TYPE 1 DIABETES IN THE CONTEXT OF FUNCTIONAL, STRUCTURAL AND MICROCIRCULATORY CHANGES IN THE MACULAR AREA.

Sep 13, 2021

The authors assessed the development of intraocular changes in type 1 diabetes (T1DM) from the onset of the disease leading to diabetic retinopathy (DR). The quote: “There must be an intermediat...

Incidence of diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus over 5 years: Contribution of Β-cell function.

Sep 13, 2021

Identifying and modulating risk factors is essential to prevent visual impairment due to diabetic retinopathy (DR). This study examines incident DR with metabolic and hormonal factors in newly-diagnos...

Fundus Photography as the Base of Three-Tier Diabetic Retinopathy Care System to Its Wider Roles: Learning from a Case Experience.

Sep 13, 2021

A case experience of initiating the ocular fundus photography (OFP) service in a diabetes outpatient clinic of a tertiary-care institution is presented. In the community and within the hospitals, the ...

Prevalence of Type II Diabetes Mellitus Among Adult Population in Medical Department of A Tertiary Care Centre.

Sep 13, 2021

Diabetes mellitus is a chronic metabolic disease that is mainly associated with a number of lifestyle behaviors. There is a high discrepancy among urban and rural populations with the prevalence of di...

Age-related changes in the rhesus macaque eye.

Sep 13, 2021

To assess age-related changes in the rhesus macaque eye and evaluate them to corresponding human age-related eye disease.Data from eye exams and imaging tests including intraocular pressure (IOP), len...

The Effect of Achieving Target Intraocular Pressure on Visual Field Worsening.

Sep 13, 2021

To estimate the effect of achieving target intraocular pressure (IOP) values on visual field (VF) worsening in a treated clinical population.Retrospective analysis of longitudinal data.2,852 eyes of 1...

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